Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?

Bellavance, Emily; Lumpkins, Kimberly; Mentha, Gilles; Marques, Hugo P.; Capussotti, Lorenzo; Pulitano, Carlo; Majno, Pietro; Mira, Paulo; Rubbia‐Brandt, Laura; Ferrero, Alessandro; Aldrighetti, Luca; Cunningham, Steven C.; Russolillo, Nadia; Philosophe, Benjamin; Barroso, Eduardo; Pawlik, Timothy M.

doi:10.1007/s11605-008-0652-2

Cited by 81 publications

(54 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2003, Imamura et al [27] were able to report zero mortality in a series of 1056 hepatectomies: However, mortality rates ranging from 2% to 5% (and higher) are still reported by others [23,26,27] . Posthepatectomy liver dysfunction or failure remains an extremely feared complication, still reported in up to 30% of the cases: In spite of major innovations in surgical and anesthesiological techniques and in the postoperative care, mortality remains high [27][28][29][30] . Postoperative liver dysfunction is more frequent in cirrhotic patients who underwent hepatic resection: According to the literature, major risk factors are inadequate preoperative assessment of liver functional reserve, too "aggressive" resection, perioperative hemorrhagic complications and transfusion needs, postoperative infective complications [30][31][32][33][34][35] .…”

Section: The Role Of Igc Clearance Kinetics In the Preoperative Assesmentioning

confidence: 99%

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Gasperi

Mazza

Prosperi

2016

WJH

150

124

View full text Add to dashboard Cite

Indocyanine green (ICG) kinetics (PDR/R15) used to quantitatively assess hepatic function in the perioperative period of major resective surgery and liver transplantation have been the object of an extensive, updated and critical review. New, non invasive bedside monitors (pulse dye densitometry technology) make this opportunity widely available in clinical practice. After having reviewed basic concepts of hepatic clearance, we analysed the most common indications ICG kinetic parameters have nowadays in clinical practice, focusing in particular on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major liver surgery and liver transplantation. As recently pointed out, even if of extreme interest, ICG clearance parameters have still some limitations, to be considered when using these tests. Core tip: Non invasive monitors for indocyanine green (ICG) clearance (PDR and R15) are now available for a rapid assessment of liver function both in the intensive care unit and in major liver surgery. After having reviewed the basic concepts of hepatic clearance, we have analysed the most common indications of ICG kinetic parameters in clinical practice, focusing on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major resective liver surgery and liver transplantation. Since ICG parameters have still some limitations, we will underline the conditions (mainly hyperbilirubinemia and severe peripheral hypoperfusion) able to alter the reliability of these tests.De Gasperi A, Mazza E, Prosperi M. Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? World

show abstract

Section: The Role Of Igc Clearance Kinetics In the Preoperative Assesmentioning

confidence: 99%

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Gasperi

Mazza

Prosperi

2016

WJH

150

124

View full text Add to dashboard Cite

show abstract

“…In addition, liver transplant can be used to treat patients suffering from advanced cirrhosis; perioperative risk would make resection impossible in these patients (4). Liver transplant is therefore the first-line treatment in patients with significantly impaired liver function (8,10).…”

mentioning

confidence: 99%

“…Treatment allocation has not yet been fully clarified (10, e4-e6). There is a need for innovative, effective treatment allocation strategies, particularly in view of the shortage of donor livers (8,10).…”

mentioning

confidence: 99%

Resection or Transplant in Early Hepatocellular Carcinoma

Schoenberg¹,

Bucher

Vater

et al. 2017

Deutsches Ärzteblatt International

View full text Add to dashboard Cite

SUMMARYBackground: Hepatocellular carcinoma (HCC) has an incidence of 5-10 per 100 000 persons per year in the Western world. In 20% of cases, surgical liver resection (LR) or liver transplantation (LT) can be performed. LT results in longer survival, as it involves resection not only of the tumor, but of precancerous tissue as well. The optimal allocation of donor organs depends on the identification of patients for whom LR is adequate treatment. In this meta-analysis, we compare LT and LR for patients with early HCC and wellcompensated cirrhosis.

show abstract

“…Liver resection may present similar short term survival results to orthotopic liver transplantation (OLT), and avoids the long-term adverse eff ects of immunosuppression. However, liver transplantation is associated with longer disease-free survival in well-compensated cirrhotic patients with early stage hepatocellular carcinoma [9].…”

Section: Discussionmentioning

confidence: 99%

The Role of Liver Transplantation in the Treatment of Hepatocellular Carcinoma – a Single Center Experience from Budapest

Piros

Görög

Fehérvári

et al. 2013

Acta Medica Marisiensis

View full text Add to dashboard Cite

Background: Liver transplantation for hepatic tumours is known as a proven treatment opportunity. The outcome has improved over the past decades because of the appropriate recipient selection. Materials and methods:In a single-institution study of 29 consecutive adult patients underwent orthotopic liver transplantation (OLT) between 1 January 2004 and 1 January 2011 in the Semmelweis University, Budapest with the indication of hepatocellular carcinoma (HCC). Results: The 1-year survival was 85.7% and the 3-year survival was 71.7%. Conclusions: Further investigations are needed on the fi eld of histological and biological attributes of the hepatocellular carcinoma. Our aim is to fi nd a better and individualized immunosuppressive protocol, which is also protective against malignant tumours.

show abstract

Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?

Cited by 81 publications

References 60 publications

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Resection or Transplant in Early Hepatocellular Carcinoma

The Role of Liver Transplantation in the Treatment of Hepatocellular Carcinoma – a Single Center Experience from Budapest

Contact Info

Product

Resources

About