Surgical management of endometrial cancer in Slovak Republic

Uharcek, P; Mlyncek, M; Ravinger, J.

doi:10.1016/j.ejso.2005.09.005

Cited by 4 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endometrial cancer is the most common gynecologic malignancy, with an incidence of 25 cases per 100,000 women in Slovakia in 2000 [1]. In 1988 the International Federation of Gynecology and Obstetrics (FIGO) changed the clinical staging of endometrial carcinoma to the surgically based system [2].…”

Section: Introductionmentioning

confidence: 99%

Independent prognostic factors in endometrial cancer: a single institution review

et al. 2011

Self Cite

View full text Add to dashboard Cite

AbstractThe purpose of this study was to conduct a clinical and pathologic review of endometrial cancers diagnosed and surgically treated in our institution to evaluate results of treatment in relation to current international recommendations. We retrospectively evaluated the clinical history, treatment and follow-up of patients with histologically confirmed endometrial cancer treated in Faculty Hospital Nitra, Slovakia from 1990 to 2005. Data were abstracted regarding tumor histology, grade, age, parity, stage, diabetes, use of oral contraceptives, BMI, survival and treatment modalities including surgery, radiation therapy, chemotherapy, hormonal therapy, and combinations thereof. One hundred and thirty nine patients received surgical treatment for endometrial cancer: stage I -101 (72,6%), stage II - 9 (6,5%), stage III - 23 (16,6%) and stage IV - 6 (4,3%). Tumors were well differentiated in 87(62,6%), moderately differentiated in 32 (23%) and poorly differentiated in 20 (14,4%). There were 45 (32,4%) premenopausal patients and 94 (67,6%) postmenopausal. In multivariate statistical analysis we identified FIGO stage, tumor type, tumor grade, nodal status and depth of myometrial invasion as independent prognostic factors for overall survival, and FIGO stage, nodal status, and tumor grade as independent prognostic factors for recurrence-free interval.

show abstract

Section: Introductionmentioning

confidence: 99%

Independent prognostic factors in endometrial cancer: a single institution review

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Surgical treatment of endometrial carcinoma at a Slovakian university hospital

Uharcek

Mlyncek

Lajtman

2010

Intl J Gynecology & Obste

View full text Add to dashboard Cite

invasive carcinoma was detected only in patients with leukoplakia, punctuation, and mosaic findings.Early sexual experience, pluriparity, induced abortion, and high frequency of untreated inflammatory changes are among the many factors that may influence the presence and outcome of cervical changes [3]. Cytologic examinations of the cervix are important for the successful detection of premalignant and malignant changes. Correct evaluation of clinical and morphologic atypia of the vaginal portion of the uterus is the basis of effective therapeutic and preventive measures. Because of the position of the cervix and, thus, the relative ease of evaluation, carcinoma of the cervix can often be detected-even when pre-invasive [4].Most cervical malignancies progress gradually-starting in young women, but manifesting years later; the present study highlights the importance of the early detection of pathologic changes using prophylactic methods such as cytodiagnosis and colposcopy.

show abstract

Methodological considerations in the analysis of the therapeutic significance of lymphadenectomy in endometrial cancer

Todo

Sakuragi

2013

Taiwanese Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

There needs to be clarification on eligibility requirements and procedure standardization with regard to the therapeutic role of lymphadenectomy. If this is not done, consensus on the role of lymphadenectomy will not be reached. Although pelvic lymphadenectomy is not necessary for patients with low-risk Stage I endometrial cancer, it has been suggested that combined pelvic and para-aortic lymphadenectomy is useful for patients with intermediate-/high-risk endometrial cancer. Therefore, the therapeutic role of lymphadenectomy should be continuously evaluated. If such a study is planned, it should not include patients with low risk of nodal metastasis, and one experimental arm of the study should assess combined pelvic and para-aortic lymphadenectomy (fundamentally including the area above the inferior mesenteric artery and the renal vein). It is necessary to establish a pre-operative risk assessment for nodal metastasis and procedural classification of lymphadenectomy. Some pre-operative risk assessments for nodal metastasis have been proposed from Asian countries. The extent of the surgical field is defined as the pelvic area alone, or combined pelvic and para-aortic area. The thoroughness of removal can be split into removal of only suspicious nodes, selective dissection, or systematic dissection. Although randomized controlled trials provide the highest level of clinical evidence, special difficulties are presented in randomized surgical trials. Nonentry of surgeons is a threat to external validity. The role of observational studies, especially prospective cohort studies should be reconsidered when assessing the therapeutic significance of lymphadenectomy.

show abstract

Surgical management of endometrial cancer in Slovak Republic

Cited by 4 publications

References 18 publications

Independent prognostic factors in endometrial cancer: a single institution review

Independent prognostic factors in endometrial cancer: a single institution review

Surgical treatment of endometrial carcinoma at a Slovakian university hospital

Methodological considerations in the analysis of the therapeutic significance of lymphadenectomy in endometrial cancer

Contact Info

Product

Resources

About