Surgical Management of Giant Condyloma Acuminatum (Buschke-Loewenstein Tumor) of the Perianal Region

Paraskevas, Kosmas I.; KYRIAKOS, ELEFTHERIOS; Poulios, Efthimios; Stathopoulos, Vassilios; Tzovaras, Alexandros; Briana, Despina D.

doi:10.1111/j.1524-4725.2007.33125.x

Cited by 22 publications

(25 citation statements)

References 39 publications

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“…[1][2][3][4][7][8][9] The extent of surgical excision is determined by the size of the lesion and the degree of penetration to adjacent structures. 8 Penectomy may be required in extensive penile involvement, with abdominoperineal resection and reconstruction of a new penis with free flap phalloplasty. 5,6 More recently glansectomy has been described as a tissue-sparing alternative to penectomy.…”

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confidence: 99%

“…Nonsurgical treatments are claimed to increase recurrence rates due to insufficient tumour destruction and are usually used to shrink the tumour before surgery. 1,5,7,8 Topical podophyllin 25-30% or 5-fluororacil (5-FU) are futile in eradicating GCA. 1,2,4,7,8 Although successful preliminary reports of HPV vaccination have brought optimism for the future, immunotherapy still remains an investigational therapeutic tool.…”

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confidence: 99%

“…1,5,7,8 Topical podophyllin 25-30% or 5-fluororacil (5-FU) are futile in eradicating GCA. 1,2,4,7,8 Although successful preliminary reports of HPV vaccination have brought optimism for the future, immunotherapy still remains an investigational therapeutic tool. 1,10 Intralesional or systemic interferon-a2b may be effective in GCA because of its immunomodulating, antiproliferative and antiviral properties.…”

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confidence: 99%

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Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Erkek

Başar²,

Bozdoğan³

et al. 2009

Clinical and Experimental Dermatology

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Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.

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Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Erkek

Başar²,

Bozdoğan³

et al. 2009

Clinical and Experimental Dermatology

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“…El condiloma acuminado gigante o tumor de Buschke-Löwenstein corresponde a una patología benigna, secundaria a la infección por virus papiloma humano, con una incidencia de 0,1% en población general y que puede tener transformación maligna 1 . Fue descrito por primera vez en el año 1896 por Buschke, y por Löwenstein en 1925 como un tumor del pene, sin embargo, puede presentarse en múltiples localizaciones como el área genital, región perineal y otras regiones como la vejiga 2,3 .…”

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Reconstrucción Perineal Inmediata en Extensa Resección Abdominoperineal Rectal

et al. 2015

Rev Chil Cir

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immediate perineal reconstruction after vast rectal abdominoperineal resection background: Buschke-Lowenstein tumor is a benign skin lesion secondary to human papilloma virus infection. It usually appears as an exophytic anogenital mass and may progress to a squamous cell carcinoma. It can be treated with chemo, radio or immunotherapy and occasionally it requires radical surgery. case report: We report a 53 years old male with a perianal lesion lasting 15 years that was treated with chemoradiotherapy that relapsed with malignant transformation. Since the pathological study showed a squamous cell carcinoma, a rectal abdominoperineal resection was planned. The defect that left the surgical procedure was covered with musculocutaneous flaps from gracilis muscle of the thigh.

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“…It is the most common sexually transmitted infection of anorectal region [1]. Incidence rate in general population is 0.1% [2]. 2-3 million new cases are added every year to condyloma acuminatum especially with growing numbers in homosexual male population [3].…”

Section: Introductionmentioning

confidence: 99%

Perianal Giant Condyloma Acuminatum—Buschke-Löwenstein Tumor: A Case Report

Taş

Arik

Özkul

et al. 2012

Case Reports in Surgery

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Condyloma acuminatum caused by Human Papillomavirus is the most commonly occurring sexually transmitted infection in the anogenital region. Buschke-Löwenstein tumor (BLT) known also as giant condyloma acuminatum is a rare disease. The disease, for which the most important treatment method is the surgical excision, differs from normal condyloma acuminatum cases with its high degree of malignancy. The purpose of this paper is to present the case that reached huge dimensions in the perianal region and that was treated with wide resection in the literature.

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Surgical Management of Giant Condyloma Acuminatum (Buschke-Loewenstein Tumor) of the Perianal Region

Cited by 22 publications

References 39 publications

Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Reconstrucción Perineal Inmediata en Extensa Resección Abdominoperineal Rectal

Perianal Giant Condyloma Acuminatum—Buschke-Löwenstein Tumor: A Case Report

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