2012
DOI: 10.1016/j.jamcollsurg.2012.03.020
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Surgical Management of Inoperable Lymphedema: The Re-emergence of Abandoned Techniques

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Cited by 24 publications
(30 citation statements)
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References 34 publications
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“…72 It is caused by an imbalance in the f low of lymphatic f luid into and out of the interstitium, and it primarily affects the dermal and subcutaneous tissues. 73 Chronically accumulated lymphatic f luid causes cutaneous dermal thickening, hypercellularity, and progressive fibrosis. Secondary to restricted lipid transport from limited lymph f low, lipids accumulate in adipocytes and macrophages, resulting in increased adipose tissue.…”
Section: Lymphedemamentioning
confidence: 99%
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“…72 It is caused by an imbalance in the f low of lymphatic f luid into and out of the interstitium, and it primarily affects the dermal and subcutaneous tissues. 73 Chronically accumulated lymphatic f luid causes cutaneous dermal thickening, hypercellularity, and progressive fibrosis. Secondary to restricted lipid transport from limited lymph f low, lipids accumulate in adipocytes and macrophages, resulting in increased adipose tissue.…”
Section: Lymphedemamentioning
confidence: 99%
“…Unfortunately, there is no universally accepted standardized treatment. 73,77 Conservative, nonsurgical, management of lymphedema is often the first-line treatment. However, it cannot address the changes that arise in the setting of severe, endstage disease.…”
Section: Lymphedemamentioning
confidence: 99%
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“…Because debulking destroys any functioning lymphatic vessels, this technique is not appropriate for early-stage lymphedema ( Doscher et al, 2012 ). This technique involves removing the skin and subcutaneous tissue down to the fascia, followed by primary closure or skin grafting.…”
Section: Surgical Managementmentioning
confidence: 99%
“…Partly due to the unpredictable outcomes of the radical surgical procedures performed in the past and partly due to the unfamiliarity of the surgeons with these techniques, operations that are extremely powerful in decreasing the size of the limb have been sentenced to oblivion. Patients crippled with this devastating malady are deemed incurable not only by medical practitioners but also as inoperable by surgeons . We have devised a comprehensive multimodal surgical treatment (CMST) of end‐stage lymphedema that combines improved versions of previously defined procedures to offer a comprehensive management: (1) Charles’ and Homan’s procedures to remove the damaged skin and fibrotic subcutaneous tissue, (2) VLNT to reestablish lymphatic function and thereby immunocompetence in the distal extremity, and (3) individualized toe management to eliminate a major source of infection.…”
Section: Introductionmentioning
confidence: 99%