Surgical management of malignant cerebral edema secondary to immune reconstitution inflammatory syndrome from natalizumab-associated progressive multifocal encephalopathy

No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML

“…In addition, inflammation activates effector macrophages and microglia, further amplifying the inflammatory reaction and prompting blood-brain barrier damage, brain injury, and cerebral edema. 9 This immunopathologic cascade is responsible for the devastating effects that lead to great clinical disability and possibly death.…”