Surgical Management of Melanoma in Situ on Chronically Sun-Damaged Skin

Clark, Graham S.; Pappas-Politis, Effie; Cherpelis, Basil S.; Messina, Jane L.; Möller, Mecker G.; Cruse, C. Wayne; Glass, L. Frank

doi:10.1177/107327480801500304

Cited by 47 publications

(34 citation statements)

References 42 publications

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“…In contrast, despite the above considerations, CMIS is linked to some health concerns and unsolved debates regarding its clinicopathologic diagnosis [19 -24], therapeutic/follow-up management [20,[25][26][27][28][29], and prognostic relevance [24, 30 -32].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Melanoma In Situ: Translational Evidence from a Large Population-Based Study

Mocellin

Nitti

2011

The Oncologist

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Background. Cutaneous melanoma in situ (CMIS) is a nosologic entity surrounded by health concerns and unsolved debates. We aimed to shed some light on CMIS by means of a large population-based study. Methods. Patients with histologic diagnosis of CMIS were identified from the Surveillance Epidemiology End Results (SEER) database.Results. The records of 93,863 cases of CMIS were available for analysis. CMIS incidence has been steadily increasing over the past 3 decades at a rate higher than any other in situ or invasive tumor, including invasive skin melanoma (annual percentage change [APC]: 9.5% versus 3.6%, respectively). Despite its noninvasive nature, CMIS is treated with excision margins wider than 1 cm in more than one third of cases. CMIS is associated with an increased risk of invasive melanoma (standardized incidence ratio [SIR]: 8.08; 95% confi-

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Section: Introductionmentioning

confidence: 99%

Cutaneous Melanoma In Situ: Translational Evidence from a Large Population-Based Study

Mocellin

Nitti

2011

The Oncologist

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“…Additional stages of excision are performed as necessary with processing in the same manner as above. 33 When all margins are free of tumor, the defect is repaired. Shriner has provided a detailed description of Mohs surgery.…”

Section: Mohs Surgery and MCCmentioning

confidence: 99%

The Surgical Management of Primary and Metastatic Merkel Cell Carcinoma

Gonzalez

Padhya

Cherpelis

et al. 2010

Current Problems in Cancer

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“…It causes the majority (75%) of deaths related to skin cancer. The treatment of choice if it is discovered early is surgical removal of the tumor 4. Surgical treatment is successful while it is still small and thin, and if it is completely removed, then the chance of cure is high.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Suicide Gene Therapy with Adenosine Deaminase 5-Fluorocytosine Silmutaneously in in Vitro Cultures of Melanoma and Retinal Cell Lines

Sakkas¹,

Domvri²,

Hohenforst-Schmidt³

et al. 2014

J. Cancer

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Local treatment as a treatment modality is gaining increased general acceptance over time. Novel drugs and methodologies of local administration are being investigated in an effort to achieve disease local control. Suicide gene therapy is a method that has been investigated as a local treatment with simultaneously distant disease control. In our current experiment we purchased HTB-70 (melanoma cell line, derived from metastatic axillary node) and CRL-2302 (human retinal epithelium) were from ATCC LGC Standards and Ancotil®, 2.5 g/250 ml (1 g/00ml) (5-Flucytosine) MEDA; Pharmaceuticals Ltd. UK. Adenosine Cytosine Deaminase (Ad.CD) was also used in order to convert the pro-drug 5-Flucytosine to the active 5-Fluoracil. Three different concentrations of 5-Flucytosine (5-FC) were administered (0.2ml, 0.8ml and 1.2ml). At indicated time-points (4h, 8h and 24h) cell viability and apoptosis were measured. Our concept was to investigate whether suicide gene therapy with Ad. CD-5-FC could be used with safety and efficiency as a future local treatment for melanoma located in the eye cavity. Indeed, our results indicated that in every 5-FC administration had mild cytotoxicity for the retinal cells, while increased apoptosis was observed for the melanoma cell line.

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Surgical Management of Melanoma in Situ on Chronically Sun-Damaged Skin

Cited by 47 publications

References 42 publications

Cutaneous Melanoma In Situ: Translational Evidence from a Large Population-Based Study

Cutaneous Melanoma In Situ: Translational Evidence from a Large Population-Based Study

The Surgical Management of Primary and Metastatic Merkel Cell Carcinoma

Safety and Efficacy of Suicide Gene Therapy with Adenosine Deaminase 5-Fluorocytosine Silmutaneously in in Vitro Cultures of Melanoma and Retinal Cell Lines

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