Surgical Management of Mucinous Cystic Neoplastic Lesions of the Pancreas

Sahora, Klaus; Castillo, Carlos Fernández‐del

doi:10.1002/9781118307816.ch34

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Following the affirmation of linearity for the designated target products, namely, ( 2a ), ( 3a ), or ( 4a ), we proceeded to compute the absolute error. In all the evaluated scenarios, the derived errors aligned satisfactorily with established guidelines and methods specifically tailored for validating ESI-MS experiments. , The calculated errors can be found in Tables S5–S7 in the SI.…”

Section: Resultssupporting

confidence: 55%

“…In all the evaluated scenarios, the derived errors aligned satisfactorily with established guidelines and methods specifically tailored for validating ESI-MS experiments. 42,46 The calculated errors can be found in Tables S5−S7 in the SI.…”

Section: Esi-ms and Nmr Comparative Analysis For Investigating The Ev...mentioning

confidence: 99%

“…There are a variety of ionization sources available for solving different quantification tasks. Quantitative MS often employs deuterated internal standards, − leveraging the MS signal intensities of the substrate and standard for quantitation. Ideal internal standards should share similar ionization response factors with the subject substrate and not have overlapping isotopic distributions. , Interestingly, while electrospray ionization mass spectrometry (ESI-MS) has been applied for the qualitative observation of compound formation in real catalytic systems, ,, quantitative analysis has been reported only for model conditions at 5 mol % Pd/NHC loading .…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Determination of Active Species Transforming the R-NHC Coupling Process under Catalytic Conditions

Patil,

Burykina,

Eremin

et al. 2024

Inorg. Chem.

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Palladium complexes with N-heterocyclic carbenes (Pd/NHC) serve as prominent precatalysts in numerous Pd-catalyzed organic reactions. While the evolution of Pd/NHC complexes, which involves the cleavage of the Pd− C(NHC) bond via reductive elimination and dissociation, is acknowledged to influence the catalysis mechanism and the performance of the catalytic systems, conventional analytic techniques [such as NMR, IR, UV−vis, gas chromatography−mass spectrometry (GC−MS), and high-performance liquid chromatography (HPLC)] frequently fail to quantitatively monitor the transformations of Pd/NHC complexes at catalyst concentrations typical of real-world conditions (below approximately 1 mol %). In this study, for the first time, we show the viability of using electrospray ionization mass spectrometry (ESI-MS). This approach was combined with the use of selectively deuterated H-NHC, Ph-NHC, and O-NHC coupling products as internal standards, allowing for an in-depth quantitative analysis of the evolution of Pd/NHC catalysts within actual catalytic systems. The reliability of this approach was affirmed by aligning the ESI-MS results with the NMR spectroscopy data obtained at greater Pd/NHC precatalyst concentrations (2−5 mol %) in the Mizoroki−Heck, Sonogashira, and alkyne transfer hydrogenation reactions. The efficacy of the ESI-MS methodology was further demonstrated through its application in the Mizoroki−Heck reaction at Pd/NHC loadings of 5, 0.5, 0.05, and 0.005 mol %. In this work, for the first time, we present a methodology for the quantitative characterization of pivotal catalyst transformation processes commonly observed in M/NHC systems.

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Section: Resultssupporting

confidence: 55%

Section: Esi-ms and Nmr Comparative Analysis For Investigating The Ev...mentioning

confidence: 99%