Surgical management of osteoarthritis

Proffen, Benedikt L.; Vavken, Patrick; Dorotka, Ronald

doi:10.1007/s10354-013-0199-z

Cited by 7 publications

(6 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One such intervention is arthroplasty, a procedure designed to partially or entirely replace, remodel, or realign the compromised joint. This approach, and in particular, total joint arthroplasty, is highly effective and safe for treating knee and hip OA and is also being used for spine, shoulder, ankle, and elbow joints [239]. Surgery is less commonly employed for conditions affecting the hands, where the side effects outweigh the benefits.…”

Section: Surgical Approachesmentioning

confidence: 99%

“…Osteotomy can alleviate pain and postpone the need for other surgical interventions, offering short-term relief. It may be considered in cases of early joint malalignment without significant cartilage damage or limited joint destruction [239]. It may be considered in cases of early joint malalignment without significant cartilage damage or limited joint destruction [239].…”

Section: Surgical Approachesmentioning

confidence: 99%

See 1 more Smart Citation

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

Coppola,

Greco,

Munir

et al. 2024

CIMB

View full text Add to dashboard Cite

Osteoarthritis (OA) stands as a prevalent and progressively debilitating clinical condition globally, impacting joint structures and leading to their gradual deterioration through inflammatory mechanisms. While both non-modifiable and modifiable factors contribute to its onset, numerous aspects of OA pathophysiology remain elusive despite considerable research strides. Presently, diagnosis heavily relies on clinician expertise and meticulous differential diagnosis to exclude other joint-affecting conditions. Therapeutic approaches for OA predominantly focus on patient education for self-management alongside tailored exercise regimens, often complemented by various pharmacological interventions primarily targeting pain alleviation. However, pharmacological treatments typically exhibit short-term efficacy and local and/or systemic side effects, with prosthetic surgery being the ultimate resolution in severe cases. Thus, exploring the potential integration or substitution of conventional drug therapies with natural compounds and extracts emerges as a promising frontier in enhancing OA management. These alternatives offer improved safety profiles and possess the potential to target specific dysregulated pathways implicated in OA pathogenesis, thereby presenting a holistic approach to address the condition’s complexities.

show abstract

Section: Surgical Approachesmentioning

confidence: 99%

Section: Surgical Approachesmentioning

confidence: 99%

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

Coppola,

Greco,

Munir

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…Replacing the weight-bearing surfaces of the knee joint to relieve pain and disability is recommended, if conservative therapies are unsuccessful. Revision TKA is frequently required and can be problematic [Bhandari et al 2012;Proffen et al 2013] COX2, cyclooxygenase-2; NSAIDs, nonsteroidal anti-inflammatory drugs; OA, osteoarthritis. patients within 10 years, the procedure is more indicated for young and active patients with a life expectancy exceeding that of a knee prosthesis [Virolainen and Aro, 2004;Bhandari et al 2012;Spahn et al 2013].…”

Section: Osteotomymentioning

confidence: 99%

“…This procedure replaces the weight-bearing surfaces of the knee joint to relieve pain and disability. While good long-term outcomes from surgery can usually be expected, revision surgery for TKA is often required, substantially increasing the risk for subsequent complications, since much of the original joint structure is sacrificed during the first round of surgery [Bhandari et al 2012; Proffen et al 2013]. Arthroscopy is a prevalent orthopedic surgical procedure suggested for cases where symptoms derive from mechanically unstable joint tissues [Hunter and Felson, 2006; WHO, 2013], and unicompartmental knee arthroplasty and osteotomy provide alternatives for patients with OA confined to one joint compartment [Bhandari et al 2012].…”

Section: Hierarchy Of Treatment Options For Knee Oamentioning

confidence: 99%

How does surgery compare with advanced intra-articular therapies in knee osteoarthritis: current thoughts

Wehling

Moser

Maixner

2016

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

Abstract:The objectives of osteoarthritis (OA) management are to reduce pain and inflammation, slow cartilage degradation, improve function and reduce disability. Current strategies for managing knee OA include nonpharmacological interventions, oral pharmacological treatments, localized intra-articular injections, and surgery. It has become evident that the inflammatory response is a key contributor to the development and progression of knee OA. Signaling pathways involving growth factors and cytokines are being investigated for the development of new therapies that target the underlying biological processes causing the disease. This concept of 'molecular orthopedics' enables more patient-centered diagnostic and treatment strategies. In contrast to other conservative therapies, which ultimately only address OA symptoms, intra-articular injections, in particular autologous conditioned serum (ACS), provide benefits that have the potential to outweigh those of established pharmacological treatments and surgery. Surgery has historically been considered the final solution for treatment of knee OA, both by treating physicians and by patients; however, there are increasing concerns regarding the lack of randomized clinical trials providing evidence to support this opinion. Intra-articular injection of ACS has demonstrated efficacy as a treatment for knee OA in a number of studies, with a very low rate of adverse events and side effects, compared with surgery. Treatment with ACS utilizes the release of anti-inflammatory cytokines and regenerative growth factors to support the natural healing processes in the knee, and has the potential to provide a valuable alternative to surgical intervention.

show abstract

“…The conservative interventions of OA mainly include injection of intra-articular hyaluronic acid, and oral non-steroidal anti-inflammatory drugs; however, these treatments could only alleviate chronic pain [7–9]. Although surgical arthroplasty is applied to treat severe degenerative joint diseases, it may cause several severe postoperative complications [10,11]. Therefore, it is essential to explore some new effective therapeutic measures for articular cartilage damage.…”

Section: Introductionmentioning

confidence: 99%

miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6

2019

Bioscience Reports

View full text Add to dashboard Cite

Various of microRNAs (miRNAs) have been reported to regulate the chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), however, whether miR-134 plays a role in this biological process remains undetermined. In this present study, we firstly evaluated the chondrogenic differentiation of BMSCs by Alcian blue staining, and examined the miR-134 expression by qRT-PCR during this process. And miR-134 inhibitor was used to investigate the functions of miR-134 in chondrogenic differentiation of BMSCs by Alcian blue staining, qRT-PCR and western blot. Subsequently, the correlation between miR-134 and SMAD6 was assessed via bioinformatics analysis and dual luciferase reporter assay. Finally, the roles of SMAD6 in chondrogenic differentiation of BMSCs was also determined through Alcian blue staining, qRT-PCR and western blot. As results showed that miR-134 expression was significantly downregulated during chondrogenic differentiation, and inhibition of miR-134 obviously promoted chondrogenic differentiation. Dual luciferase reporter assay indicated that miR-134 could directly targeted the 3'-UTR of SMAD6, inhibited miR-134 expression in BMSCs could upregulate SMAD6 expression. Moreover, we found that overexpression of SMAD6 significantly promoted chondrogenic differentiation, and this SMAD6 induced promotion of chondrogenic differentiation could be reversed by miR-134 mimics. In conclusion, our findings suggested that miR-134 may act as a negative regulator during chondrogenic differentiation of BMSCs by interacting with SMAD6.

show abstract

Surgical management of osteoarthritis

Cited by 7 publications

References 70 publications

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts

How does surgery compare with advanced intra-articular therapies in knee osteoarthritis: current thoughts

miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6

Contact Info

Product

Resources

About