Surgical Management of Ovarian Cancer

Abstract

Advanced ovarian cancer remains a disease with a poor prognosis. Surgical therapy remains the cornerstone of treatment with essential contribution from chemotherapy. The combination therapy continues to offer the best treatment strategy. Complete cytoreductive surgery is still the most important prognostic marker. The role of primary debulking surgery in advanced ovarian cancer remains under investigation through high quality rigorous clinical trials. The current evidence regarding primary versus interval debulking surgery has drawn much criticism regarding patient recruitment and quality of surgery, both of which are key pillars in achieving complete cytoreduction. It is expected that greater centralisation and development of 'ovarian cancer surgery teams' will further enhance clinical outcomes.

A Recipe for Successful Metastasis: Transition and Migratory Modes of Ovarian Cancer Cells

“…The main treatment in OC is surgery. In most cases, it involves removing the ovaries, fallopian tubes, uterus, omentum, appendix (in the case of a mucinous type of OC), and all the metastatic foci that are technically able to be extracted [138]. If the surgical removal of the tumor is not possible, neoadjuvant chemotherapy should be administered.…”

“…If the surgical removal of the tumor is not possible, neoadjuvant chemotherapy should be administered. After three to six courses of neoadjuvant chemotherapy, surgery should again be taken into consideration [138]. All patients diagnosed in a clinical stage higher than IA-G1 (highly differentiated cancer), according to FIGO, are obligatorily subjected to postoperative chemotherapy.…”