Surgical Management of Periocular Cancers: High- and Low-Risk Features Drive Treatment

Allen, Richard C.

doi:10.1007/s11912-017-0618-1

Cited by 13 publications

(11 citation statements)

References 74 publications

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“…Full-thickness eyelid tumor resection with posterior lamellar is the golden standard and superior to non posterior lamellar resection [25,26]. Mohs surgery has been recommended as treatment of sebaceous carcinoma with excellent results with 11% recurrence rate for primary tumours [27][28][29][30][31]. However, Mohs surgery is resourcesand time-demanding and not available everywhere.…”

Section: Treatmentmentioning

confidence: 99%

“…Pfeiffer et al [50] have reported SLNB to identify nodal micrometastasis in 20% of ocular adnexal melanoma cases. However, in tumors, such as sebaceous carcinoma, that spread via the lymphatic system before spreading systematically SLNB is justifiable in tumors with a significant metastatic risk [30].…”

Section: Fig 4 Scanning For Regional Lymph Nodes or Metastatic Diseamentioning

confidence: 99%

“…Postoperative radiation after exenteration in T3 tumors (AJCC 7-th edition) is reported to significantly reduce the risk of recurrent disease [52]. Radiation has also been recommended for recurrent disease after exenteration [13] and postoperatively if insufficient margins [46] or perineural spread [8,30,46] is detected. Xu et al [49] recommend radiation therapy for T3 or higher (AJCC 7-th edition), pagetoid spread, nodal metastasis or palliative care.…”

Section: Fig 4 Scanning For Regional Lymph Nodes or Metastatic Diseamentioning

confidence: 99%

“…[ 6-8, 12, 13, 20, 27-37] Sentinel lymph node biopsies SLNB could be considered for tumours larger than 10 mm. [15,18,30,[44][45][46][47][48][49][50] PET/CT PET/CT could be considered in the initial staging.…”

Section: Follow-upmentioning

confidence: 99%

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Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

et al. 2020

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Background: The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma. Methods: The treatment practices data was collected by a questionnaire with 37 questions to the Nordic oculoplastic surgeons and analyzed. A PubMed MEDLINE database search was done to gather data on the published treatment practices and recommendations. A working group that consisted of in minimum one senior consultant from each leading Nordic University Eye Hospital was assigned. A structured interactive method was used to establish the consensus. Results: Twenty-four doctors responded to the questionnaire. 23/24 (96%) of the respondents took a biopsy before surgery. Regional lymph node scanning was routinely done by 14/23 (61%) and a systemic screening of a metastatic disease by 13/23 (57%). 6/22 (27%) never took conjunctival mapping biopsies and 12/23 (52%) never screened for Muir-Torre. Respondents used Mohs surgery, frozen section or multi-stage excision with delayed closure, and 5-6 mm was the mostly preferred margin. Sentinel lymph node biopsy was a possible option for 9/22 (41%) and cryotherapy and Mitomycin C for 6/22 (27%) respondents. 50% of respondents considered radiation as a treatment option. 15/16 (94%) respondents always followed-up their patients, most for 5 years. Two thirds scanned regional lymph nodes during the follow-up. Consensus was reached for 18 statements representing three domains: preoperative work-up, treatment and follow-up. Conclusion: Treatment practices differ in between the five Nordic countries which have similar public health care systems. In the article the authors present a Nordic consensus for the treatment of eyelid sebaceous carcinoma.

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Section: Treatmentmentioning

confidence: 99%

Section: Fig 4 Scanning For Regional Lymph Nodes or Metastatic Diseamentioning

confidence: 99%

Section: Fig 4 Scanning For Regional Lymph Nodes or Metastatic Diseamentioning

confidence: 99%

Section: Follow-upmentioning

confidence: 99%

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Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

et al. 2020

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“…5 d), welches chirurgisch mittels eines großen Sicherheitsabstands sowie ggf. auch mittels adjuvanter Bestrahlung angegangen werden sollte [14]. Trotzdem ist der Verlauf bei neurotropem Wachstum oft durch Rezidive gekennzeichnet.…”

Section: Plattenepithelkarzinomunclassified

Lidtumoren: Klinische Aspekte der Ophthalmopathologie

Herwig‐Carl

Löffler

2018

Klin Monatsbl Augenheilkd

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Lid tumors can develop from different structures of the eyelid and, therefore, show a wide spectrum of clinical findings. If a malignant process is suspected or the clinical diagnosis cannot be unequivocally determined, a biopsy (incisional vs. excisional) is necessary followed by histologic evaluation. Furthermore, inadequately treated benign lesions, such as an incomplete excised nevus or a molluscum contagiosum, can lead to serious problems.

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Lymph Node Evolution in Eyelid and Orbit Squamous Cell Carcinomas

Chebib,

Rougier,

Dubray‐Vautrin

et al. 2024

The Laryngoscope

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ObjectivesTo describe a large cohort of eyelid and periorbital SCCs, to compare the location of the tumor and of the pathological lymph nodes, and to analyze the risk factors for lymph node involvement among tumor characteristics.MethodsAll patients managed inside our institution for an eyelid and periorbital SCCs were included. Tumor characteristics, imaging setup, excision margins, lymph node evolution features, local, regional, and distant recurrences rates, and global survival were reported. The risk for lymph node involvement and location of pathological lymph nodes were analyzed through univariate and multivariate analyses.ResultsBetween January 2012 and August 2022, 115 patients were included, and 18 presented a lymph node evolution (15.7%), involving the parotid gland in 16 cases (88.9%), the submental and submandibular areas in seven cases (38%), and the jugular and carotid areas in four cases (22%). Tumor size above 20 mm, infiltration of the external canthus and periorbital structures, the presence of perineural invasion or vascular embolism, the depth of infiltration, and the presence of a local recurrence were significantly associated with the risk of lymph node evolution.ConclusionPeriorbital and eyelid SCCs present a true potential for lymph node evolution especially through the parotid gland. Extension setup including the parotid gland and neck should be mandatory, and lymph node dissection should be associated in case of parotidectomy for lymph node involvement.Level of EvidenceIV Laryngoscope, 2024

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Surgical Management of Periocular Cancers: High- and Low-Risk Features Drive Treatment

Cited by 13 publications

References 74 publications

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

Lidtumoren: Klinische Aspekte der Ophthalmopathologie

Lymph Node Evolution in Eyelid and Orbit Squamous Cell Carcinomas

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