Surgical Management of Pulmonary Disease Due to Mycobacterium avium-intracellulare

The clinical efficacy and safety of a fluoroquinolone-containing regimen for pulmonary MAC disease

“…RFP ? EB, shows a good clinical response, relapses are common [7,8]. The major limitations of effective therapy are the absence of antimicrobial agents with low toxicity and good in vivo activity against the organism [2].…”

“…Several studies have indicated that the clarithromycin (CAM)-containing regimen demonstrates response rates of 59-92% [4][5][6]. However, frequent relapses have also been observed after the completion of medical therapy [7,8]. Therefore, the treatment protocol for pulmonary MAC remains insufficient.…”

Surgical Approach to Pulmonary Nontuberculous Mycobacterial Infections

“…[4][5][6][7][8][9] In general, these operations, despite their complexity, may be performed with low morbidity and mortality. Some of the reported differences may be attributed to the varying patient populations and operations described.…”

Treatment of pulmonary disease caused by opportunist mycobacteria.

“…In one series 33% of patients ultimately relapsed after having surgery45; in another series complications, including bronchopleural fistula, developed in 24% of patients and there was a 7% postoperative mortality. 7 Medical treatment is the only therapeutic option available for many patients. Pessimistic reports on the results of chemotherapy have often failed to indicate the duration of treatment given before it was concluded to be unsuccessful.…”