Surgical management of pulmonary inflammatory pseudotumors: A single center experience

Abstract

BackgroundThe pulmonary inflammatory pseudotumor (PIP) is a rare disease. It is still debated whether it represents an inflammatory lesion characterized by uncontrolled cell growth or a true neoplasm. PIP is characterized by a cellular polymorphism.MethodsWe retrospectively analyzed 8 patients with PIP treated by surgery between 2001 and 2009. Preoperative thoracic computed tomography (CT) scan was performed in all cases. All patients underwent preoperative bronchoscopy with washing and brushing and/or transbronchial biopsy and preoperative cytology examinationResultsThere were 5 men and 3 women, aged between 38 and 69 years (mean of 58 years). 3 patients (37%) were asymptomatic. The others had symptoms characterized by chest pain, shortness of breath and persistent cough or hemoptysis. 5 patients had neutrophilic leucocytosis. CT scan demonstrated solitary nodules (maximum diameter <3 cm) in 5 patients (62%) and lung masses (maximum diameter >3 cm) in 3 patients (37%). In 2 patients there were signs of pleural infiltration. Distant lesions were excluded in all cases. A preoperative histology examination failed to reach a definitive diagnosis in all patients. At surgery, we performed two lobectomies, one segmentectomy and five wedge resections, these being performed with videothoracoscopy (VATS), except for one patient where open surgery was used. Complete tumor resection was obtained in all patients. According to the Matsubara classification, there were 2 cases of organizing pneumonia, 5 cases of fibrous histiocytoma and one case of lymphoplasmacytoma. All patients were discharged alive from hospital between 4 and 7 days after surgery. At follow-up CT scan performed annually (range 11 to 112 months) (mean 58 months), there were no residual lesions, neither local nor distant recurrences.ConclusionsPIP is a rare disease. Many synonyms have been used for this disease, usually in relation to the most represented cell type. The true incidence is unclear. Preoperative diagnosis is difficult to reach, despite performing a bronchoscopy or a transparietal needle aspiration. Different classifications have been proposed for PIP. Either medical, radiation or surgical therapy has been used for PIP. Whenever possible, surgery should be considered the standard treatment. Complete surgical resection is advocated to prevent recurrence.

Tracheal localization of inflammatory myofibroblastic tumor in adults: A case report

“…IMT of respiratory organs is the most frequently related to an ambiguous symptomatology involving difficulties with breathing, cough and fatigue 11 . Dyspnea as the most com- mon tracheal IMT clinical symptom is manifested early in the course of illness because of the tracheal obstruction 10 .…”

“…Identifying an IMT preoperatively is hindered because of its cellular pleomorphism feature even after an adequate bronchoscopy 11,13 . Its diagnosis is ordinarily being confirmed after the surgical resection 13 .…”

An Endobronchial Inflammatory Myofibroblastic Tumor Treated by Modified Left One-stoma-type Carinoplasty

“…In general, complete resection results in a better prognosis [2,7], but a few delayed recurrence after surgical resection implies the need for long-term follow-up.…”

Lymphocytic Interstitial Pneumonia and Other Benign Lymphoid Disorders

“…60,68 Calcification and cavitation can be seen but are uncommon. 74,75 Some lesions may exhibit endobronchial growth. 76 On FDG-PET scanning, IPT exhibits FDG uptake with a maximum standardized uptake value (SUV) values up to 21.…”