Surgical Management of Renal Papillary Necrosis

Hendry, W F; Harrison, Anna L.; Kilpatrick, F. R.

doi:10.1177/003591577206501157

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ureteric obstruction in analgesic nephropathy may be due to blockage by separated papillae or stones (Hendry et al, 1972), but in these patients there was no evidence of intraluminal obstruction on ureterography and this was confirmed in the two patients who underwent surgical exploration. The findings indicate that they had ureteritis with fibrosis of the ureter and, in one case, of the periureteric tissues.…”

Section: Discussionmentioning

confidence: 72%

Ureteric Stricture with Analgesic Nephropathy

MacGregor¹,

Jones²,

Barraclough³

et al. 1973

BMJ

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 72%

Ureteric Stricture with Analgesic Nephropathy

MacGregor¹,

Jones²,

Barraclough³

et al. 1973

BMJ

View full text Add to dashboard Cite

Analgesic nephropathy: Etiology, clinical syndrome, and clinicopathologic correlations in Australia

Nanra

Stuart-Taylor

Leon

et al. 1978

Kidney International

126

View full text Add to dashboard Cite

Analgesic abuse is a major public health hazard in Australia, and analgesic nephropathy with consequent terminal renal failure is the underlying cause in 20% of the patients requiring dialysis and transplantation. Analgesics are invariably taken in the form of compounds and mixtures. In the aspirin-phenacetin-caffeine (APC) mixture, aspirin appears to be the major nephrotoxic agent and phenacetin appears to play a secondary and synergistic role. The renal disease associated with abuse of analgesics is characteristic and is part of a much wider clinical syndrome, the analgesic syndrome, which includes peptic ulcer disease (35%), anemia (60 to 90%), hypertension (15 to 70%), ischemic heart disease (35%), psychological and psychiatric manifestations, pigmentation, and possible gonadal- and pregnancy-related effects. The primary lesion in analgesic nephropathy is renal papillary necrosis (RPN), and this is a nephrotoxic effect common to all nonsteroid antiinflammatory agents. The most important factor in the management of patients with analgesic nephropathy is the cessation of analgesic abuse, and this leads to improvement and stabilization of renal function. A small proportion of patients will, however, deteriorate in relation to accelerated hypertension, persistent proteinuria, ischemic heart disease, and complications leading to nephrectomy. Patients with analgesic nephropathy are poor risk patients and have a poor prognosis, even after dialysis and transplantation.

show abstract