Surgical manifestations of eosinophilic gastroenteritis in the pediatric patient

Disseminated eosinophilic infiltration of a newborn infant, with perforation of the terminal ileum and bile duct obstruction.

“…The infant lived for only 4 Disseminated eosinophlilic infiltration of a newborn infant 69 that such a widespread and severe eosinophilia could be an allergic response to the reconstituted milk with which he had been fed for 48 hours before the sudden collapse. The membranes had been ruptured for several hours before delivery but in the absence of inflammatory cell infiltration of the lungs this is an unlikely cause of the abnormal cellular infiltration of other tissues.…”

Pediatric patients with eosinophilic esophagitis: An 8-year follow-up

“…10,14,15 The effect of treatment of EE has been assessed on a short-term outcome only, with few data regarding the long-term prognosis of the disorder and its natural history in children. 2,5,6,8,9,11,14,[16][17][18][19][20][21] We conducted a retrospective review of our database of pediatric patients with EE, confirmed by histopathology of esophageal biopsies, and who have had follow-up. We aimed to describe the clinical syndrome, its natural history, and response to therapy; delineate the extent of histopathology in all segments of the gastrointestinal tract; and delineate the rate of relapse of tissue eosinophilia after the esophageal histology had become normal.…”

“…1 In initial case series of eosinophilic gastroenteritis, the brunt of the disease occurred in the stomach, duodenum, and colon. [2][3][4][5][6][7] Gradually, eosinophilic esophagitis (EE) emerged as a clinical entity after several reports separated EE from gastroesophageal reflux on the basis of the number of eosinophils per high-power field (hpf) on histopathology. [8][9][10][11] Because the normal esophagus is devoid of eosinophils, the presence of a high number of eosinophils in histopathology of the esophagus has become accepted as the histopathologic criterion for the diagnosis of EE.…”

Allergic and Eosinophilic Gastrointestinal Disease

“…77 There have also been reports of serosal infiltration with eosinophils, with associated complaints of abdominal distention, eosinophilic ascites and bowel perforation. 73,[78][79][80][81][82] …”