Surgical-orthodontic treatment for severe malocclusion in a patient with osteopetrosis and bilateral cleft lip and palate:

Kim, Jinkyu; Kim, Junyoung; Jung, Hyo Young; Jung, Young-Soo

doi:10.2319/080320-678.1

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Patient was educated to continue to use retainers regularly and to have regular check-ups with an orthodontist at least once every six months to assess the condition of the teeth so that good treatment results can be maintained. 16,17 Treatment for this patient with Class III malocclusion and cleft lip and palate was a challenge. The multidisciplinary approach resulted in significant improvements to facial and dental esthetics, and function was improved as well.…”

Section: Discussionmentioning

confidence: 99%

“…The choice of retainer used may vary depending on the situation. 17 A recently published, evidence-based, clinical practice guideline on CLP recommends maintaining the anterior teeth positions with a fixed retainer, and in addition, using a removable orthodontic retainer, such as a Hawley retainer, to preserve the maxillary transverse dimensions. 18 Such a retainer must be worn on a nightly basis, lifelong.…”

Section: Discussionmentioning

confidence: 99%

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Interdisciplinary management of Class III malocclusion with cleft lip and palate

et al. 2023

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Background: A cleft lip and palate (CLP) is one of the most common birth defects of the face. Individuals with CLP often have a significant growth disturbance of the maxilla along three dimensions, resulting in skeletal Class III malocclusion and cross bite. Oral rehabilitation can be complicated. Purpose: The purpose of this case study was to highlight the necessity of sequential interdisciplinary management to improve facial esthetics and correct functional disturbances for a patient with CLP. Case: The patient was a 20-year-old woman complaining of the unpleasant appearance of her upper front teeth. She had a concave profile with Class III skeletal patterns (SNA: 78O; SNB: 82O; ANB: -4O), cleft lip and palate, and an anterior and posterior crossbite. Case Management: A combined orthodontic, endodontic, conservative, periodontic, and prosthetic approach was proposed to achieve normal occlusion, function, and a harmonious profile. The combination of rapid maxillary expansion and fixed orthodontics (standard edgewise appliance) established good general alignment and a Class I relationship. After 15 months of treatment, both the posterior and anterior crossbite had been completely corrected. In order to address the gingival margin differences, the patient was instructed to make another appointment with the periodontist and was referred to the restorative dentist for veneer restorations and the prosthodontist for fabrication of a removable retainer with obturator. Conclusion: This interdisciplinary approach greatly improved both esthetics and function. The patient was satisfied with the results achieved.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interdisciplinary management of Class III malocclusion with cleft lip and palate

et al. 2023

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“…Environmental factors, such as illnesses, poor oral hygiene, disorders involving dental replacement, trauma, periodontal disease and other causes, can also sontribute to malocclusion. 13,14 Patients' oral health, facial appearance and oral function are all negatively impacted by malocclusion. As previously reported, there is a strong correlation between gingival inflammation and P.g and its gingipains.…”

Section: Discussionmentioning

confidence: 99%

Effects of orthodontic treatment on porphyromonas gingivalis, gingipains and gingival inflammation

Wang,

Zhang

et al. 2023

Eur J Inflamm

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Purpose: To assess the effects of orthodontic treatment on the changes of Porphyromonas gingivalis ( P.g) and gingipains as well as gingival inflammation. Materials and methods: A total of 105 patients who had healthy gingivae and were treated as research subjects, the gingival crevicular fluid of whom was all collected before treatment and in the 1st, 2nd, 3rd, and 6th months after wearing an appliance. Then, the 16S ribosomal deoxyribonucleic acid (rDNA) polymerase chain reaction (PCR) technique was employed to detect the levels of P.g, Lys-gingipain (Kgp) and Arg-gingipain (Rgp) in the specimens. It was followed by a statistical analysis of the data via the SPSS 23.0 software package. Results: In P.g detection, the 16S rDNA PCR technique presented specific advantages and high sensitivity. The positive detection rate of P.g in the 1st, 2nd and 3rd month of treatment ( p < .05), that of Kgp in P.g-positive patients in the 2nd and 3rd months of treatment ( p < .05), and that of Rgp in P.g-positive patients in the 2nd and 3rd months of treatment ( p < .05) were higher than the pre-treatment results. Compared with gingival index (GI)-0 patients, GI-1 patients exhibited higher positive detection rates of P.g and Kgp and Rgp, which were further found to be positively correlated with the treatment duration and GI ( p < .05). Conclusion: In the early stage of orthodontic treatment, the levels of P.g, Kgp and Rgp rise after wearing the appliance, inducing gingival inflammation.

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“…Up until recently, functional osteoclast abnormalities were considered the only factor contributing to osteopetrosis in humans. Although the cause of this is unknown, most mutations that impact the production of osteoclasts in humans are probably embryonically fatal [5]. The mutations in genes that encode enzymes involved in the acidic erosion process in the lacuna between the bone matrix and osteoclasts account for the vast majority of osteopetrosis cases.…”

Section: Introductionmentioning

confidence: 99%

Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review

Alkhayal

Shinwari

Gaafar

et al. 2023

CIMB

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Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and roots, and lamina dura thickening. Since deficiency of carbonic anhydrase II is a major cause behind osteopetrosis, carbonic anhydrase II activators have a large number of applications in osteopetrosis treatment. There is a lack of a comprehensive review on osteopetrosis, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. To address this research gap, the authros perfomed a comprehensive review on osteopetrosis and its types, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. A brief introduction to the pathogenesis of dental abnormalities and regeneration is provided in this survey. A discussion of types of osteopetrosis depending on genetic inheritance, such as autosomal dominant, autosomal recessive, and X-linked inheritance osteopetrosis, is presented in this survey. The paper also focuses on the importance of carbonic anhydrase II activators as a potential drug therapy for dental osteopetrosis. In addition, a brief note on the role of azole and fluconazole in treating osteopetrosis is given. Finally, future directions involving gene therapy for dental osteopetrosis are described.

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Surgical-orthodontic treatment for severe malocclusion in a patient with osteopetrosis and bilateral cleft lip and palate:

Cited by 4 publications

References 15 publications

Interdisciplinary management of Class III malocclusion with cleft lip and palate

Interdisciplinary management of Class III malocclusion with cleft lip and palate

Effects of orthodontic treatment on porphyromonas gingivalis, gingipains and gingival inflammation

Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review

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