Surgical outcome of deep anterior lamellar keratoplasty with air-assisted manual dissection for corneas with previous inflammation or fibrosis

Abstract

PURPOSE:To report our experience in air-assisted manual dissection deep anterior lamellar keratoplasty (DALK) for the treatment of corneal scar with previous inflammation and fibrosis.MATERIALS AND METHODS:We retrospectively reviewed the medical history of 21 patients (male:female = 13:8 mean age 41.9 years old) with corneal pathology from previous infection and inflammation. Trephination diameter ranged from 7.0 to 8.0 mm, and the graft was oversized by 0.25–0.50 mm. Debulking technique was performed to expose Descemet's membrane after filling stroma with air. Starting from postoperative 3 months, selective suture removal was performed to reduce corneal astigmatism.RESULTS:The mean follow-up period was 59.9 ± 19.8 (20–96) months. Intraoperative microperforation occurred in 2 eyes (9.5%); however, there was no shift to penetrating keratoplasty. Air-bubble tamponade was performed in 7 eyes (33.3%) for postoperative gapping of the graft. There were 2 failed grafts (9.5%) due to corneal ulcer while all the other grafts remained clear throughout follow-up. The mean preoperative best-corrected visual acuity (BCVA) was 1.84 ± 0.66 logMAR, which improved to 0.74 ± 0.63 (P < 0.01). The average sphere power was − 0.88 ± 3.88 diopter (D), average cylinder power 3.03 ± 1.46D, and average endothelial count 1877 ± 375 cells/mm2.CONCLUSION:In severe ocular surface diseases, big-bubble technique frequently failed to separate predescemtic plane; however, it effectively created air-filled stroma which was easier to remove. Although BCVA was suboptimal due to ocular surface disorders, graft survival and clarity rate is high, justifying the application of DALK in these cases.

Outcome of deep anterior lamellar keratoplasty patients with intraoperative Descemet's membrane perforation: A retrospective cross-sectional study

“…[ 16 17 ] Many modifications of the technique have also been described and have been useful for DALK. [ 18 19 20 ] In case of a failed big bubble, manual dissection may be required to carry out the stromal dissection. [ 21 ] In our study, we found that DM perforation can occur at any stage of the surgery and the surgeon ought to be extremely careful for the same.…”

Deep anterior lamellar keratoplasty: A surgeon's guide

“…Thus, big bubble technique, though commonly fails to separate predescemtic plane, effectively creates air-filled stroma, which is easier to remove. 68 Manual DALK by intrastromal air injection had also been described for postherpetic leukoma opacity. It had a safe intraoperative profile and resulted in significant visual recovery.…”

Main issues in deep anterior lamellar keratoplasty: A systematic narrative review

“…[ 49 ] Air-assisted manual dissection has demonstrated efficacy in cases of scarring due to inflammation and fibrosis, with confocal microscopy supporting comparable results. [ 8 50 ]…”