Surgical Outcome of Stage III and IV Adrenocortical Carcinoma

Ohwada, Susumu; Izumi, Masaru; Kawate, Susumu; Hamada, Kunihiro; Toya, Hiroyuki; Togo, Nozomi; Horiguchi, Jun; Koibuchi, Yukioi; Takahashi, Toru; Yamada, Masanobu

doi:10.1093/jjco/hyl127

Cited by 18 publications

(14 citation statements)

References 17 publications

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“…However, because up to 10% of adrenocortical carcinomas and 49% of metastasis can occur bilaterally [2,16,17] and sometimes cause adrenal insufficiency [18], an accurate differentiation between tuberculosis and malignancy may be radiologically and clinically difficult without surgical confirmation. Moreover, as in our case, the presence of adjacent organ invasion at the preoperative CT might increase suspicion of adrenal malignancy [5,16].…”

Section: Discussionsupporting

confidence: 47%

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Adrenal tuberculosis mimicking a malignancy by direct hepatic invasion: emphasis on adrenohepatic fusion as the potential route

Kim

Park

et al. 2015

Clinical Imaging

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Section: Discussionsupporting

confidence: 47%

“…When these typical radiologic and clinical manifestations occur together, the correct diagnosis of adrenal tuberculosis is likely. However, in adrenal tuberculosis, the direct invasion to adjacent organs has not been reported but is instead suggestive of advanced stage of adrenal malignancy [5].…”

Section: Discussionmentioning

confidence: 99%

Adrenal tuberculosis mimicking a malignancy by direct hepatic invasion: emphasis on adrenohepatic fusion as the potential route

Kim

Park

et al. 2015

Clinical Imaging

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“…5 Owada et al reported liver resection in 6 patients as 4 segmentectomies and 2 extended right hepatectomies. 14 All had R0 resections. In our series, 27 patients with ACC metastatic to the liver underwent 19 liver resections and 8 RFA procedures (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…4,8,13 Resection of liver metastases has been reported, but most series are small or combine resections of other distant sites. 5,14,15 …”

mentioning

confidence: 99%

Liver Resection and Ablation for Metastatic Adrenocortical Carcinoma

et al. 2011

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Background Adrenocortical carcinoma (ACC) is a rare disease without effective chemotherapy treated most appropriately with resection. The aim of this study was to evaluate our experience with liver resection for metastatic ACC. Methods This study is a retrospective review of patients who underwent liver resection or radiofrequency ablation (RFA) for ACC from 1979 to 2009. Results A total of 27 patients were identified. Of the 27, 19 underwent liver resection. Of the 19, 10 had a single liver lesion, and 18 of 19 were rendered free of disease in the liver, although only 11 of 19 were rendered completely free of disease because of extrahepatic disease (EHD). Of the 19, 13 had synchronous EHD. Also, 6 of 17 remained disease free in the liver at a median follow-up of 6.2 years (status of 2 of 19 was unknown). Of the 27 patients, 8 underwent RFA, 7 of 8 became free of disease in the liver, and 5 of 7 had EHD. No patients responded to prior chemotherapy. Median overall survival and survival of patients who underwent liver resection or RFA were both 1.9 years (0.2–12 + years); 5-year actuarial survivals were 29% and 29%, respectively. Disease-free interval (DFI) greater than 9 months from primary resection was associated with longer survival (median 4.1 vs 0.9 years; P = .013). Conclusions This study is a tertiary institution series of liver resection and RFA for ACC. Given the lack of effective systemic treatment options and the safety of resection and ablation, liver resection or RFA may be considered in selected patients with ACC metastatic to the liver especially with a long DFI.

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“…Surgery is considered to be the only method to cure ACC of in the early stage [7,8,9,10]. There were 15 cases of ACC in stages I and II in total.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management and Clinical Prognosis of Adrenocortical Carcinoma

Dong

Li²,

Yan³

et al. 2012

Urol Int

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Objective: To study the relationship between surgical management and prognosis of adrenocortical carcinoma (ACC) in order to guide the surgical management of ACC. Methods: Clinical data of 45 cases of ACC treated in our hospital were retrospectively analyzed. The 45 cases included 3 cases in stage I, 12 cases in stage II, 7 cases in stage III, and 23 cases in stage IV. 17 cases underwent complete excision, 14 cases underwent palliative excision, 8 cases had non-operative treatment and 6 cases gave up treatment. All patients were followed up from 2 to 141 months. Results: The average survival time of 31 patients with surgery was 32.46 months, and the average survival time of 14 patients without surgery was 4.75 months. There were statistically significant differences between the two groups (p < 0.01). There were no statistically significant differences between the two groups in survival time in stage III and stage IV (p > 0.05). Conclusions: Surgery is considered to be the only method to cure ACC. For ACC in stage I and II, tumor resection is the most effective treatment, and second surgical operation is recommended for local recurrence. For ACC in stage III, extensive surgical operation is recommended, and for ACC in stage IV, surgical operation has no effect on the prognosis.

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Surgical Outcome of Stage III and IV Adrenocortical Carcinoma

Abstract: Resection for stage III, IV ACCs affords the possibility of negative margins, acceptable peri-operative morbidity and mortality, and prolongs survival in selected patients.

Cited by 18 publications

References 17 publications

Adrenal tuberculosis mimicking a malignancy by direct hepatic invasion: emphasis on adrenohepatic fusion as the potential route

Adrenal tuberculosis mimicking a malignancy by direct hepatic invasion: emphasis on adrenohepatic fusion as the potential route

Liver Resection and Ablation for Metastatic Adrenocortical Carcinoma

Surgical Management and Clinical Prognosis of Adrenocortical Carcinoma

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