Surgical Outcomes for Hepatocellular Carcinoma in Patients with Child–Pugh Class B: a Retrospective Multicenter Study

Tanaka, Shogo; Noda, Takehiro; Koyama, Koji; Kosaka, Hisashi; Iida, Hiroya; Ueno, Masaki; Hokuto, Daisuke; Ikoma, Hisashi; Nakai, Toshiko; Kabata, Daijiro; Shinkawa, Hiroji; Kobayashi, Shogo; Hirokawa, Fumitoshi; Mori, Haruki; Hayami, Shinya; Morimura, Ryo; Matsumoto, Masataka; Ishizawa, Takeaki; Kubo, Shoji; Kaibori, Masaki

doi:10.1007/s11605-022-05549-w

Cited by 5 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study also suggested that cirrhosis is a risk factor for postoperative survival in patients with AFP-negative HCC and may be associated with the underlying malignant transformation of cirrhosis. The severity of liver dysfunction is strongly correlated with the progression and prognosis of HCC [32]. The Child-Pugh classi cation is a routine practice for evaluating liver function in patients with HCC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic performance of MRI LI-RADS version 2018 features and clinical-pathological factors in alpha-fetoprotein-negative hepatocellular carcinoma

Wang,

Feng,

Liang

et al. 2024

Abdom Radiol

View full text Add to dashboard Cite

To evaluate the performance of the magnetic resonance imaging (MRI) Liver Imaging Reporting and Data System (LI-RADS) version 2018 features and clinical-pathological factors for predicting the prognosis of alpha-fetoprotein (AFP)-negative (≤ 20 ng/ml) hepatocellular carcinoma (HCC) patients, and to compare with other traditional staging systems. MethodsWe retrospectively enrolled 169 patients with AFP-negative HCC who received preoperative MRI and hepatectomy between January 2015 and August 2020 (derivation dataset: validation dataset = 118: 51). A prognostic model was constructed using the risk factors identi ed via Cox regression analysis. Predictive performance and discrimination capability were evaluated and compared with those of two traditional staging systems. ResultsSix risk factors, namely the LI-RADS category, blood products in mass, microvascular invasion, tumor size, cirrhosis, and albumin-bilirubin grade, were associated with recurrence-free survival. The prognostic model constructed using these factors achieved C-index of 0.705 and 0.674 in the derivation and validation datasets, respectively. Furthermore, the model performed better in predicting patient prognosis than traditional staging systems. The model effectively strati ed patients with AFPnegative HCC into high-and low-risk groups with signi cantly different outcomes (p < 0.05). ConclusionsA prognostic model integrating the LI-RADS category, blood products in mass, microvascular invasion, tumor size, cirrhosis, and albumin-bilirubin grade may serve as a valuable tool for re ning risk strati cation in patients with AFP-negative HCC.

show abstract

Section: Discussionmentioning

confidence: 99%