Surgical outcomes of major hepatectomy following “radiation lobectomy” for hepatic malignancies and insufficiently functional future liver remnant: initial experience

Andel, Dorinde M. van; Dassen, M.; Reinders-Hut, M T M; Peters, Niek A.; Kranenburg, Onno; Lam, Marnix G. E. H.; Hagendoorn, Jeroen; Rinkes, Inne H.M. Borel

doi:10.1002/bjs.11828

Cited by 4 publications

(5 citation statements)

References 7 publications

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“… 49 We and others have recently demonstated that major hepatectomy following RL can be safely performed. 7 In light of these and the present results, we speculate that RL could control tumor growth and further spread while waiting for future liver remnant hypertrophy.…”

Section: Discussionsupporting

confidence: 65%

“… 2 In both HCC and CRLM, radioembolization can be used as neoadjuvant treatment for patients that are deemed unresectable due to insufficiency of the future liver remnant. [4] , [5] , [6] , [7] In these cases, high-dose, unilobar treatment may induce ipsilateral atrophy (thus termed ‘radiation lobectomy’ [RL]) and contralateral hypertrophy of the future liver remnant, while simultaneously treating the tumor. 5 …”

Section: Introductionmentioning

confidence: 99%

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90Y-/166Ho- ‘Radiation lobectomy’ for liver tumors induces abnormal morphology and impaired drainage of peritumor lymphatics

Andel,

van den Bent,

Ernest Hendrik Lam

et al. 2024

JHEP Reports

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

90Y-/166Ho- ‘Radiation lobectomy’ for liver tumors induces abnormal morphology and impaired drainage of peritumor lymphatics

Andel,

van den Bent,

Ernest Hendrik Lam

et al. 2024

JHEP Reports

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“…Vouche et al [ 74 ] reported 45% of FLR hypertrophy and observed a correlation between the presence of a portal vein thrombosis and FLR growth. However, series reporting major liver resection after RL are scarce[ 76 , 77 ]. Andel et al [ 77 ] recently reported 10 major hepatectomies in patients that were initially treated with RL for insufficient functional FLR.…”

Section: Radiation Lobectomymentioning

confidence: 99%

“…However, series reporting major liver resection after RL are scarce[ 76 , 77 ]. Andel et al [ 77 ] recently reported 10 major hepatectomies in patients that were initially treated with RL for insufficient functional FLR. The RL allowed a 41% increase in FLR volume with 84% of FLR function increase (evaluated on scintigraphy).…”

Section: Radiation Lobectomymentioning

confidence: 99%

Current strategies to induce liver remnant hypertrophy before major liver resection

Basso¹,

Gaillard²,

Laïnas³

et al. 2021

WJH

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Hepatic resection is the gold standard for patients affected by primary or metastatic liver tumors but is hampered by the risk of post-hepatectomy liver failure. Despite recent improvements, liver surgery still requires excellent clinical judgement in selecting patients for surgery and, above all, efficient pre-operative strategies to provide adequate future liver remnant. The aim of this article is to review the literature on the rational, the preliminary assessment, the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.

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“…Hepatectomy is the most popular radical treatment for hepatic malignancies which offers resectable patients better survival rates. 1 , 2 However, hepatectomy is also associated with numerous complications including bleeding, acute liver failure and bile leakage … which can adversely affect survival result and mortality rate. 3 …”

Section: Introductionmentioning

confidence: 99%

Hepatectomy with Takasaki’s Technique Using SonaStar Ultrasonic Aspiration System: An Experience from 58 Cases

Hồ¹,

Nguyen²,

Tran³

et al. 2021

CEG

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Objective This study aims to explore the short-term results of hepatectomy with Takasaki’s technique using Sonastar ultrasonic aspiration system. Materials and Methods We retrospectively examined data of 58 patients who underwent hepatectomy with Takasaki’s technique using Sonastar ultrasonic aspiration system at Hue Central Hospital from 01/2018 to 02/2021. Results The mean age was 60.7 ± 10.5 years (25–80) and the male/female ratio was 6:1. Patients with solitary tumor accounted for 79%; 68.4% had tumor size greater than 5 cm. Pringle maneuver was used in 57.9%, while selective right or left Glissonean pedicle occlusion was used in 69.0% and 32.8%, respectively. Final transection surface reinforcement was achieved by Surgicel and BioGlue in 78.9% and 21.5% of cases, respectively. Major liver resection accounted for 73.7%. The mean parenchymal transection time was 50 (45–110) minutes, while mean total operative time was 125 (90–280) minutes. Mean operative blood loss was 250 (150–650) mL. Mean post-operative hospital stay was 8 days (7–23). Post-operative complication rate was 15.9% and mortality rate was 1.7%. Conclusion Hepatectomy using Takasaki technique with Sonastar ultrasonic aspiration system is safe, effective, allowing an anatomical resection with sufficient safety margin and resulting in low complication rates (liver failure, biliary leakage) and good survival outcomes.

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Surgical outcomes of major hepatectomy following “radiation lobectomy” for hepatic malignancies and insufficiently functional future liver remnant: initial experience

Cited by 4 publications

References 7 publications

90Y-/166Ho- ‘Radiation lobectomy’ for liver tumors induces abnormal morphology and impaired drainage of peritumor lymphatics

90Y-/166Ho- ‘Radiation lobectomy’ for liver tumors induces abnormal morphology and impaired drainage of peritumor lymphatics

Current strategies to induce liver remnant hypertrophy before major liver resection

Hepatectomy with Takasaki’s Technique Using SonaStar Ultrasonic Aspiration System: An Experience from 58 Cases

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