Surgical outcomes of myelomeningocele repair: A 20-year experience from a single center in a middle-income country

Zoghi, Sina; Feili, Maryam; Mosayebi, Mohammad Amin; Ansari, Ali; Feili, Afrooz; Masoudi, Mohammad Sadegh; Taheri, Reza

doi:10.1016/j.clineuro.2024.108214

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Therefore, it is logical to expect a higher mortality rate in populations with low birth weight at birth and early surgery, as we demonstrated in this study. Additionally, there might be other hidden factors, such as ICU care and post-operative recovery, which could be more significant contributors to the elevated mortality rate but have not been discussed [13,14].…”

Section: Prognostic Factors and Intervention Strategiesmentioning

confidence: 99%

Prognostic risk factors for early outcomes of patients with myelomeningocele: a prospective study

Naseri Alavi,

Rezkhah,

Majdi

et al. 2024

Childs Nerv Syst

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Introduction Myelomeningocele (MMC) is a prevalent form of neural tube defect. Despite advancements in treatment, MMC still poses significant health risks, including complications leading to chronic disability and mortality. Identifying prognostic risk factors for early outcomes is crucial for tailored intervention strategies. Methods This prospective study involved newborns and infants diagnosed with MMC who underwent surgery between 2020 and 2023 at Urmia University of Medical Sciences. Demographic data and surgical outcomes were collected, and participants were followed up for six months. Statistical analyses were conducted using descriptive statistics, Chi-Square, and independent t-test. Results The study included 29 MMC cases, with an incidence rate of 1.4 per 10,000 live births. Lesions were predominantly located in the lumbar spine. Although mortality rates appeared to increase with ascending lesion sites, this trend was not statistically significant. Short-term outcomes revealed high morbidity and mortality rates, with neurological deficits being the most prevalent complication. Multivariable analysis identified head circumference as a significant predictor of adverse outcomes (IRR = 1.37, 95% CI = 1.02 to 1.86, p = 0.04). Furthermore, an increase in birth weight was associated with a reduction in the incidence of requiring a ventriculoperitoneal shunt (IRR = 0.99, 95% CI = 0.998 to 0.999, p = 0.02). Conclusion This prospective study highlights prognostic risk factors for early outcomes in MMC patients, emphasizing the need for personalized intervention strategies. By addressing modifiable risk factors and implementing targeted interventions, healthcare providers can strive to improve outcomes and enhance the quality of life for MMC patients.

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Section: Prognostic Factors and Intervention Strategiesmentioning

confidence: 99%

Prognostic risk factors for early outcomes of patients with myelomeningocele: a prospective study

Naseri Alavi,

Rezkhah,

Majdi

et al. 2024

Childs Nerv Syst

View full text Add to dashboard Cite

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Prognostic Risk Factor for Early Outcomes of Patients with Myelomeningocele: A Prospective Study

Alavi,

Rezkhah,

Majdi

et al. 2024

Preprint

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Introduction: Myelomeningocele (MMC) is a prevalent form of neural tube defect. Despite advancements in treatment, MMC still poses significant health risks, including complications leading to chronic disability and mortality. Identifying prognostic risk factors for early outcomes is crucial for tailored intervention strategies. Methods This prospective study involved newborns and infants diagnosed with MMC who underwent surgery between 2020 and 2023 at Urmia University of Medical Sciences. Demographic data and surgical outcomes were collected, and participants were followed up for six months. Statistical analyses were conducted using descriptive statistics, Chi-Square, and independent t-test. Results The study included 29 MMC cases, with an incidence rate of 1.4 per 10,000 live births. Lesions were predominantly located in the lumbar spine. Although mortality rates appeared to increase with ascending lesion sites, this trend was not statistically significant. Short-term outcomes revealed high morbidity and mortality rates, with neurological deficits being the most prevalent complication. Multivariable analysis identified head circumference as a significant predictor of adverse outcomes (IRR = 1.37, 95% CI = 1.02 to 1.86, p = 0.04). Furthermore, an increase in birth weight was associated with a reduction in the incidence of requiring a ventriculoperitoneal shunt (IRR = 0.99, 95% CI = 0.998 to 0.999, p = 0.02) Conclusion This prospective study highlights prognostic risk factors for early outcomes in MMC patients, emphasizing the need for personalized intervention strategies. By addressing modifiable risk factors and implementing targeted interventions, healthcare providers can strive to improve outcomes and enhance the quality of life for MMC patients.

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Surgical outcomes of myelomeningocele repair: A 20-year experience from a single center in a middle-income country

Cited by 2 publications

References 31 publications

Prognostic risk factors for early outcomes of patients with myelomeningocele: a prospective study

Prognostic risk factors for early outcomes of patients with myelomeningocele: a prospective study

Prognostic Risk Factor for Early Outcomes of Patients with Myelomeningocele: A Prospective Study

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