Surgical Pathology of the Foot and Clinicopathologic Correlations

O’Neal, Lawrence W.

doi:10.1016/b978-0-323-04145-4.50025-9

Cited by 18 publications

(96 citation statements)

References 20 publications

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“…According to their initial description, each angiosome encompasses twin arteriosomes and venosomes for blood supply, all being interconnected in a vast compensatory system (the"choke vessels") (Attinger et al, 2006;Taylor et al, 1998). The arterial side of this "rescue network" relying on adjacent angiosomes seems particularly damaged in ESRD/diabetic patients exhibiting peculiar medium-sized collaterals depletion by aggressive atherosclerosis joined to small arterial septic thrombosis (the already reported "end artery occlusive disease" pattern) (O'Neal, 2008). Unlike the arteries, deep calf veins and collaterals seem less affected by this occlusive process (Alexandrescu et al, 2011;Krisnan & Rayman, 2008).…”

Section: Discussionmentioning

confidence: 99%

Is Limb Loss Always Inevitable for Critical Neuro-Ischemic Foot Wounds in Diabetic Patients with End Stage Renal Disease and Unfit for Vascular Reconstructions?

Alexandrescu¹

2012

Diseases of Renal Parenchyma

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Section: Discussionmentioning

confidence: 99%

Is Limb Loss Always Inevitable for Critical Neuro-Ischemic Foot Wounds in Diabetic Patients with End Stage Renal Disease and Unfit for Vascular Reconstructions?

Alexandrescu¹

2012

Diseases of Renal Parenchyma

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“…The EAOD theory emphasizes that in the collateral-depleted diabetic limb, "each millimeter of skin" up to the "entire foot" may rely upon one particular artery with terminal distribution [59], while this valuable vessel may be auspiciously targeted by "wound directed" revascularization, according to the angiosome concept [24][25][26].…”

Section: Does Healing Process In Diabetics Follow Same Predictable "Smentioning

confidence: 99%

“…To date, the prevalence of purely neuropathic, ischemic, and combined neuro-ischemic foot ulcers in patients with diabetes was estimated at 35, 15, and 50% rates, respectively [57][58][59].…”

Section: Does Healing Process In Diabetics Follow Same Predictable "Smentioning

confidence: 99%

“…Modern diabetic ulcer understanding builds a complete design of multifaceted and potentially devastating CLI effects in these patients [2,31,[57][58][59][60][61][62].…”

Section: Does Healing Process In Diabetics Follow Same Predictable "Smentioning

confidence: 99%

“…Reported DFS singularities include (1) the regular tibial trunks calcifications [2,30,31,57] that match the extent of local neuropathy [25,31], (2) the "end-artery occlusive disease" (EAOD) concept [59], (3) an impaired arterio-and angiogenesis [60], (4) a specific collateral deprivation following chronic inflammation and septic thrombosis of small vessels [31,35,[57][58][59], (5) intrinsic vascular or matrix impaired regeneration [61], and (6) characteristic neuro-ischemic compartmental hyper pressure foot syndromes [62].…”

Section: Does Healing Process In Diabetics Follow Same Predictable "Smentioning

confidence: 99%

See 2 more Smart Citations

Ischemic Ulcer Healing: Does Appropriate Flow Reconstruction Stand for All That We Need?

Alexandrescu¹,

Triffaux²

2016

Wound Healing - New Insights Into Ancient Challenges

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During the recent decades, soaring progresses in vascular disease knowledge, particularly in critical limb ischemia (CLI) treatment, enhanced novel diagnostic and interventional strategies with high serviceableness in patient's selection, arterial recanalization, and dedicated ischemic ulcer follow-up. However, despite undeniable advances in medical technology and clinical judgment, limb salvage, the ambulation recovery, and patient's survival seem only scarcely affected in this heterogeneous CLI group, particularly concerning the diabetic and renal patients. Innovative strategies such as "end artery occlusive disease" treatment or "wound-targeted revascularization" were equally proposed by following the angiosomal anatomical distribution associating individual foot collateral assessment in a unified macro-and micro-circulatory judgment. However, despite encouraging clinical results, prospective evidence still lacks on this concern. It also appears that specific wounds could not always stand for the lowest perfusion areas according to current CLI criteria, since severe neuropathy, inflammatory swelling, local infection, and skin trauma may add complementary hindrances to tissue viability.The present chapter endeavor to summarize main available treatment principles for ischemic ulcer recovery that every modern practitioner eventually disposes in an updated contemporary view."

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Risk Factors for Lower Extremity Amputation in Patients with Diabetic Foot Ulcer

Pemayun

Naibaho

2017

Pressure Injury, Diabetes and Negative Pressure Wound Therapy

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Surgical Pathology of the Foot and Clinicopathologic Correlations

Cited by 18 publications

References 20 publications

Is Limb Loss Always Inevitable for Critical Neuro-Ischemic Foot Wounds in Diabetic Patients with End Stage Renal Disease and Unfit for Vascular Reconstructions?

Is Limb Loss Always Inevitable for Critical Neuro-Ischemic Foot Wounds in Diabetic Patients with End Stage Renal Disease and Unfit for Vascular Reconstructions?

Ischemic Ulcer Healing: Does Appropriate Flow Reconstruction Stand for All That We Need?

Risk Factors for Lower Extremity Amputation in Patients with Diabetic Foot Ulcer

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