Surgical Pathology of the Mitral Valve: A Study of 712 Cases Spanning 21 Years

Olson, Lyle J.; Subramanian, Ramiah; Ackermann, D. Michael; Orszulak, Thomas A.; Edwards, William D.

doi:10.1016/s0025-6196(12)61522-5

Cited by 263 publications

(112 citation statements)

References 83 publications

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“…7 Mitral stenosis can lead to enlargement of the left atrium (LA) leading to increased risk of thrombus formation. 8 The frequency of leftatrial thrombi is between 20 and 33% according to the literature. 7 Left atrial thrombus is more frequently associated with embolic events.…”

Section: Introductionmentioning

confidence: 99%

The Factors Causing Left Atrial Appendage Clot Formation in Patients With Severe Rheumatic Mitral Stenosis

Bajwa¹,

Hyder²,

Aziz³

2016

Heart Res Open J

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CitationWe assessed the factors responsible for left atrial appendage clot formation in patients with severe mitral stenosis through transesophageal echocardiography Methods: An observational study was conducted among 82 (73 females, mean age 35.8±11.8 years) patients with severe mitral stenosis who underwent transesophageal echocardiography before percutaneous transmitral commisurotomy. Patients were classified into two groups based on the presence or absence of left atrial thrombus. Group l consisted of 24 patients (women to men ratio 91:9) with left atrial thrombus, while group 2 consisted of 58 patients (women to men ratio 88:12) without left atrial thrombus. Transesophageal echocardiographic findings were reviewed in all patients. Results: There was no significant difference between the two groups in terms of age, sex, systolic pulmonary artery pressure and mitral valve mean pressure gradient (MVMPG), there was significant difference regarding frequency of atrial fibrillation (p≤0.05), left atrial size (p≤ 0.05), mitral valve area andflow velocities (p≤0.05) in group-1 patients. Similarly, atrial fibrillation was observed in 35(42.7%) patients out of which 20(83.3%) patients had thrombus in left atrial appendage. Conclusion: The frequency of left atrial thrombus formation increased in patients with rheumatic mitral stenosis because of low left atrial appendage flow velocities, atrial fibrillation and smaller mitral valve area.

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Section: Introductionmentioning

confidence: 99%

The Factors Causing Left Atrial Appendage Clot Formation in Patients With Severe Rheumatic Mitral Stenosis

Bajwa¹,

Hyder²,

Aziz³

2016

Heart Res Open J

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“…1 About 25% of subjects are presented with isolated mitral stenosis (MS) and additional 40% are presented with combined mitral stenosis and regurgitation.…”

Section: Introductionmentioning

confidence: 99%

Severe Mitral Stenosis; In-Hospital Outcomes of Percutaneous Transvenous Mitral Commissurotomy (Ptmc) in Patients

Babar

Saad

Butt³

et al. 2017

TPMJ

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ABSTRACT… Objectives: To evaluate the immediate outcomes of PTMC in patients with severe mitral valve stenosis. Study Design: Cross-sectional study. Setting: Ninety (90) subjects who underwent PTMC in Cardiac Catheterization Department of CPE Institute of Cardiology. Period: June 2008 to June 2011. Methods: Patients with severe MS having mitral valve (MV) area <1.0 cm 2 and having morphology suitable for PTMC in the absence of regurgitation and left atrial clot were included in this study. An increase in mitral valve area more than 50% of the baseline area without the development of moderate to severe MR was considered as the procedural success. Data were analyzed using SPSS V19. Pre and post procedural outcomes were measured using paired sample t-test. Results: There were a total number of ninety (90) patients in this study. Mean age of subjects was 28.08+9.61 years. There were more females 59 (65.5%) as compared to only 31 (34.5%) males. There was significant increase in mitral valve area, 1.83+0.36 cm 2 post-PTMC versus 0.63+0.17 cm 2 pre-PTMC (p-value <0.001). There was significant decrease in Peak pressure gradient (PPG) from 28.31+6.01 mmHg to 12.85+3.20 mmHg after PTMC (p-value <0.001). There were also significant reductions in mean pressure gradient and pulmonary artery systolic pressures after PTMC with p-value <0.001 and <0.001 respectively. PTMC was successful in 87 (97.7%) patients and it failed in only 3 (3.3%) patients. Conclusion: PTMC is an excellent treatment option regarding optimal outcomes and success rate in patients of severe mitral stenosis especially when performed by experienced interventionists. Key words:Mitral Stenosis, Percutaneous Transvenous Mitral Commissurotomy (PTMC), rheumatic fever, rheumatic heart disease.

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“…1 Approximately 25% of patients with rheumatic heart disease (RHD) have isolated MS, and an additional 40% have combined MS and mitral regurgitation (MR). 2,3 Based upon the nature and severity of MS, patients can be managed with medical therapy, percutaneous transluminal mitral commissurotomy (PTMC) or surgery.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous Transluminal Mitral Commisuriotomy for Mitral Stenosis in Shahid Gangalal National Heart Centre, Kathmandu, Nepal

Adhikari

2016

Nepalese Heart J.

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Mitral stenosis (MS) is almost invariably the result of long term complication of rheumatic fever. Based upon the nature and severity of MS, patients can be managed with medical treatment, percutaneous transvenous mitral commissurotomy (PTMC) or surgery. PTMC is proven to be simple, effective and safe; it is considered as treatment of choice in the management of MS. In Shahid Gangalal National Heart Centre, PTMC service started in 2001. First PTMC in the centre was done on 14th April 2001. Till June2016, 6023 PTMCs were done in the centre. Multiple studies evaluated the safety and efficacy of PTMC in different groups of patients. These studies clearly demonstrated the safety and effectiveness of PTMC in our centre. This article summarizes the historical development, current status and future perspectives of PTMC procedure at Shahid Gangalal National Heart Centre, a teritary care cardiac centre in Nepal.Nepalese Heart Journal 2016; 13(2): 15-17

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Surgical Pathology of the Mitral Valve: A Study of 712 Cases Spanning 21 Years

Cited by 263 publications

References 83 publications

The Factors Causing Left Atrial Appendage Clot Formation in Patients With Severe Rheumatic Mitral Stenosis

The Factors Causing Left Atrial Appendage Clot Formation in Patients With Severe Rheumatic Mitral Stenosis

Severe Mitral Stenosis; In-Hospital Outcomes of Percutaneous Transvenous Mitral Commissurotomy (Ptmc) in Patients

Percutaneous Transluminal Mitral Commisuriotomy for Mitral Stenosis in Shahid Gangalal National Heart Centre, Kathmandu, Nepal

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