Surgical removal of the olfactory bulbs increases sensitivity of the reproductive system of female rats to the inhibitory effects of late afternoon melatonin injections

Reíter, Russel J.; Petterborg, Larry J.; Trakulrungsi, Chatchai; Trakulrungsi, Wantanee

doi:10.1002/jez.1402120107

Cited by 44 publications

(24 citation statements)

References 15 publications

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“…These data differ somewhat from those of Chik et al (1987b), who observed significant increases in circulating melatonin concentrations following isoproterenol treatment in both control and underfed rats, with the rise in melatonin occurring more gradually in underfed rats. Chik et al (1987b) Nocturnal secretion of melatonin provides animals with both a circadian and circa-annual message that provides a means of timing daily and seasonal events (Reiter 1991 Evidence from studies on the laboratory rat indicates that under certain conditions, including anosmia (Reiter et al 1980) and food restriction (Sorrentino et al 1971), this normally nonphotoperiodic species may be rendered reproductively photoresponsive. Circulating melatonin concentrations are increased in underfed rats (Chik et al 1987a), and the response to a p-agonist is also altered by underfeeding (Chik et al 1987b …”

Section: Dlscusslonmentioning

confidence: 99%

The effect of feed restriction and of a β-adrenergic agonist on plasma melatonin concentrations in domestic pigs

Peacock¹,

Thacker²,

Kirkwood³

et al. 1995

Can. J. Anim. Sci.

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Section: Dlscusslonmentioning

confidence: 99%

The effect of feed restriction and of a β-adrenergic agonist on plasma melatonin concentrations in domestic pigs

Peacock¹,

Thacker²,

Kirkwood³

et al. 1995

Can. J. Anim. Sci.

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“…play an important regulatory role in the diur nal rhythms of biological responses to mela tonin during certain periods of the day in hamsters [8], white-footed mice [36], rats [7] and sheep [37], However, Weaver et al [38] showed that both the melatonin-sensitive and nonsensitive species of mice have similar quality of [125I]iodomelatonin binding sites. The same condition was found in rats and hamsters which have the same amount of [l35l]iodomelatonin binding sites but differ ent melatonin sensitivities demonstrated by their reproductive system [39].…”

Section: Effects O F Melatonin Administration On Serum Melatonin Levementioning

confidence: 99%

“…3], Pineal melatonin secretion has a very pronounced circadian rhythm with a high level in the dark period in all species studied [4], There is also a prominent diurnal variation in the biological response to melatonin [5], The late photophase melatonin administration has been shown to be critical for the melatonin effects on the hypothalamo-pituitary-gonadal systems in an imals [6][7][8][9]. It has been suggested that the sen sitivity of melatonin receptors may play an important role in the diurnal changes of re sponsiveness of melatonin action [7.…”

mentioning

confidence: 99%

[<sup>125</sup>I]lodomelatonin Binding Sites in the Chicken Brain: Diurnal Variation and Effects of Melatonin Injection or Pinealectomy

Pang

1992

Biological Signals

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The diurnal variation of [¹²⁵I]iodomelatonin binding sites in the brain and serum melatonin levels were studied at 4-hour intervals under a 12h:12h light:dark cycle in 5-week-old chicks. There was a diurnal rhythm of [¹²⁵I]iodomelatonin binding capacities in brain membrane preparations with the peak in the light period and the trough in the dark period. However, a diurnal variation with high levels in the dark and low levels in the light was observed in serum melatonin concentrations. The binding capacity of [¹²⁵I]iodomelatonin was inversely related to the serum melatonin level. Four-week-old chicks were injected with melatonin (1 mg melatonin/kg; i.p.) twice a day (shortly after the light onset and shortly before light offset) for 3 weeks. When chickens were killed at 7 weeks, there was no diurnal rhythm of melatonin in the circulation. In addition, melatonin injection also abolished the diurnal variation of [¹²⁵I]iodomelatonin binding sites in brain membrane preparations in these animals. This was achieved by decreasing the binding capacity in the light period. Pinealectomy in 2-day-old chickens increased the density of [¹²⁵I]io-domelatonin binding sites in the brain membrane preparations both at midlight and middark when the chicks were later sacrificed at 6 weeks of age, although the rhythm of binding sites persisted. It is suggested that the [¹²⁵I]iodomelatonin binding capacity in the chicken brain is regulated by endogenous melatonin and influenced by exogenous melatonin. In addition, the rhythmicity of [¹²⁵I]iodomelatonin binding sites in the chicken brain is affected by, but not dependent on, pineal melatonin.

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“…The circadian rhythmicity of [l25I]melatonin binding in this and other tissues [32] may play an important regulatory role in the diurnal rhythms of responses to melatonin during certain periods of the day in hamsters [33] and rats [34]. However, several authors have shown that the melatonin sensitivity of the species is not related to quantity of [125I]melatonin binding sites [35], suggesting that the increased sensitivity to melatonin in animals is probably due to a difference in a postreceptor mechanism rather than to a dif ference in the density or affinity of the recep tors.…”

Section: Effect Of Castration On [125l]melatonin Binding By the Hardementioning

confidence: 99%

Melatonin Binding Sites in the Harderian Gland of the Rat and Syrian Hamster

Guerrero

Menéndez-Peláez²,

Calvo³

et al. 1994

Neurosignals

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Specific melatonin binding sites in the harderian gland of both rat and Syrian hamster were studied using [¹²⁵I]melatonin. In both species, binding of [¹²⁵I]melatonin by harderian gland membranes exhibited properties such as dependence on time, temperature, membrane concentration, saturability, and high specificity. Only one class of high-affinity binding sites was found with a Kd of 0.19 and 6.47 nM for the rat and Syrian hamster, respectively. The binding capacity in the rat harderian gland was 4.00 fmol/mg protein; in the Syrian hamster it was 7.58 fmol/mg protein. In the rat, no sex differences were found in the binding of the tracer to the membranes. However, in the Syrian hamster, binding of [¹²⁵I]melatonin by the harderian gland was twice higher in the female than in the male. No changes were found in the Kd values (6.47 vs. 6.94 nM), while binding capacity was significantly increased in the female (13.50 fmol/mg protein) when compared to the male hamster (7.58 fmol/mg protein). Binding of [¹²⁵I]melatonin by the harderian gland of male hamsters was modified by castration but not by melatonin treatment. Castration induced an increase of binding up to the level of females. However, chronic melatonin administration did not alter the [¹²⁵I]melatonin binding in either intact or gonadectomized male hamsters. Binding studies also showed diurnal variations. There was a diurnal rhythm of [¹²⁵I]melatonin binding by Syrian hamster harderian glands with the peak at the end of the light period and the trough late in the dark period. This rhythm in the binding is observed in both male and female hamsters, although binding in females was always higher than that in males. Serum melatonin levels also demonstrated a diurnal variation with a well-established nocturnal peak of melatonin at 4.00 h and a fall after light onset at 6.00 h. As it has been previously described, nocturnal levels of serum melatonin in the male Syrian hamster were higher than those of the female hamster. Results confirm the presence of melatonin binding sites in the harderian gland of rats and Syrian hamsters, suggesting that these binding sites may mediate, in addition to other effects, the regulation of melatonin in the harderian gland.

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Surgical removal of the olfactory bulbs increases sensitivity of the reproductive system of female rats to the inhibitory effects of late afternoon melatonin injections

Cited by 44 publications

References 15 publications

The effect of feed restriction and of a β-adrenergic agonist on plasma melatonin concentrations in domestic pigs

The effect of feed restriction and of a β-adrenergic agonist on plasma melatonin concentrations in domestic pigs

[<sup>125</sup>I]lodomelatonin Binding Sites in the Chicken Brain: Diurnal Variation and Effects of Melatonin Injection or Pinealectomy

Melatonin Binding Sites in the Harderian Gland of the Rat and Syrian Hamster

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