Distal femoral diaphyseal fractures in six dogs about 10-22 months old with body weight ranging from 12-25 kg were stabilized with String of Pearls (SOP) (Orthomed, UK) locking plates along with standard cortical and cancellous screws following standard AO/ASIF principles. Selection of appropriate size of plate and screws was according to body weight and type of fracture (2.7mm plate for dogs below 12 kg body weight and 3.5 mm plate for dogs above 12 kg body weight) which provided good fracture stability. The outcome of fracture stabilization and healing was evaluated with lameness grading and radiography. Postoperatively, all the animals showed weight bearing with early functional limb usage of grade I lameness and good joint mobility in an average of 7 weeks. Functional outcome was excellent in good in four cases and excellent in two cases. The average overall healing time in all the cases was 7-11 weeks. The fractures showed radiographically excellent postoperative healing of cortical union, absence of fracture lines with limited and also bridging callus. Based on present study, it was concluded that, String of Pearls (SOP) locking plates were good for stabilization of distal femoral diaphyseal fractures for early limb ambulance and healing.