Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats

Vanore, Maria; Chahory, Sabine; Payen, Guillaume; Clerc, Bernard

doi:10.1111/j.1463-5224.2007.00515.x

Cited by 63 publications

(99 citation statements)

References 25 publications

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“…This material supports rapid host tissue ingrowth and fosters cellular differentiation, resulting in remodeled tissue that closely resembles the original host tissue [1,[10][11][12]. Similar results have been found for other SIS applications including vascular grafts [13,14], dural replacement, urinary bladder augmentation and urethral reconstruction [15], dermal wounds [16,17], soft tissue augmentation [18], and other uses [19][20][21][22][23][24]. This differentiation may, in part, be related to growth factors found in the SIS [2,25].…”

Section: Introductionsupporting

confidence: 55%

Analgesic Effect of Bupivacaine Eluting Porcine Small Intestinal Submucosa (SIS) in Ferrets Undergoing Acute Abdominal Hernia Defect Surgery

Johnson¹,

Ko²,

Hall³

et al. 2011

Journal of Surgical Research

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Section: Introductionsupporting

confidence: 55%

Analgesic Effect of Bupivacaine Eluting Porcine Small Intestinal Submucosa (SIS) in Ferrets Undergoing Acute Abdominal Hernia Defect Surgery

Johnson¹,

Ko²,

Hall³

et al. 2011

Journal of Surgical Research

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“…Likewise animal derived SIS has been clinically used as a biological material to fill substantial tissue defects [72]. The superior in vivo performance and integrative capacity of this native biological material has inspired many groups in their efforts to create tissue implants on the structural base of native organs.…”

Section: Native Tissue Derived Ecmmentioning

confidence: 99%

Myocardial tissue engineering: the extracellular matrix☆

Akhyari¹,

Kamiya²,

Haverich³

et al. 2008

European Journal of Cardio-Thoracic Surgery

116

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More than a decade after the first reports on successful three-dimensional cardiac cell culture for experimental and potential therapeutic application, the interest and experimental efforts in the field of myocardial tissue engineering continues to grow. The hope that tissue cultures may one day act as graft substitute for malfunctioning myocardium continues to drive current scientific activity. Against this background interest seem to have progressively shifted towards the aim of engineering single tissue components. Accordingly, elements of the extracellular matrix (ECM) have gained increasing attention as potentially crucial mediators in developing and maintaining the characteristics of three-dimensional cardiac cell cultures. The ECM is now no longer regarded as merely a scaffold for developing tissue, a concept that is widely acknowledged in modern tissue engineering. The understanding of the role of precursor and stem cells has highlighted new complicated aspects of cell proliferation and differentiation and ECM proves to play an important role in providing essential signals to influence major intracellular pathways such as proliferation, differentiation and cell metabolism. Furthermore, progress in biochemical engineering has provided the perspective of application of synthetic ECM-linked molecules with bioactive potential. With the advent and continuous refinement of cell removal techniques, a new class of native acellular ECM has emerged with some striking advantages. The presently available ECM materials aim to closely resemble the in vivo microenvironment by acting as an active component of the developing tissue construct. It is therefore not surprising that most of the focus in myocardial tissue engineering has been on cell-matrix interaction, for both naturally derived and synthetic ECM. This article provides a review of established models of myocardial tissue engineering with respect to the employed ECM materials including current frontiers in material development.

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“…Porcine SIS has been used as a graft material in cardiovascular, urological, orthopaedic, neurological, dermatological, reconstructive and ophthalmological applications (Sandusky and others 1992, Badylak and others 1998, Welch and others 2002, Vanore and others 2007, Sheahan and Gillian 2008). It has been used experimentally to reconstruct partial and full‐thickness abdominal body wall defects where it maintained adequate tensile strength and served as a temporary scaffold for host tissue ingrowth.…”

Section: Discussionmentioning

confidence: 99%

The use of porcine small‐intestinal submucosa for abdominal wall reconstruction – a clinical case

Marques

Hipwell

Yool

2009

J of Small Animal Practice

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A seven-year-old miniature dachshund was presented with a large contaminated bite wound centred on the left costal arch. Survey radiographs revealed a pneumomediastinum, a mid-body fracture of the left 11th rib and luxation of the xiphisternum. The compromised skin, ribs, xiphisternum, diaphragm and abdominal wall were surgically debrided. This resulted in a large combined thoracic and abdominal wall defect. The thoracic cavity was closed by diaphragmatic advancement. The abdominal wall defect was partially closed by advancing local abdominal musculature. A cranial abdominal mid-line defect remained and was repaired using two sheets of lyophilised porcine small-intestinal submucosa. Dehiscence of the skin exposing the SIS graft was seen but the abdominal repair remained intact. Eighteen months after the initial injury, the dog remained clinically well and no associated complications were reported.

show abstract

Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats

Cited by 63 publications

References 25 publications

Analgesic Effect of Bupivacaine Eluting Porcine Small Intestinal Submucosa (SIS) in Ferrets Undergoing Acute Abdominal Hernia Defect Surgery

Analgesic Effect of Bupivacaine Eluting Porcine Small Intestinal Submucosa (SIS) in Ferrets Undergoing Acute Abdominal Hernia Defect Surgery

Myocardial tissue engineering: the extracellular matrix☆

The use of porcine small‐intestinal submucosa for abdominal wall reconstruction – a clinical case

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