Surgical resection combined with chemotherapy can help achieve better outcomes in patients with primary colonic lymphoma

Abstract

PCL is a rare malignancy of the gastrointestinal tract, and surgical resection should be considered a part of the standard treatment to achieve a better outcome.

The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis

“…Nonetheless, because that the details of chemotherapy are unavailable from the SEER database, we are incapable to evaluate the actual role of chemotherapy in the treatment of PCL. The present results demonstrated that patients who received surgical intervention exhibited significant survival improvement (113 months versus 74 months, adjusted HR = 0.69, 95% CI: 0.59-0.81) and were consistent with previous study [26], supporting the potential important role of surgery in the comprehensive therapy of PCL.…”

“…Our results demonstrated that patients were diagnosed at the mean age of 63.9 years with a male predominance (male: female = 1.58: 1), which is similar to previous studies in the West and East [10, 12, 18, 26]. Approximately 41.8% and 21.3% of PCL patients were in Ann Arbor stages IE and IVE, respectively, which is similar to the results from a German multicenter trial [27].…”

“…Previous studies that investigated the epidemiological features and survival of PCL were predominantly based on populations from a single institution and case reports; these studies only involved 7-95 patients [8, 10–13, 16, 18–26]. We identified 3342 patients with PCL in the SEER database to identify potential prognostic factors and the role of surgical intervention in PCL management.…”

“…However, the role of surgery in this comprehensive PCL therapy strategy is still subject to debate. Most authors suggest surgery as the optimal initial treatment, regardless of clinical stage, because they believe that surgery provides important prognostic information, prevents complications, and provides the possibility of cure with or without adjuvant therapy [8, 11, 16, 24, 26]. Nevertheless, other investigators argue that NHL is a systemic disease and that surgical cure is unsuitable for advanced gastrointestinal lymphoma.…”

BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation

“…Distant metastasis is the major cause of colon-cancer-related mortality. Although the survival rate of colon cancer patients has improved, the survival of the average patient was less than 20 months [1,2].…”