Surgical resection of metastases to the adrenal gland: a single center experience

Hornstein, I.; Schwarz, Christina; Ebbing, S.; Hoppe‐Lotichius, Maria; Otto, Gerd; Lang, Hauke; Musholt, Thomas J.

doi:10.1007/s00423-015-1293-z

Cited by 14 publications

(12 citation statements)

References 22 publications

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“…Actual 2-year survival in the present material was 43.6%. This is in line with other investigators, who report a 2-year survival rate of 31-40% [24,26]; however, there are studies with better survival reaching 61% at 2 years [9].…”

Section: Discussionsupporting

confidence: 92%

“…The relative prevalence of each primary cancer varies according to the source of data and the geographic region. Data from Asia indicated a high prevalence of stomach (14%), oesophagus (12%) and liver/bile duct cancers (10%) with a paucity of breast cancer and melanoma [4], but even in some European series liver and bile duct cancer may be the most frequent (29%) primary tumour metastasizing to adrenals [24].…”

Section: Discussionmentioning

confidence: 99%

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Adrenal metastases – long-term results of surgical treatment, single-centre experience

Samsel¹,

Cichocki²,

Roszkowska‐Purska³

et al. 2020

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Adrenal metastases – long-term results of surgical treatment, single-centre experience

Samsel¹,

Cichocki²,

Roszkowska‐Purska³

et al. 2020

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“…Primary renal cancer seems to have the best prognosis in comparison to other primary cancers. In 41 patients, overall median survival was 14 months and 5 years survival were observed in 21%, for patients with primary renal, 5 years survival rate was 50% [45]. Significant differences in survival with regard to tumor type were seen in another report, with longer survival for patients with colorectal carcinoma or renal cell carcinoma and shorter for those with non-small lung cancer or melanoma [46].…”

Section: Surgical Treatmentmentioning

confidence: 89%

Adrenal metastases

Samsel¹,

Cichocki²,

Jankowski³

2018

Nowotwory. Journal of Oncology

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The adrenal glands are one of the most prevalent sites for metastases from various malignancies and metastases are indeed the most frequent malignant tumors of the adrenals. The identification of incidental adrenal lesions, of which a high proportion are metastases, have increased since surveillance protocols in cancer treated patients were widely introduced. More sensitive and reliable methods of diagnostic imaging leads to earlier detection of adrenal metastases. If there are no signs and symptoms of disseminated malignant disease, it is essential to differentiate adrenal lesions. CT imaging diagnostics and MRI play the main role in differential diagnosis. Adrenal biopsy is not recommended and is of limited diagnostic value. Appropriate selection of patients with adrenal metastases for curative treatment is a great challenge. Hormonal evaluation should be performed prior to treatment. Adrenalectomy seems to be a reasonable treatment for isolated adrenal metastasis in suitable patients. Minimally invasive laparoscopic adrenalectomy is as effective as the open approach with proven reduction in postoperative pain, morbidity and length of stay. Nonsurgical treatment such as stereotactic body radiation therapy (SBRT), radiotherapy with CyberKnife, percutaneous radiofrequency ablation, percutaneous microwave ablation, radiofrequency plus chemoembolization combined, have been reported with curative and palliative intent and have shown varied results. NOWOTWORY J Oncol 2018; 68, 2: 85-91

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“…1б). Причиной метастатических поражений надпочечни-ков стали злокачественные опухоли печени (n = 12), верхних отделов желудочно-кишечного тракта (n = 5), легких (n = 9), почки (n = 6), нейроэндокринные опу-холи (n = 3), опухоли ободочной кишки (n = 2), яич-ников (n = 2), меланома (n = 2) и опухоли других лока-лизаций (n = 4) [5].…”

Section: диагностика и лечение опухолей мочеполовой системы опухоли unclassified

“…По данным литературы, сред-ний период выживаемости составляет 14 мес, 1-, 2-, 5-, и 10-летняя выживаемость -60, 31, 21 и 11 % со-ответственно [5]. Аналогичные результаты приводятся в обзорной статье R. Paul и соавт.…”

Section: рис 1 выживаемость по методу каплана-майера пациентов с меunclassified

Adrenal metastases: clinical manifestations and surgical outcomes

Латыпов¹,

Попов²,

Латыпова³

et al. 2018

Cancer Urology

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Background. The adrenal glands are one of the most common sites of metastases in malignant disease, particularly lung cancer. The frequency of adrenal metastasis in patients with breast cancer and lung cancer reaches 39 and 35 % respectively.Materials and methods. A total of 156 patients with adrenal tumors underwent surgical treatment in the Siberian State Medical University between December 1998 and July 2017. The study included 16 (10.2 %) patients (9 males and 7 females) with adrenal metastases. The mean age of study participants was 57.6 years (range: 44–73 years).Results. By the moment of surgery, the mean metastatic adrenal tumor size was 4.9 ± 3.0 cm (range: 1.0–10.2 cm). Thirteen out of 16 patients had adrenal metastases from renal cell carcinoma, one patient – from colon cancer, one patient – from lung cancer, and one patient – from breast cancer. Nine patients had left-sided adrenal metastases, whereas six patients had right-sided adrenal metastases. Synchronous adrenal metastasis was detected in two cases: one patient had adrenal metastasis at the side of the renal tumor; the other one had bilateral renal cell carcinoma with both adrenal glands affected.We identified three main variants of the disease course according to prevailing clinical manifestations of adrenal metastasis: no manifestations, pain syndrome, and arterial hypertension.Seven participants had no clinical manifestations; of them, 6 patients had renal cell carcinoma, whereas 1 patient had breast cancer. The mean time between surgical removal of the primary tumor and detection of adrenal metastases was 24.1 months; the mean tumor size was 4.5 cm.Pain syndrome was observed in 5 patients. In three of them, adrenal metastases derived from renal cell carcinoma, in one patient – from lung cancer, and in one patient – from colon cancer. The mean time between removal of the primary tumor and detection of adrenal metastases was 19.8 months; the mean tumor size was 5.4 cm.Arterial hypertension was diagnosed in four patients. The mean time between removal of the primary tumor and identification of adrenal metastases was 27.3 months; the mean tumor size was 4.1 cm. The five-year overall survival rate in operated patient was 47.8 %.Conclusion. Regular examinations of patients after surgical treatment of malignant tumors are needed to detect adrenal metastases; surgery can extend the patient’s life. can extend the patient’s life.

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Surgical resection of metastases to the adrenal gland: a single center experience

Abstract: Resection of adrenal metastases can improve the survival if patients are carefully selected, the tumor is completely resected, and the intervention is integrated into a multidisciplinary oncologic treatment strategy.

Cited by 14 publications

References 22 publications

Adrenal metastases – long-term results of surgical treatment, single-centre experience

Adrenal metastases – long-term results of surgical treatment, single-centre experience

Adrenal metastases

Adrenal metastases: clinical manifestations and surgical outcomes

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