Surgical Resection of Rare Esophageal Cancers

Saddoughi, Sahar A.; Taswell, Jim; Harmsen, William S.; Inra, Matthew L.; Blackmon, Shanda H.; Nichols, Francis C.; Cassivi, Stephen D.; Wigle, Dennis A.; Shen, K. Robert; Allen, Mark S.

doi:10.1016/j.athoracsur.2015.06.015

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…Saddoughi et al performed a retrospective analysis of malignant esophageal cancers including NEC [ 12 ]. They found that 1-year survival after surgical resection for rare types of malignant esophageal cancers was 69%, 5-year survival was 43%, and 10-year survival was 37%.…”

Section: Discussionmentioning

confidence: 99%

Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report

et al. 2018

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BackgroundNeuroendocrine cell carcinoma is a rare variant of esophageal carcinoma. The characteristic clinical features and diagnosis of superficial neuroendocrine cell carcinoma remain to be established. We report a rare case of superficial coexistence of neuroendocrine cell carcinoma with squamous cell carcinoma treated by endoscopic submucosal dissection, and regional lymph node metastasis was detected after additional surgical treatment.Case presentationA 77-year-old Japanese man with esophageal squamous cell carcinoma received endoscopic submucosal dissection in en-bloc resection. Histopathological findings showed that lymphovascular invasion by the neuroendocrine cell carcinoma component occurred in the deep part of the muscularis mucosa. Regional lymph node metastasis was identified after additional surgical treatment. After surgical treatment, our patient received chemotherapy consisting of etoposide and carboplatin for 3 months. He is alive and shows no sign of disease recurrence 12 months after surgery.ConclusionsThis case report highlights the fact that even if neuroendocrine cell carcinoma is small and limited to superficial, the tumor has the potential for metastasis if lymphovascular invasion by the neuroendocrine cell carcinoma component occurs. In addition, this case indicates the necessity of close follow-up of small neuroendocrine cell carcinoma after treatment.

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Section: Discussionmentioning

confidence: 99%

Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report

et al. 2018

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“…In the setting of RTCs, the SEER database (from 2009 to 2013) reports an incidence of 0.22-0.25 cases per 100,000 per year for thymomas, 0.04-0.09 for mediastinal germ-cell tumors, 0.01-5.30 for oesophageal carcinomas, 0.03-0.80 for thoracic sarcomas and 0.30-1.49 for malignant pleural mesothelioma (MPM) [1]. Such a low incidence causes a limited source of data from the literature, with small case series [5][6][7], no prospective studies [8][9][10] and very rare registry studies [11][12][13][14][15] reported. Given their very low frequency, extreme variability of clinical presentation, different treatment options and limited individual expertise, RTCs represent a challenge for most surgeons that could face with troubles in surgical decision making and choice of multimodality strategy.…”

Section: Introductionmentioning

confidence: 99%

Outcome of complex surgical resection and reconstruction for rare thoracic cancers: the clinical value of a predictive score

Pastorino

Leuzzi

Sabia

et al. 2022

Preprint

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BackgroundComplex surgical resection and reconstruction for rare thoracic cancers (RTCs) represent a major challenge, given their very low frequency, extreme variability of presentation, multi-modality treatment options and inadequate outcome prediction. We reported the experience of a tertiary referral centre on a consecutive series of RTC patients, to predict outcome by disease and complexity of surgical procedures.MethodsFrom Jan 2003 to Dec 2018, 1122 surgical procedures were performed with curative intent on 952 RTC patients. Study endpoints were: post-operative hospital stay (Pod), 30-day and 90-day mortality, 5-year and 10-year survival (OS). The follow-up was closed at June 2020.ResultsMedian Pod was 8 days, with a 2% 30-day and 3.9% 90-day mortality. Overall survival (OS) was 85.7% at 1 year, 61.7% at 5 years and 50.7% at 10 years. Ten-year OS was 64.8% in low, 58.8% in intermediate, and 42.4% in high complexity score (Log-rank tests p<0.0001); 64.4% in patients with 1 or 2 reconstructions and 32.8% in patients with 3 or more reconstructions; 44.5% with vascular and 48% with chest wall reconstruction; 71.8% in germ cell tumors and 0% in mesothelioma.ConclusionComplex surgical resection and reconstruction was associated with acceptable 90-day mortality and good 10-year survival in all RTCs but mesothelioma.A predictive score based on surgical complexity and cancer type can help the clinical decision making.

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“…Most esophageal tumors are adenocarcinomas or SCC; however, 0.1% to 4% represent other pathologies. 6,7 A recent study analyzing 4000 esophagectomies identified 24 unusual esophageal malignancies. NETs were identified in 2 patients, none of which were paragangliomas.…”

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confidence: 99%

“…NETs were identified in 2 patients, none of which were paragangliomas. 6 Another study of 830 patients found 15 rare tumors, including 1 neuroendocrine carcinoma. 7 Correct diagnosis of a rare esophageal tumor is challenging.…”

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confidence: 99%

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A Potentially Malignant Giant Esophageal Paraganglioma

Rubinstein

Kouniavsky

et al. 2019

The Annals of Thoracic Surgery

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Paragangliomas are rare NETs that arise from autonomic paraganglia. Approximately 30% to 40% are hereditary, and more than 20 susceptibility genes have been identified. 1,5 Parasympathetic paraganglia give rise to tumors along the branches of the glossopharyngeal and vagus nerves, mostly located in the carotid body and less commonly in the jugulotympanic and vagal paraganglia. Sympathetic paraganglia-derived tumors originate along the sympathetic chain, predominantly in the abdomen. 1 Visceral paragangliomas have been described. 2

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Surgical Resection of Rare Esophageal Cancers

Cited by 10 publications

References 24 publications

Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report

Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report

Outcome of complex surgical resection and reconstruction for rare thoracic cancers: the clinical value of a predictive score

A Potentially Malignant Giant Esophageal Paraganglioma

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