Surgical resection versus radiofrequency ablation for small hepatocellular carcinomas within the Milan criteria

Ueno, S.; Shimada, Masahiko; Kubo, Fumitake; Hiwatashi, Kiyokazu; Tateno, Taro; Baba, Yoshiro; Hasegawa, Susumu; Tsubouchi, Hirohito

doi:10.1007/s00534-009-0069-7

Cited by 113 publications

(84 citation statements)

References 31 publications

(47 reference statements)

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“…Due to the shortage of organ donor and the risk of disease progress on the waiting list, resection was suggested as the first-line treatment to the patients with small HCC and preserved liver function, and could achieve the favorable 5-year OS rate. The 5-year OS rate of resected HCC meeting Milan Criteria, according to the recent reports, ranged from 27% to 80% (Baccarani et al, 2008;Ueno et al, 2009;Lim et al, 2012), even 10-year OS rate in some centers could reach to 56% , and the 5-year RFS rate ranged from 21% to 57% (Ochiai et al, 2004;Lee et al, 2010;Lim et al, 2012). In our study, we observed that the 1-, 3-and 5-year OS rate were 96%, 81% and 76% respectively, and the 1-, 3-and 5-year RFS rate were 68%, 51% and 39% respectively.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Zhu¹,

Huang²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Zhu¹,

Huang²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…RFA and MWA techniques utilise high frequency radio-waves and micro-waves, respectively, to kill tumour tissues by heat. Although several studies have reported better diseasefree survival and a lower frequency of recurrence after surgical resection compared to RFA [10,11] , others report better overall survival and disease-free survival for HCC patients with multi-nodular tumours following RFA [12] . Recently, Simo et al [13] reported no difference regarding the efficacies of MWA and RFA procedures.…”

Section: Hepatocellular Carcinoma and The Unmet Medical Needsmentioning

confidence: 99%

Dickkopfs and Wnt/β-catenin signalling in liver cancer

Fatima¹

2011

WJCO

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Liver cancer is the fifth and seventh most common cause of cancer in men and women, respectively. Wnt/β-catenin signalling has emerged as a critical player in both the development of normal liver as well as an oncogenic driver in hepatocellular carcinoma (HCC). Based on the current understanding, this article summarizes the possible mechanisms for the aberrant activation of this pathway with specific focus on HCC. Furthermore, we will discuss the role of dickkopfs (DKKs) in regulating Wnt/β-catenin signalling, which is poorly understood and understudied. DKKs are a family of secreted proteins that comprise at least four members, namely DKK1-DKK4, which act as inhibitors of Wnt/β-catenin signalling. Nevertheless, not all members antagonize Wnt/β-catenin signalling. Their functional significance in hepatocarcinogenesis remains to be further characterized for which these studies should provide new insights into the regulatory role of DKKs in Wnt/β-catenin signalling in hepatic carcinogenesis. Because of the important oncogenic roles, there are an increasing number of therapeutic molecules targeting β-catenin and the Wnt/ β-catenin pathway for potential therapy of HCC. hepatocellular carcinoma anD the unmet meDical neeDSLiver cancer ranks the fifth most common cancer in men and the second leading cause of cancer-related death. In women, it is the seventh most frequent cancer and sixth leading cause of cancer death [1] . Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver. Men are three times more likely to develop HCC than women and the incidence increases with age [2] . HCC is prevalent in Asia and Africa, but recently it is on the rise in the Western world due to an increase in hepatitis C virus (HCV) infection [3] . Risk factors for HCC include chronic hepatitis B virus (HBV) and HCV infections, cirrhosis, chronic alcohol abuse, aflatoxin ingestion, non-alcoholic steatohepatitis and other metabolic liver diseases [4,5] . Much of HCC occurs in the background of cirrhosis. About 80%-90% of patients with cirrhosis go on to develop HCC eventually and the remaining 10%-20% of cases develop HCC without cirrhosis. Furthermore, HBV and HCV infections increase the risk of developing cirrhosis and later HCC. Among the HCC

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“…The outcome of partial hepatectomy in cirrhotic patients has improved remarkably in recent years with improved surgical techniques and perioperative care (7,8): mortality is reported to range between 0% and 5% in tertiary centers and postoperative hepatic decompensation to be about 4% (8,(20)(21)(22) (20,(24)(25)(26). Regarding transplantability of HCC recurrence, the literature reports that tumor recurrence suitable for salvage transplantation occurs with a median of 60%, ranging from 23% to 89% (20,22,(27)(28)(29)(30).…”

Section: Variables Considered After Hrmentioning

confidence: 99%

Harm and Benefits of Primary Liver Resection and Salvage Transplantation for Hepatocellular Carcinoma

Cucchetti

Vitale

Gaudio

et al. 2010

American Journal of Transplantation

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Primary transplantation offers longer life-expectancy in comparison to hepatic resection (HR) for hepatocellular carcinoma (HCC) followed by salvage transplantation; however, livers not used for primary transplantation can be reallocated to the remaining waiting-list patients, thus, the harm caused to resected patients could be balanced, or outweighed, by the benefit obtained from reallocation of livers originating from HCC patients first being resected. A Markov model was developed to investigate this issue based on literature data or estimated from the United Network for Organ Sharing database. Markov model shows that primary transplantation offers longer life-expectancy in comparison to HR and salvage transplantation if 5-year posttransplant survival remains higher than 60%. The balance between the harm for resected patients and the benefit for the remaining waiting list depends on (a) the proportion of HCC candidates, (b) the percentage shifted to HR and (c) the median expected time-to-transplant. Faced with a low proportion of HCC candidates, the harm caused to resected patients was higher than the benefit that could be obtained for the waiting-list population from re-allocation of extra livers. An increased proportion of HCC candidates and/or an increased median time-to-transplant could lead to a benefit for waiting-list patients that outweighs this harm.

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Surgical resection versus radiofrequency ablation for small hepatocellular carcinomas within the Milan criteria

Cited by 113 publications

References 31 publications

Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Dickkopfs and Wnt/β-catenin signalling in liver cancer

Harm and Benefits of Primary Liver Resection and Salvage Transplantation for Hepatocellular Carcinoma

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