Surgical Revascularization of the Dual Left Anterior Descending Coronary Artery; A Case Report

Chaudhry, Imtiaz A.; Naseer, Mehwish; Fayyaz, Fakhar-e-; Ahmed, Adnan; Javaid, Rehana

doi:10.51253/pafmj.v72isuppl-3.9558

Cited by 1 publication

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“…In contrast, treatment of diabetic rats with clove extract causes higher body weight change due to clove insulin like action on muscle, hepatocytes and adipose tissue. The present results are in agreement with that of Chaudhry et al [31] and Srinivasan et al [32] who reported significant improvement in the glycemic control of diabetic rats that prevented body weight loss and extra intake of food and fluids.…”

Section: Discussionsupporting

confidence: 94%

The Influence of Syzygium aromaticum Ethanolic Extract Against Streptozotocin-Induced Diabetic Rats

Hussien,

Fyiad,

Ali

et al. 2023

Egypt. J. Chem.

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Diabetes Mellitus (DM) is characterized by hyperglycemia and increased level of reactive oxygen species (ROS). Our study verified Syzygium aromaticum (clove) ethanolic extract phytochemical composition by high-performance liquid chromatography (HPLC) analysis to assess clove extract possible impact on glucose status, liver and kidney functions, and oxidative stress in diabetic model. Dry Syzygium aromaticum buds obtained from the market, grinded, extracted by 70% ethanol. Thirty two adult male rats were classified into four groups (8per each). Controls (CG), Syzygium aromaticum group (SAG): rats received (500 mg/kg b.wt.) clove ethanolic extract, Diabetic rats (DG): injected with Streptozotocin [STZ, 75 mg/kg b.wt. (a single dose)], intraperitoneally (IP). Diabetic treated group (DSA): rats injected with STZ as in (DG) group and at the eighth day rats were treated with the ethanolic extract of clove as in (SAG) group. Animals were sacrificed after 14 days. Glucose level, liver enzymes, amylase activity, kidney function tests, total antioxidant capacity (TAC), malondialdehyde (MDA), albumin and total protein (TP) levels were measured. Also, the body weights of each rat were determined throughout the experimental period. Administration of STZ increased glucose level, hepatic markers, urea, creatinine, and MDA levels. Conversely, serum TAC, albumin, TP and α-amylase activity were significantly decreased. All the aforementioned parameters were improved due to the treatment of diabetic rats with clove ethanolic extract. Clove extract could be a promising therapeutic agent in the treatment of diabetic models.

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Section: Discussionsupporting

confidence: 94%