Surgical Risk Factors in Primary Surgery for Localized Neuroblastoma: The LNESG1 Study of the European International Society of Pediatric Oncology Neuroblastoma Group

Cecchetto, Giovanni; Mosseri, Véronique; Bernardi, Bruno; Helardot, P. G.; Monclair, Tom; Costa, É.; Horcher, Ernst; Neuenschwander, S.; Tomà, Paolo; Rizzo, A; Michon, Jean; Holmes, Keith

doi:10.1200/jco.2005.02.4661

Cited by 195 publications

(158 citation statements)

References 24 publications

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“…INSS stage, tumour site, progression/relapses and deaths were recorded. OC, biochemical, histological and biological analyses were as previously described [5,6].…”

Section: Methodsmentioning

confidence: 99%

“…From Cecchetto et al [5] we know that 17% of the patients with IDRF (Stage L2) suffered OC, as opposed to five percent in patients without IDRF (Stage L1) (P < 0.0001). Other data from Cecchetto et al is not repeated herein.…”

Section: Survival Related To Operative Complications and Treatment Grmentioning

confidence: 99%

“…The concept of surgical risk factors in neuroblastoma surgery was introduced with the LNESG1 study, and in 2005 Cecchetto et al described the short-term adverse effects of the risk factors [5]. Since then survival in LNESG1 related to INSS have been reported [6].…”

Section: Introductionmentioning

confidence: 99%

“…In 2005 the International Neuroblastoma Risk Group (INRG) Task Force, representing all major co-operative paediatric cancer groups, adopted the principle of surgical risk factors and incorporated it in the INRG Staging System [7,8]. The INRG Task Force preferred the term Image-Defined Risk Factors (IDRF) to surgical risk factors, and agreed upon a list of IDRF that was similar to the list used in this study (Table I) [5,7,8]. In the INRG system the two stages of localised neuroblastoma, L1 and L2, are defined by the absence of IDRF (Stage L1) or by the presence of one or more IDRF (Stage L2) [7].…”

Section: Introductionmentioning

confidence: 99%

“…The absence of IDRF (Stage L1) would predict a low risk of OC and a high possibility of complete tumour excision [5]. In the presence of IDRF (Stage L2) the protocol advised against primary surgery.…”

Section: Introductionmentioning

confidence: 99%

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Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Monclair

Mosseri

Cecchetto

et al. 2015

Pediatric Blood & Cancer

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BackgroundThe European multicenter study LNESG1 was designed to evaluate the safety and efficacy of surgical treatment alone in patients with localised neuroblastoma. In a retrospective, observational study we examined the impact of image‐defined risk factors (IDRF) on operative complications and survival (EFS and OS).Procedure534 patients with localised, non‐MYCN amplified neuroblastoma were recruited between 1995 and 1999. Group 1 consisted of 291 patients without IDRF (Stage L1 in the International Neuroblastoma Risk Group (INRG) staging system), all treated with primary surgery. Group 2: 118 patients with IDRF (INRG Stage L2), also treated with primary surgery. Group 3: 125 patients in whom primary surgery was not attempted, 106 receiving neo‐adjuvant chemotherapy.ResultsIn L1 patients (Group 1) 5‐year EFS was 92% and OS 98%. In L2 patients (Group 2 and 3) EFS was 79% and OS 89%. The differences in both EFS and OS were significant. EFS and OS in Group 2 (86% and 95%) were significantly better than 73% and 83% in Group 3. In INSS stage 1, 2 and 3, EFS were respectively 94%, 81% and 76%. Except between stage 2 and 3 the differences were significant. OS were respectively 99%, 93% and 83%, all significantly different. The 17% operative complication rate in L2 patients was significantly higher than 5% in L1 patients.ConclusionsIn localised neuroblastoma, IDRF at diagnosis are associated with worse survival rates and higher rates of operative complications. The impact of IDRF should become an integrated part of therapy planning. Pediatr Blood Cancer 2015;62:1536–1542. © 2015 Wiley Periodicals, Inc.

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“…INSS stage, tumour site, progression/relapses and deaths were recorded. OC, biochemical, histological and biological analyses were as previously described [5,6].…”

Section: Methodsmentioning

confidence: 99%

Section: Survival Related To Operative Complications and Treatment Grmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Monclair

Mosseri

Cecchetto

et al. 2015

Pediatric Blood & Cancer

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Neuroblastoma

Vaidya¹,

Pearson²

2010

Pediatric Hematology and Oncology

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Investigation of YAP‐1, OTX‐2, and nestin protein expressions in neuroblastoma: a preliminary study

Kum Özşengezer,

Altun,

Sanlav

et al. 2024

Ann Clin Transl Neurol

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ObjectivesNeuroblastoma is the most common extracranial solid tumor in childhood. YAP (Yes‐associated protein) is a highly expressed protein in NB. Nestin is an important marker of neuronal differentiation in NB. Orthodenticle homeobox (OTX) is a transcription factor and is overexpressed in blastoma‐derived tumors. The aim of this study was to examine the potential roles of YAP‐1, Nestin, and OTX‐2 proteins in prognosis and risk stratification in neuroblastomaMethodsTumor sections of 56 patients with different NB risk groups were analyzed. YAP‐1, Nestin, and OTX‐2 protein expression levels were evaluated by immunohistochemical staining in NB patient tissue samples.ResultsYAP‐1, Nestin, and OTX‐2 protein expression levels were evaluated together with the clinical findings of NB patients. YAP‐1 was expressed in 18% of all tissues, while Nestin was expressed in 20.4%. OTX‐2 protein expression was found in 41.1% of the NB patients. YAP‐1 was expressed in 26.9% of high‐risk and 11.5% of low‐risk patients. Nestin was expressed in 24.4% high‐risk and 33.3% low‐risk patients. OTX‐2 was expressed in 68.2% high‐risk and 60% low‐risk patients.YAP‐1 was shown to provide survival advantages among risk groups.InterpretationThe findings of this study support that YAP‐1 may be a potential prognostic biomarker for staging and risk‐group assignment of NB patients. YAP‐1 expression in neuroblastoma is associated with significantly poorer survival probabilities and should be considered as a potential therapeutic target. OTX‐2 is a promising predictive biomarker candidate, but its mechanisms need further investigation in neuroblastoma, as nestin expression is not significantly linked to patient survival.

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Surgical Risk Factors in Primary Surgery for Localized Neuroblastoma: The LNESG1 Study of the European International Society of Pediatric Oncology Neuroblastoma Group

Cited by 195 publications

References 24 publications

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Neuroblastoma

Investigation of YAP‐1, OTX‐2, and nestin protein expressions in neuroblastoma: a preliminary study

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