Surgical site infection following open lobectomy in patients with lung cancer: A prospective study

Abstract

Objective To assess the incidence and risk factors of surgical site infection after open pulmonary lobectomy and to quantify their clinical and economic burden. Methods A prospective nested case‐control study was performed on patients with lung cancer who underwent open lobectomy in the lung cancer center of West China Hospital from January 2017 to December 2019. Demographic, clinical data and medical costs were recorded. Logistic regression was used to evaluate risk factors associated with surgical site infection. A Mann‐Whitney U test was carried out to evaluate the differences in medical costs. Results A total of 1395 patients were eligible, and the surgical site infection incidence was 13.47% (188/1395). Of the 188 instances of surgical site infection, 171 (90.96%) were classified as organ/space infection, 8 (4.25%) as superficial incisional infection and 9 (4.79%) as deep incisional infection. The patients with surgical site infection had significantly higher mortality (3.19% vs. 0.41%, p < 0.001), higher median medical cost (90774.95 yuan vs. 63079.38 yuan, p < 0.001), and longer postoperative length of stay (15 days vs. 9 days, p < 0.001). Multivariate logistic regression analysis indicated that age (odds ratio (OR) = 1.560, p = 0.007), respiratory failure (OR = 5.984, p = 0.0012), American Society of Anesthesiologists score (OR = 1.584, p = 0.005), operating time (OR = 1.950, p < 0.001), and operation team (OR = 1.864, p < 0.001) were independent risk factors for surgical site infection. Conclusions The high incidence of surgical site infection indicates that postoperative infections remain a significant clinical burden in patients who underwent open lobectomy. Identifying risk factors timely through prospective surveillance may assist clinical decisions against surgical site infection.

Comprehensive analysis of risk factors for surgical site infections following thoracoscopic radical resection in patients with lung cancer

“…SSIs complicate the postoperative course by extending hospital stays, necessitating additional treatments and, significantly, escalating healthcare costs. 11 …”

“…Notwithstanding these advancements, SSIs continue to present as a substantial postoperative complication, adversely affecting both the short‐term and long‐term prognosis. SSIs complicate the postoperative course by extending hospital stays, necessitating additional treatments and, significantly, escalating healthcare costs 11 …”

“…SSIs complicate the postoperative course by extending hospital stays, necessitating additional treatments and, significantly, escalating healthcare costs. 11 The ramifications of SSIs are not limited to mere physical afflictions. Patients and their families often undergo significant psychological stress, manifesting in forms of heightened anxiety and depressive states.…”