Surgical-site infection with toxin A-nonproducing and toxin B-producing Clostridium difficile

Kikkawa, Hiromi; Miyamoto, Kazunori; Takiguchi, Noriaki; Kondo, Tsukasa; Hitomi, Shigemi

doi:10.1007/s10156-007-0568-x

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…The clinical outcome for our patient after the administration of intravenous, then oral metronidazole was positive, similarly to a case report of surgical site infection described by Kikkawa et al (2008) where only oral metronidazole was administered (Kikkawa et al 2008). In contrast to our observation, Urbán et al (2010) found empirical treatment by metronidazole combined with cefazolin to be ineffective, and this therapy changed to imipenem/cilastatin on the basis of antibiotic susceptibility (Urbán et al 2010).…”

Section: Discussionsupporting

confidence: 76%

“…The standards for treating soft tissue infection caused by C. difficile have not been determined (Kikkawa et al 2008). The clinical outcome for our patient after the administration of intravenous, then oral metronidazole was positive, similarly to a case report of surgical site infection described by Kikkawa et al (2008) where only oral metronidazole was administered (Kikkawa et al 2008).…”

Section: Discussionsupporting

confidence: 68%

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Clostridium difficile ribotype 078 cultured from post-surgical non-healing wound in a patient carrying ribotype 014 in the intestinal tract

et al. 2015

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Extra-intestinal infections caused by Clostridium difficile are rare. The risk of extra-intestinal infections associated with C. difficile may be particularly relevant in environments contaminated with C. difficile spores. This paper describes the case of a non-diarrheic patient colonized with C. difficile ribotype 014 in the intestinal tract who developed a post-surgical wound infection by C. difficile ribotype 078. The infection responded to metronidazole administered first intravenously and then orally. This case indicates that C. difficile may not only be related to diarrheic diseases, but also to infections of non-healing wounds, especially in situations when C. difficile is the only isolated pathogen.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 68%

Clostridium difficile ribotype 078 cultured from post-surgical non-healing wound in a patient carrying ribotype 014 in the intestinal tract

et al. 2015

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“…Although some authors have described cases of extraintestinal C. difficile infections, only in a few cases were these bacilli isolated in monoculture: a case of pleural empyema (Simpson et al, 1996), bacteraemia and iliac muscle abscess (Bedimo & Weinstein, 2003), brain empyema (Gravisse et al, 2003) and surgical site infection (Kikkawa et al, 2008). Garcia-Lechuz et al (2001) reviewed 21 cases of extraintestinal C. difficile infections and only in one case were these bacilli isolated as a single pathogen.…”

Section: Discussionmentioning

confidence: 99%

“…There are no standards for the treatment of soft-tissue C. difficile infections (Kikkawa et al, 2008). C. difficile strains resistant to metronidazole and ciprofloxacin have also been described (Peláez et al, 2008;Spigaglia et al, 2008), so only a guided antimicrobial therapy based on reliable microbiological investigations seems to be the procedure of choice in this kind of infection.…”

Section: Discussionmentioning

confidence: 99%

Toxin A-producing Clostridium difficile as an aetiological factor of post-traumatic wound infection

Deptuła

Kruszyńska

Mikucka

et al. 2009

Journal of Medical Microbiology

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Clostridium difficile is a well-known cause of hospital-acquired infection such as antibiotic associated diarrhoea or pseudomembranous colitis. Extraintestinal infections caused by this pathogen are described rarely. A case of post-traumatic wound infection caused by C. difficile in an immunocompetent, young and otherwise healthy trauma patient is reported. A 31-year-old female, a car accident victim, was admitted to hospital because of polytrauma. After open reduction and internal fixation of a supracondylar femoral fracture by means of the dynamic condylar screw (DCS) system, a purulent fistula occurred. Microbiological examination of the pus revealed C. difficile as the single aetiological factor of this infection. Empirical antibiotic treatment with cefazoline and metronidazole had been administered right after the surgery, but was found to be ineffective. The strain isolated from the patient was sensitive to most antimicrobials except for clindamycin, and amoxicillin/clavulanic acid was chosen for the guided therapy. Such treatment combined with the removal of the DCS system produced a desirable effect.

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Extraintestinal Clostridium difficile Infections

Mattila

Arkkila²,

Mattila³

et al. 2013

Clinical Infectious Diseases

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Extraintestinal CDIs occur mainly in hospitalized patients with significant comorbidities. Extraintestinal CDIs in the abdominal area may result from either intestinal perforation after infection or after intestinal surgery. Wound infections may result from colonization by feces. Clostridium difficile may reach distant sites via bacteremia. Mortality in extraintestinal CDIs is associated with the severity of underlying diseases.

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Surgical-site infection with toxin A-nonproducing and toxin B-producing Clostridium difficile

Cited by 4 publications

References 20 publications

Clostridium difficile ribotype 078 cultured from post-surgical non-healing wound in a patient carrying ribotype 014 in the intestinal tract

Clostridium difficile ribotype 078 cultured from post-surgical non-healing wound in a patient carrying ribotype 014 in the intestinal tract

Toxin A-producing Clostridium difficile as an aetiological factor of post-traumatic wound infection

Extraintestinal Clostridium difficile Infections

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