Surgical site infections after abdominal surgery: incidence and risk factors. A prospective cohort study

Aga, Emil; Keinan‐Boker, Lital; Eithan, Arieh; Mais, Tamar; Rabinovich, A. S.; Nassar, Faris

doi:10.3109/23744235.2015.1055587

Cited by 95 publications

(94 citation statements)

References 24 publications

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“…P. aeruginosa were 100 % resistant to oxacillin, ceftibuten, tetracycline, and erythromycin. This is comparable with the rates reported by various authors [5,6,10,[25][26][27][28][29][30][31][32][33]. Thus, the investigation demonstrated that in the Ukrainian surgery hospitals the incidence rate of SSIs causal agents resistant to antimicrobial medicines is quite high.…”

Section: Discussionsupporting

confidence: 80%

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Incidence of Surgical Site Infections (SSIs) and Antimicrobial Resistance their Pathogens in Ukraine

Salmanov¹,

Vdovychenko²,

Nychytailo³

et al. 2018

Inter. jour. antoboit. and probiot.

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OBJECTIVE -to analyses the results of patients' surgery, to determine the incidence rate of surgical site infections (SSIs) and to identify prevailing pathogens and their resistance to antibiotics in Ukrainian hospitals. MATERIALS AND METHODS.The investigation included 9,408 patients who underwent surgeries during 2015 in 12 surgical hospitals in different Ukrainian regions. In order to determine the incidence rates of SSIs were used the standard definition that were developed by the CDС (USA). The investigation included the analysis of 1,248 strains from patients with clinical symptoms SSIs. The identification and antimicrobial susceptibility of cultures were determined, using automated microbiology analyzer Vitek 2 Compact (BioMerieux, France). Susceptibility to antibiotics was determined using AST cards (BioMerieux, France). Some antimicrobial susceptibility test used Kirby -Bauer antibiotic testing. Interpretative criteria were those suggested by the CLSI (USA). RESULTS AND DISCUSSION. Data analysis demonstrated that 13.3 % (CI 95 %: 12.3-14.2 %) patients developed postoperative SSIs. Infection rates after various surgical procedures at surgical sites were observed. Shows the high infection rate in appendectomy (17.47 %), gastric, small and large bowel surgeries (18.23 %). The infection rate in orthopedic procedures (13.27 %), cholelithiasis (hepatobiliary) (14.93 %), uterus and adnexal structures (11.10 %), urinary tract and genitalia (9.37 %) and hernia (14.1 %) are comparatively lower. The infection rate in lower segment caesarean structure is 4.24 % and excision of dermoid cysts, lipomas 3.22 %. Staphylococcus aureus was identified as the most common causative agent of SSIs (27.6 %), followed by Escherichia coli (14.1 %), Enterococcus faecalis (13.5 %), and Pseudomonas aeruginosa (10.1 %). Frequency of Klebsiella pneumoniae, Acinetobacter baumannii, Enterobacter aerogenes, Enterococcus faecium, Streptococcus spp., Staphylococcus epidermidis and Proteus vulgaris was 7.1 %, 6.9 %, 6.1 %, 4.7 %, 4.6 %, 3.6 %, and 1.6 %, respectively. Antibiotic susceptibility testing showed that all strains of S. aureus resistant to penicillin. The most active antibiotics found were linezolid, tigecycline, and mupirocin, showing growth inhibition of 100 % strains tested, followed by nitrofurantoin, trimethoprim/ sulphamethoxazole, to fusidic acid, teicoplanin, fosfomycin, gentamycin, vancomycin. Susceptibility to tetracycline, rifampicin, erythromycin, and clindamycin was observed to be some lower. Methicillin-resistant S. aureus comprised 29.1 %, while Vancomycin-resistant S. aureus comprised 9.3 %. Resistance E. faecalis to ceftibuten, chloramphenicol, moxifloxacin, and teicoplanin was 100 % and to cefepime 96 %. The proportion of vancomycin-resistant enterococci was 6.9 %. 26.5 % of E. coli strains showed resistance to all tested antibiotics. The most potent antimicrobials were imipenem, tobramycin, meropenem, levofloxacin and amikacinum. The high rates of resistance were found to penicillum, lincomycin, clindamy...

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Section: Discussionsupporting

confidence: 80%

“…The distribution of various groups of microorganisms varies considerably [5][6][7][8][9][10][25][26][27][28][29]. This proves the necessity of carrying out microbiological monitoring in every surgery hospital.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Surgical Site Infections (SSIs) and Antimicrobial Resistance their Pathogens in Ukraine

Salmanov¹,

Vdovychenko²,

Nychytailo³

et al. 2018

Inter. jour. antoboit. and probiot.

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“…Additionally, studies have shown that cigarette smokers have increased cardiovascular disease 23 and a higher risk of recurrent myocardial infarction 24,25 . Studies in colorectal and abdominal surgery indicate that patients with congestive heart failure have a higher risk of developing surgical site infections 26,27 . Thus, we performed a series of stacked multiple regressions to adjust the weighted effect of smoking status, packs per decade, and comorbidities, given the potential for colinearity among confounding variables.…”

Section: Discussionmentioning

confidence: 99%

Smoking Increases the Rate of Reoperation for Infection within 90 Days After Primary Total Joint Arthroplasty

Tischler

Chen

et al. 2017

The Journal of Bone and Joint Surgery

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“…This study also found that diabetes mellitus, smoking, operations lasting more than 3 hours, the absence of antibiotic prophylaxis, and a history of previous surgery were positive risk factors associated with a significant upsurge in SSIs. 87 SSIs comprise at least 14%-22.2% of all HCAIs for abdominal surgery [88][89][90] and often lead to extended hospitalization and higher antimicrobial costs. 71 The microorganisms generally involved in such SSIs include S. aureus, coagulasenegative Staphylococci and Enterococcus spp., and E. coli.…”

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confidence: 99%

Health care-associated infections – an overview

Haque¹,

Sartelli²,

McKimm³

et al. 2018

IDR

970

610

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Health care-associated infections (HCAIs) are infections that occur while receiving health care, developed in a hospital or other health care facility that first appear 48 hours or more after hospital admission, or within 30 days after having received health care. Multiple studies indicate that the common types of adverse events affecting hospitalized patients are adverse drug events, HCAIs, and surgical complications. The US Center for Disease Control and Prevention identifies that nearly 1.7 million hospitalized patients annually acquire HCAIs while being treated for other health issues and that more than 98,000 patients (one in 17) die due to these. Several studies suggest that simple infection-control procedures such as cleaning hands with an alcohol-based hand rub can help prevent HCAIs and save lives, reduce morbidity, and minimize health care costs. Routine educational interventions for health care professionals can help change their hand-washing practices to prevent the spread of infection. In support of this, the WHO has produced guidelines to promote hand-washing practices among member countries.

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Surgical site infections after abdominal surgery: incidence and risk factors. A prospective cohort study

Abstract: The significant risk factors defined should be addressed preoperatively to decrease the risk for SSI. Wound surveillance in the post-discharge period is necessary for correct estimation of SSI rates.

Cited by 95 publications

References 24 publications

Incidence of Surgical Site Infections (SSIs) and Antimicrobial Resistance their Pathogens in Ukraine

Incidence of Surgical Site Infections (SSIs) and Antimicrobial Resistance their Pathogens in Ukraine

Smoking Increases the Rate of Reoperation for Infection within 90 Days After Primary Total Joint Arthroplasty

Health care-associated infections – an overview

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Surgical site infections after abdominal surgery: incidence and risk factors. A prospective cohort study

Abstract: The significant risk factors defined should be addressed preoperatively to decrease the risk for SSI. Wound surveillance in the post-discharge period is necessary for correct estimation of SSI rates.

Cited by 95 publications

References 24 publications

Incidence of Surgical Site Infections (SSIs) and Antimicrobial Resistance their Pathogens in Ukraine

Incidence of Surgical Site Infections (SSIs) and Antimicrobial Resistance their Pathogens in Ukraine

Smoking Increases the Rate of Reoperation for Infection within 90 Days After Primary Total Joint Arthroplasty

Health care-associated infections &ndash; an overview

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Health care-associated infections – an overview