Illicit injection of different, exogenous substances into the penis for enlargement purposes is a practice that is still met in some of the Eastern countries of Europe. Our study conducted over a period of 3 years (2016-2019) at the Urology Clinic from Tirgu Mures,highlights the complications that can occurre after the injection of different chemical substances, such as liquid paraffin, vaseline, olive oil etc., into the penile subcutaneous tissue with the purpose of augmentation. We report 7 patients presenting several complications some of them severe such as: extensive fibrosis, ulceration, penile deformity, erectile dysfunctions, requiring different surgical procedures. The surgical technique was selected according to the extension of fibrosis or necrosis:excision of the necrotic, fibrotic tissue, scrotal skin flap reconstruction etc. In our study, we found 7 patients that accomplished the inclusion criteria. Five patients were diagnosed with penile fibrosis after self-injection of Kanamycin, and two of the patients had the same diagnosis after self-injection of Vaseline. In 2 patients, the postoperative outcome was complicated by wound dehiscence and necrosis, requiring other reconstructive surgeries, and in 5 patients postoperative recovery was a favorable one, without significant complications. In the management of complications of illicit injection of different, exogenous substances into the penis, penile tunneling with scrotal flap technique seems to offer good results due to the vascular flap, allowing faster wound healing and a superior aesthetic and functional result.