Surgical strategies for chronic pancreatitis in a 1,327- patient Scandinavian Baltic pancreatic Club (SBPC) register

Parhiala, Mikael; Waage, Anne; Ignatavičius, Povilas; Olesen, Søren Schou; Poulsen, Jakob Lykke; Engjom, Trond; Nordaas, Ingrid Kvåle; Hadi, Ainul; Kalaitzakis, Evangelos; Drewes, Asbjørn Mohr; Nøjgaard, Camilla; Laukkarinen, Johanna

doi:10.1016/j.pan.2022.12.004

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…Patients with EP and later pancreatic surgery (23%) had worse outcomes on all EORTC C‐30 parameters, but only pain, fatigue and financial difficulties were statistically significant. In our earlier study CP patients who underwent surgery for CP related pain had better outcomes if they did not have prior EP 27 . This could be due to delayed surgery because of prior endoscopic procedures.…”

Section: Discussionmentioning

confidence: 86%

“…The reference population here consisted of 382 (44%) patients who completed the EORTC QLQ‐C30 questionnaire a median of two 1–39 years after their diagnosis. The two groups did not differ in age, sex, alcohol or by aetiology but the reference population had a shorter disease duration ( p < 0.001) and more smoking ( p = 0.029).…”

Section: Resultsmentioning

confidence: 99%

“…The reference population here consisted of 382 (44%) patients who completed the EORTC QLQ‐C30 questionnaire a median of two 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 years after their diagnosis. The two groups did not differ in age, sex, alcohol or by aetiology but the reference population had a shorter disease duration ( p < 0.001) and more smoking ( p = 0.029).…”

Section: Resultsmentioning

confidence: 99%

“…In our earlier study CP patients who underwent surgery for CP related pain had better outcomes if they did not have prior EP. 27 This could be due to delayed surgery because of prior endoscopic procedures.…”

Section: Quality Of Lifementioning

confidence: 99%

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Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study

Parhiala,

Nøjgaard,

Bartholdy

et al. 2023

UEG Journal

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BackgroundChronic Pancreatitis (CP) causes morphological changes in the pancreatic tissue, leading to complications and pain, which may require endoscopic interventions.ObjectiveOur aim was to determine the frequency of endoscopic procedures (EP) in CP patients and to analyse pain and quality of life (QoL) in these patients after their EP.MethodsThis study included 1327 CP patients from the Scandinavian Baltic Pancreatic Club (SBPC) database including four countries and eight centres. We analysed patients undergoing EPs and gathered information on the EP, pancreatic function, pain, disease and duration. The EORTC C‐30 QoL questionnaire was gathered prospectively and multivariable analysis was conducted on independent parameters between the groups. The reference population had no interventions (n = 870).Results260 CP patients (22%) underwent EPs, median one year (range 0–39 years) after CP diagnosis. 68% were males. The median age was 59 (20–90) years. Most common aetiological factors were alcohol in 65% and smoking in 71%. Extracorporeal shock wave lithotripsy (ESWL) was used in 6% of the CP population and in 21% of the EP group. Biliary duct stenting was performed on 37% and pancreatic stenting was performed on 56% of the patients. There was no difference in pain patterns between patients who had pancreatic stenting and the reference population. The EP group had slightly better QoL (p = 0.047), functioning and fewer symptoms than the reference population, in the multivariable analysis there was no interaction effect analysis between the groups. The pancreatic stent group had better QoL and the same amount of pain than the reference group. The patients who needed later surgery (23%) had more pain (p = 0.043) and fatigue (p = 0.021).ConclusionsOne in five of the CP patients underwent EP. These patients scored higher on QoL responses and had better symptom scores. CP patients who had pancreatic stenting performed had the same pain patterns as the reference population. Randomised prospective trials are needed to determine the effect of endoscopy procedures on CP patients.

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Section: Discussionmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Quality Of Lifementioning

confidence: 99%

See 2 more Smart Citations

Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study

Parhiala,

Nøjgaard,

Bartholdy

et al. 2023

UEG Journal

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“…The data from the Scandinavian Baltic Pancreatic Club database showed that only 7% of the patients with CP underwent pancreatic surgery; pain (54%) was the most common indication, and most patients underwent endoscopic procedures before surgery. 114 To date, the widely accepted concept is that surgery is more effective, while endoscopy is minimally invasive and considered as the first-line treatment.…”

Section: Endoscopy Versus Surgerymentioning

confidence: 99%

Management of chronic pancreatitis: recent advances and future prospects

Han,

Lv,

2024

Therap Adv Gastroenterol

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As a progressive fibroinflammatory disease, chronic pancreatitis (CP) often manifests as recurrent bouts of abdominal pain with or without complications, causing a heavy burden of health care. In recent years, some meaningful insights into the management of CP have been obtained from randomized controlled trials, systematic reviews, and meta-analyses, which were of great importance. Based on this research, it is shown that there are various treatments for CP. Therefore, it is of great importance to choose a suitable strategy for patients with CP individually. Relevant evidence on the management of CP was summarized in this review, including nutrition supplements, medication, endoscopy, surgery, exploration of novel therapies as well as evaluation and prediction of treatment response.

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Ketamine infusion for pain management in hospitalized patients with Chronic Pancreatitis: A case series

et al. 2023

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Surgical strategies for chronic pancreatitis in a 1,327- patient Scandinavian Baltic pancreatic Club (SBPC) register

Cited by 3 publications

References 35 publications

Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study

Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study

Management of chronic pancreatitis: recent advances and future prospects

Ketamine infusion for pain management in hospitalized patients with Chronic Pancreatitis: A case series

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