Surgical Therapy for Small-Bowel Carcinoid Tumors

Strodel, William E.; Talpos, Gary B.; Eckhäuser, Frederic E.; Thompson, Norman W.

doi:10.1001/archsurg.1983.01390040003001

Cited by 107 publications

(54 citation statements)

References 33 publications

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“…Acute or chronic ileus, seen in 12 patients, was somewhat less infrequent than reported in other series (23). More common was entrapment of the intestine with partial obstruction or localized edema of the intestinal wall.…”

Section: Operative Findings and Surgical Strategymentioning

confidence: 60%

Abdominal Surgery in Patients with Midgut Carcinoid Tumors

1991

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Section: Operative Findings and Surgical Strategymentioning

confidence: 60%

Abdominal Surgery in Patients with Midgut Carcinoid Tumors

1991

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“…Multiple lesions may be found in up to 40% of cases [4] . Clinical manifestations include abdominal pain, bowel obstruction, diarrhea, weight loss and bleeding [15] . The prognosis of these NETs is generally unfavorable when compared with other location tumors of comparable size since they have a higher tendency to grow and spread before the diagnosis is firmed [14,15] .…”

Section: Most Duodenal Netsmentioning

confidence: 99%

“…Clinical manifestations include abdominal pain, bowel obstruction, diarrhea, weight loss and bleeding [15] . The prognosis of these NETs is generally unfavorable when compared with other location tumors of comparable size since they have a higher tendency to grow and spread before the diagnosis is firmed [14,15] . The 5year survival correlates with the stage of disease at diagnosis, being of 65% for patients with localized disease and only 36% for those with distant metastases [5] .…”

Section: Most Duodenal Netsmentioning

confidence: 99%

Small bowel neuroendocrine tumors: From pathophysiology to clinical approach

Xavier

Rosa

Cotter

2016

WJGP

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Author contributions: Xavier S performed the literature search, designed the text structure and wrote the text; Rosa B and Cotter J suggested the theme to be reviewed, and made the several critical corrections and revisions, including English editing, until the submitted version was achieved.Conflict-of-interest statement: All the authors hereby declare that they do not have any conflict-of-interest (including but not limited to commercial, personal, political, intellectual, or religious interests) related to the work submitted herein. AbstractNeuroendocrine tumors (NETs), defined as epithelial tumors with predominant neuroendocrine differentiation, are among the most frequent types of small bowel neoplasm. They represent a rare, slow-growing neoplasm with some characteristics common to all forms and others attributable to the organ of origin. The diagnosis of this subgroup of neoplasia is not usually straight-forward for several reasons. Being a rare form of neoplasm they are frequently not readily considered in the differential diagnosis. Also, clinical manifestations are nonspecific lending the clinician no clue that points directly to this entity. However, the annual incidence of NETs has risen in the last years to 40 to 50 cases per million probably not due to a real increase in incidence but rather due to better diagnostic tools that have become progressively available. Being a rare malignancy, investigation regarding its pathophysiology and efforts toward better understanding and classification of these tumors has been limited until recently. Clinical societies dedicated to this matter are emerging (NANETS, ENETS and UKINETS) and several guidelines were published in an effort to standardize the nomenclature, grading and staging systems as well as diagnosis and management of NETs. Also, some investigation on the genetic behavior of small bowel NETs has been recently released, shedding some light on the pathophysiology of these tumors, and pointing some new directions on the possible treating options. In this review we focus on the current status of the overall knowledge about small bowel NETs, focusing on recent breakthroughs and its potential application on clinical practice.

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“…Типичным клиничес ким признаком является дискомфорт в жи воте, ошибочно трактуемый как синдром раздраженной кишки. Перитуморальный фиброз может привести к кишечной непро ходимости [10]. У некоторых пациентов из за чрезмерно быстрой бактериальной диссеминации развивается несекреторная диарея.…”

Section: клиническая картина нефункционирующие опухолиunclassified

“…В сравнении с другими гастроэнтеропа нкреатическими нейроэндокринными опухо лями у опухолей подвздошной/тощей кишки прогноз неблагоприятен в связи с тенденци ей метастазировать в печень, минуя регио нарные лимфоузлы [3,10]. Выживаемость коррелирует со стадией болезни: 5 летняя выживаемость составляет 65% при местном процессе и отсутствии отдаленных метаста зов и 36% при наличии отдаленных метаста зов [1,3,10,12].…”

Section: прогнозunclassified

Management of patients with differentiated neuroendocrine tumors of jejunum and ileum (according to international guidelines)

Бельцевич¹,

Мельниченко²

2011

Endocrine Surgery

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Д.Г. Бельцевич, Г.А. Мельниченко ФГБУ Эндокринологический научный центр Минздравсоцразвития РФ, МоскваБельцевич Д.Г. -доктор мед. наук, главный научный сотрудник отдела хирургии эндокринных органов ФГБУ Эндокринологический научный центр Минздравсоцразвития РФ; Мельниченко Г.А. -доктор мед. наук, профес сор, член корр. РАМН, директор Института клинической эндокринологии ФГБУ Эндокринологический научный центр Минздравсоцразвития РФ.

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Surgical Therapy for Small-Bowel Carcinoid Tumors

Cited by 107 publications

References 33 publications

Abdominal Surgery in Patients with Midgut Carcinoid Tumors

Abdominal Surgery in Patients with Midgut Carcinoid Tumors

Small bowel neuroendocrine tumors: From pathophysiology to clinical approach

Management of patients with differentiated neuroendocrine tumors of jejunum and ileum (according to international guidelines)

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