Surgical treatment and clinical outcome of large pediatric interhemispheric cysts with callosal agenesis: A systematic literature review with four additional patients

Ferrera, Giulia; Vetrano, Ignazio G.; Chiapparini, Luisa; Moscatelli, Marco; Taddei, Matilde; Erbetta, Alessandra; Valentini, Laura; Saletti, Veronica

doi:10.1016/j.clineuro.2021.106600

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Currently, there is a discussion if early intervention in asymptomatic individuals results in improved outcomes. Recent discussions focused on monitoring asymptomatic individuals closely for the emergence of symptoms before intervening [ 14 ]. Symptoms due to increased cranial pressure, such as headaches, dizziness, epilepsy, and psychomotor retardation, are the main indicators for intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms due to increased cranial pressure, such as headaches, dizziness, epilepsy, and psychomotor retardation, are the main indicators for intervention. However, the relationship between interhemispheric cysts and increased cranial pressure is not clearly established [ 14 ]. As such, surgical intervention to resect an interhemispheric cyst, which may not be the causal entity, can result in suboptimal outcomes in as much as 72% of patients [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…As such, surgical intervention to resect an interhemispheric cyst, which may not be the causal entity, can result in suboptimal outcomes in as much as 72% of patients [ 15 ]. In comparison, in patients where the cyst is the likely causal entity, intervention can lead to substantially improved outcomes through the reduction of cranial pressure [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Adult Radiographic Presentation of Corpus Callosal Agenesis With a Single Interhemispheric Cyst and Dandy-Walker Malformation: A Case Report

Morgan¹,

Ciubuc²,

Murray³

et al. 2023

Cureus

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Agenesis or dysgenesis of the corpus callosum may occur due to ischemic, toxic, traumatic, or another insult to the fetus in the first trimester. Occasionally, such a malformation is associated with an interhemispheric cyst, among other central nervous system anomalies. Holoprosencephaly tends to mimic this radiographic presentation, which is where key imaging findings are helpful to differentiate between these entities. We present a 56-year-old male patient who was found to have a monoventricle, corpus callosum agenesis, interhemispheric cyst, and a Dandy-Walker malformation. The patient presented with a right acetabular fracture with computed tomography (CT) of the brain revealing the congenital brain abnormalities. The patient’s past medical history was notable for a seizure disorder identified during early adulthood. The CT scan of the head revealed a large monoventricle with an associated midline dorsal interhemispheric cyst and a Dandy-Walker malformation. The absence of both the corpus callosum and septum pellucidum was noted, with the presence of a monoventricle, leading to an initial differential of holoprosencephaly. Further review of the findings suggested instead a rare congenital presentation consisting of corpus callosum agenesis and an interhemispheric cyst. This case highlights a unique radiographic presentation of multiple brain anomalies, rarely presented in non-pediatric literature, which may help determine appropriate surgical and medical management for similarly affected adult individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adult Radiographic Presentation of Corpus Callosal Agenesis With a Single Interhemispheric Cyst and Dandy-Walker Malformation: A Case Report

Morgan¹,

Ciubuc²,

Murray³

et al. 2023

Cureus

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“…In some cases of ACC in which an interhemispheric cyst is also present, hydrocephalus may occur. In these cases, imaging surveillance is important, since neurosurgery may be required 17,51,52 . These surgeries do not treat the underlying ACC, but rather target the co‐occurring abnormality 17,51,52 …”

Section: Options For Therapymentioning

confidence: 99%

“…In these cases, imaging surveillance is important, since neurosurgery may be required 17,51,52 . These surgeries do not treat the underlying ACC, but rather target the co‐occurring abnormality 17,51,52 …”

Section: Options For Therapymentioning

confidence: 99%

Agenesis of the corpus callosum: What to tell expecting parents?

Tsai,

Shinar

2023

Prenatal Diagnosis

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Agenesis of the corpus callosum (ACC) is one of the most common brain malformations, with an incidence estimated to range from 0.5 to 70 in 10,000 among the general population. Prenatal diagnosis is made via ultrasound; however, fetal MRI is useful to confirm or exclude the presence of associated cerebral abnormalities–mostly cortical malformations–that may affect postnatal prognosis. When no additional central nervous system (CNS) or extra CNS anomalies are identified and no genetic cause is found, an isolated ACC is diagnosed. Overall, in cases of ACC, an underlying genetic cause can be identified in up to 12.5% with chromosomal microarray (CMA) and up to 47% with whole exome sequencing (WES). In cases where ACC is the only anomaly detected, the yield of WES is 30%. Postnatal outcomes are variable and depend on whether the condition is isolated or not. In truly isolated ACC, outcomes range from normal in 65% of cases through mild to severe neurodevelopmental impairments in 35% of cases. An interdisciplinary team of medical experts is key in guiding parents toward informed decision‐making in pregnancies complicated by ACC. Considering current and expected advancements in genetic testing and imaging technologies in upcoming years, we herein summarize current recommendations for the management and prenatal counseling of expecting parents of fetuses with ACC. Our review pertains primarily to expecting parents of fetuses with complete ACC.

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Imaging characteristics and neurosurgical outcome in subjects with agenesis of the corpus callosum and interhemispheric cysts

Severino

Tortora

Reid³

et al. 2022

Neuroradiology

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Surgical treatment and clinical outcome of large pediatric interhemispheric cysts with callosal agenesis: A systematic literature review with four additional patients

Cited by 7 publications

References 30 publications

Adult Radiographic Presentation of Corpus Callosal Agenesis With a Single Interhemispheric Cyst and Dandy-Walker Malformation: A Case Report

Adult Radiographic Presentation of Corpus Callosal Agenesis With a Single Interhemispheric Cyst and Dandy-Walker Malformation: A Case Report

Agenesis of the corpus callosum: What to tell expecting parents?

Imaging characteristics and neurosurgical outcome in subjects with agenesis of the corpus callosum and interhemispheric cysts

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