Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years

Niu, Xiaodong; Wang, Tianwei; Zhou, Xingwang; Yang, Yuan; Wang, Xiang; Zhang, Haodongfang; Chen, Ni; Ye, Qiang; Feng, Wang; Zhang, Yuekang; Liu, Yan‐Hui; Mao, Qing

doi:10.1007/s11060-020-03430-x

Cited by 17 publications

(16 citation statements)

References 47 publications

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“… 8 There was selection bias in our study because we only analyzed the surgical cases; nonetheless, the PFS and OS were longer than those previously reported for both H3K27M-mutant and H3 wild-type gliomas. 8 , 11–13 In the present series, the patients with the survival of >60 months were found in both the H3K27M-mutant and wild-type groups. Therefore, our results suggest that surgical resection has improved the survival outcome of adult thalamic HGGs harboring H3K27M-mutant and H3 wild-type status.…”

Section: Discussionmentioning

confidence: 84%

“… 11–13 In the literature, some studies have reported the survival benefits of surgical resection for patients with thalamic gliomas. 5 , 7 , 8 , 24 A recent relatively large study involving 102 patients with adult thalamic gliomas reported by Niu et al showed that gross total resection plus chemoradiotherapy provided a significant benefit in terms of OS compared with other treatment regimens. 8 There was selection bias in our study because we only analyzed the surgical cases; nonetheless, the PFS and OS were longer than those previously reported for both H3K27M-mutant and H3 wild-type gliomas.…”

Section: Discussionmentioning

confidence: 99%

“… 5 , 7 , 8 , 24 A recent relatively large study involving 102 patients with adult thalamic gliomas reported by Niu et al showed that gross total resection plus chemoradiotherapy provided a significant benefit in terms of OS compared with other treatment regimens. 8 There was selection bias in our study because we only analyzed the surgical cases; nonetheless, the PFS and OS were longer than those previously reported for both H3K27M-mutant and H3 wild-type gliomas. 8 , 11–13 In the present series, the patients with the survival of >60 months were found in both the H3K27M-mutant and wild-type groups.…”

Section: Discussionmentioning

confidence: 99%

“…However, malignant thalamic gliomas remain associated with a poor prognosis. 5 , 7 , 8 …”

mentioning

confidence: 99%

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H3K27M andTERTpromoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma

Osada

Saito

Shibahara

et al. 2021

Neuro-Oncology Advances

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Background Thalamic high-grade gliomas (HGGs) are rare tumors with a dismal prognosis. H3K27M and telomerase reverse transcriptase promoter (TERTp) mutations reportedly contribute to poor prognoses in HGG cases. We investigated the outcomes of surgically treated adult thalamic HGGs to evaluate the prognostic significance of H3K27M and TERTp mutations. Methods We retrospectively analyzed 25 adult patients with thalamic HGG who underwent maximum surgical resection from January 1997 to March 2020. The histological and molecular characteristics, progression-free survival (PFS), and overall survival (OS) of the patients were compared. For molecular characteristics, target sequencing was used to determine the H3F3A, HIST1H3B, and TERTp mutations. Results H3K27M mutations were detected in 12/25 (48.0%) patients. TERTp mutations were not detected in H3K27M-mutant gliomas but were detected in 8/13 (61.5%) of H3 wild-type gliomas. Although it was not significant, H3K27M-mutant gliomas tended to have a shorter PFS (6.7 vs. 13.1 months; P = 0.2928) and OS (22.8 vs. 24.4 months; P = 0.2875) than H3 wild-type gliomas. Moreover, the prognosis of TERTp-mutant gliomas was as poor as that of H3K27M-mutant gliomas. Contrary, five gliomas harboring both H3 and TERTp wild-type showed a better median PFS (59.2 vs. 6.4 months; P = 0.0456) and OS (71.8 vs. 24.4 months; P = 0.1168) than those harboring H3K27M or TERTp mutations. Conclusions TERTp-mutant gliomas included in the H3 wild-type glioma group limited patient survival as they exhibited an aggressive course similar to H3K27M-mutant gliomas. Comprehensive molecular work-up for the H3 wild-type cases may further confirm this finding.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…However, malignant thalamic gliomas remain associated with a poor prognosis. 5 , 7 , 8 …”

mentioning

confidence: 99%

See 2 more Smart Citations

H3K27M andTERTpromoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma

Osada

Saito

Shibahara

et al. 2021

Neuro-Oncology Advances

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show abstract

“…Thalamic gliomas are rare neoplasms, accounting for 1% of all intracranial tumors in adults [1]. The 2016 WHO classification of the CNS tumors distinguishes gliomas into diffuse and non-diffuse types and incorporates molecular parameters for further subclassifications [2].…”

Section: Introductionmentioning

confidence: 99%

Thalamic gliomas in adults: a systematic review of clinical characteristics, treatment strategies, and survival outcomes

et al. 2021

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Purpose Thalamic gliomas are rare neoplasms that pose significant surgical challenges. The literature is limited to singleinstitution retrospective case series. We systematically review the literature and describe the clinical characteristics, treatment strategies, and survival outcomes of adult thalamic gliomas. Methods Relevant articles were identified on PubMed, Scopus, and Cochrane databases. Papers containing cases of adult thalamic gliomas with clinical outcome data were included. A comprehensive review of clinical characteristics and survival analysis was conducted. ResultsWe included 25 studies comprising 617 patients. The median age was 45 years (male = 58.6%). Glioblastoma was the most frequent histological type (47.2%), and 82 tumors were H3 K27M-mutant. Motor deficit was the most common presenting symptom (51.8%). Surgical resection was performed in 69.1% of cases while adjuvant chemotherapy and radiotherapy were administered in 56.3% and 72.6%, respectively. Other treatments included laser interstitial thermal therapy, which was performed in 15 patients (2.4%). The lesion laterality (P = 0.754) and the surgical approach (P = 0.111) did not correlate with overall survival. The median progression-free survival was 9 months, and the overall two-year survival rate was 19.7%. The two-year survival rates of low-grade and high-grade thalamic gliomas were 31.0% and 16.5%, respectively. H3 K27M-mutant gliomas showed worse overall survival (P = 0.017). Conclusion Adult thalamic gliomas are associated with poor survival. Complete surgical resection is associated with improved survival rates but is not always feasible. H3 K27M mutation is associated with worse survival and a more aggressive approach should be considered for mutant neoplasms.

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Prognostic nomogram models for predicting survival probability in elderly glioblastoma patients

Niu

Chang

Yang

et al. 2023

J Cancer Res Clin Oncol

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Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years

Cited by 17 publications

References 47 publications

H3K27M andTERTpromoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma

H3K27M andTERTpromoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma

Thalamic gliomas in adults: a systematic review of clinical characteristics, treatment strategies, and survival outcomes

Prognostic nomogram models for predicting survival probability in elderly glioblastoma patients

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