Surgical Treatment for Colorectal Cancer

Hiranyakas, Art; Ho, Yik‐Hong

doi:10.9738/cc18.1

Cited by 6 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical procedures include open and laparoscopic colorectal cancer surgery. Laparoscopic surgery has been shown to improve short-term clinical and oncologic outcomes [ 12 , 13 ], including shortened hospital stays, fewer postoperative complications and accelerated rehabilitation [ 14 ]. Thus, laparoscopic-assisted colectomy has been widely accepted for the treatment of mucosal or submucosal carcinoma, whereas open surgery is preferably used to treat advanced cancer [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a preoperative prediction model for colorectal cancer T-staging based on MDCT images and clinical information

et al. 2017

Oncotarget

View full text Add to dashboard Cite

ObjectivesThis study aimed to establish and evaluate the efficacy of a prediction model for colorectal cancer T-staging.ResultsT-staging was positively correlated with the level of carcinoembryonic antigen (CEA), expression of carbohydrate antigen 19-9 (CA19-9), wall deformity, blurred outer edges, fat infiltration, infiltration into the surrounding tissue, tumor size and wall thickness. Age, location, enhancement rate and enhancement homogeneity were negatively correlated with T-staging. The predictive results of the model were consistent with the pathological gold standard, and the kappa value was 0.805. The total accuracy of staging improved from 51.04% to 86.98% with the proposed model.Materials and MethodsThe clinical, imaging and pathological data of 611 patients with colorectal cancer (419 patients in the training group and 192 patients in the validation group) were collected. A spearman correlation analysis was used to validate the relationship among these factors and pathological T-staging. A prediction model was trained with the random forest algorithm. T staging of the patients in the validation group was predicted by both prediction model and traditional method. The consistency, accuracy, sensitivity, specificity and area under the curve (AUC) were used to compare the efficacy of the two methods.ConclusionsThe newly established comprehensive model can improve the predictive efficiency of preoperative colorectal cancer T-staging.

show abstract

Section: Discussionmentioning

confidence: 99%

Development and validation of a preoperative prediction model for colorectal cancer T-staging based on MDCT images and clinical information

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Surgery may be curative or palliative and is sometimes combined with chemotherapeutic regimes to achieve pre-operative tumor shrinkage (Zhao et al, 2010). Minimally invasive approaches such as laparoscopic surgery for colonic tumors are reported to offer improved short-term clinical outcomes (Hiranyakas & Ho, 2011). Chemotherapeutic regimes include infusional combination therapies such as FOLFIRI that combine irinotecan, 5-fluorouracil and leucovorin, and FOLFOX that combines oxaliplatin, 5-fluorouracil and leucovorin (Lee & Chu, 2007;Garcia-Foncillas & Diaz-Rubio, 2010).…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%