Surgical Treatment of a Giant Neurofibroma

Cheng, Xigao; Lei, Delin; Liu, Yunpeng; Tian, Li; Liu, Yanpu; Feng, Xinghua; Hu, Xiaoguang; Sun, Miao; Ma, Qin; Mao, Tianqiu; Liu, Baolin; Zhao, Yimin; Feng, Zhihong; Xu, Lixian; Zhang, Hui; Zhang, Tie-Cheng; Liu, Rui; Shen, Lei

doi:10.1097/scs.0b013e31823270cb

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…[4–6] However, we agree that the most difficult challenge for this surgery is the variation of anatomy and unclear tumor margin. In addition, the tumor contains thickened cord of nerves along with abundant abnormal vessels; therefore, excessive hemorrhage during the operation is also a brainteaser.…”

Section: Discussionmentioning

confidence: 96%

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Lady with wings

Maharjan

Li²,

Cui³

et al. 2017

Medicine

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Rationale:Neurofibromatosis type I (NF-I) accounts for approximately 90% of neurofibromatosis. NF-I is an autosomal dominant genetic disease which results from the gene mutation of NF-I situated in chromosome 17q11.2.Patient concerns:A 32-year-old lady presented with a giant wing like structure on her back which started growing from her childhood.Diagnosis:A diagnosis of NF-I was confirmed as she presented with multiple cutaneous nodules, multiple café-au-lait macules of different sizes, scoliosis deformity, and positive family history of neurofibroma.Interventions:Surgical excision of tumor and multiple Z plasty reconstruction of the back was carried out.Outcomes:The excised neurofibroma weighed 6.7 kg containing thickened nerves, nerve roots, and circuitous vessels. The histopathological report confirmed plexiform and diffuse type cutaneous neurofibroma without any malignant transformation. Surgical excision and reconstruction with regular follow-up is an excellent choice of treatment for such a giant neurofibroma as in this case.Lessons:NF-I is a genetic disease which could present as a giant cutaneous neurofibroma. One of the treatment options for giant neurofibromas causing deformity and physical disability is by surgical excision and histopathological examination with regular follow-up for NF-I recurrence.

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Section: Discussionmentioning

confidence: 96%

“…[1,2] NF-I accounts for approximately 90% cases of neurofibromatosis. [3] Although, there are many reports on giant neurofibromas, [4–6] only few of them are complex neurofibromas consisting of plexiform and diffuse cutaneous neurofibromas. We report a case of giant wing like neurofibroma at the back of a 32-year-old lady.…”

Section: Introductionmentioning

confidence: 99%

Lady with wings

Maharjan

Li²,

Cui³

et al. 2017

Medicine

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“…Management of huge plexiform neurofibromatosis is usually surgery. [4][5][6] Indications For Resection of plexiform neurofibromatosis include infection, cosmetic, intractable pain, neurological deficit, suspected malignant transformation, and progressive enlargement with compressive effects. 7 In our case, the resection was done for infected mass, cosmetic and giant mass caused neck extension.…”

Section: Discussionmentioning

confidence: 99%

Posterior Neck Gigantic Plexiform Neurofibromatosis

Mat¹,

Suhairi²,

Hafizi³

et al. 2018

Int. J. Hum. Health Sci.

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Neurofibromatosis (NF) is one of the most common genetic disorders. It is an autosomal dominant genetic disorder. It primarily affects the neural tissues. Neurofibromatosis type I (NF-1) also known as well as Recklinghausen’s disease is the most common type. We present a case of a 62-year-old lady with NF-1. The disease was apparent since childhood with appearance of multiple hyper-pigmented skin macules. With time, more cutaneous lesions appeared and grew bigger all over the body surface. Because of huge neurofibromatosis over posterior neck, patient came for further treatment.International Journal of Human and Health Sciences Vol. 02 No. 04 October’18. Page : 236-238

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“…16 With regard to the treatment of these giant tumors, surgical treatment still remains the mainstream, aiming at improving functional and aesthetic effect. [17][18][19] There is a conflict amongst literature about the right time and extent of PN resection. Some literature suggests that removal of PN in early stage can restricts the extent of local involvement.…”

Section: Introductionmentioning

confidence: 99%

Isolated giant plexiform neurofibroma of lower back: a rare case presentation

Mishra¹,

Wasnik

Sakarkar

2020

Int Surg J

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Plexiform neurofibroma is a rare benign tumor of the peripheral tissue cells that develops in the perineurium that is often considered pathognomonic of neurofibromatosis type 1 (NF1 or von Recklinghausen disease). They occur most frequently in the craniomaxillofacial region, rarely on back and extremities. They are extremely vascular and there is 15-20% potential for malignant transformation. A 35-year-old married female presented with painless swelling in left lower back that began at around 8 years of age. The swelling gradually increased in size. The patient reported embarrassment over the disfigurement caused by the mass. Her medical history was unremarkable and none of the relatives was known to be affected. Surgical resection of the swelling with primary closure was done. Histopathology findings were consistent with neurofibromatosis. Hereby reporting a rare case of isolated plexiform neurofibroma of lower back which was surgically cured as a perusal of rare entity. We also try to emphasize on the need of sprightful clinical diagnosis with multidisciplinary approach in the management of these type of tumors. Finally, we insist on the need of a long term clinical and radiological follow-up of these patients to assess post resection recurrence or malignant transformation.

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Surgical Treatment of a Giant Neurofibroma

Cited by 6 publications

References 5 publications

Lady with wings

Lady with wings

Posterior Neck Gigantic Plexiform Neurofibromatosis

Isolated giant plexiform neurofibroma of lower back: a rare case presentation

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