The article presents the results of the treatment of elderly and senile patients with complications of colon cancer, in the perioperative care of which a multidisciplinary approach is used. The peculiarity of patients of older age groups is caused by polymorbidity, the phenomenon of mutual burdening. This requires the use of a non-standard approach in the treatment of complicated colon cancer. A comparative analysis of the results of the treatment of 289 elderly and senile patients with complicated colon cancer with a traditional method and using a multidisciplinary approach is conducted. The patients are distributed into two groups (main and control). In addition to introducing the principles of a multidisciplinary approach, additional diagnostic methods for more specific determination of the type, severity of complications and functional operability are used in the main group. Taking into account the implementation of a multidisciplinary approach, the operations for patients of the main group are performed using endovideosurgical technologies. A more favorable course of the postoperative period with a decrease in post-surgical complications (from 44.9 to 27.8%) and mortality (from 8.9 to 5.3%) is noted in the group of patients, in which a multidisciplinary approach and modern methods of diagnostics and treatment are used.