Surgical Treatment of Colorectal Cancer Liver Metastases

Заривчацкий, М Ф; Мугатаров, И. Н.; Каменских, Е. Д.; Blinov, S A; Денисов, С. А.; Кравцова, Т. Ю.

doi:10.16931/1995-5464.2018-1-80-87

Cited by 4 publications

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“…Surgical treatment of thyroid gland (TG) diseases is one of the priority areas in modern medical science as the number of patients with thyroid pathology is constantly increasing. Therefore, the prevalence of thyroidopathies in the Russian Federation averages at 10%, and morbidity rate is 50 new cases per 100 000 population per year [1][2][3]. Consequently, the number of surgical interventions on the thyroid gland inevitably increases.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the number of surgical interventions on the thyroid gland inevitably increases. Owing to the possibility of conducting adequate replacement therapy with synthetic analogues of levothyroxine, thyroidectomy has become the operation of choice in treatment of not only thyroid malignancies, but also most benign thyroid diseases [2,3]. However, this type of surgical intervention can lead to failure of the parathyroid glands (PTG) function, caused by their injury or impaired blood supply [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review)

Melikyan¹,

Меньков²

2020

Sovrem Tehnol Med

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This review summarizes the results of studies concerning the problem of post-surgical hypoparathyroidism, a common complication of thyroid gland surgery, decreasing the quality of life in patients and, in some cases, leading to disability. A search for publications was carried out in electronic databases Web of Science, Scopus, Academic Search Complete (EBSCO), eLIBRARY, using keywords. The search depth was 7-10 years. Prevalence of post-surgical hypoparathyroidism was evaluated, the pathogenetic causes of the disease development, its clinical forms, methods of diagnosis and treatment were studied. It has been found that there is no single algorithm for analyzing the prognostic factors for the development of this pathological condition. It is emphasized that drug therapy of post-surgical hypoparathyroidism has a number of adverse effects. Therefore, the issues of prevention and surgical correction are of particular relevance. However, controversial opinions of contemporary authors about their clinical effectiveness determine the scientific and practical significance of further research on these issues.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review)

Melikyan¹,

Меньков²

2020

Sovrem Tehnol Med

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“…После повторной попытки резекции метастазов 5-летняя безрецидивная выживаемость достигается уже только у 20-40 % пациентов [28]. Ни один другой способ воздействия на опухолевую ткань, включая локальную деструкцию, не давал лучших отдаленных результатов [29].…”

Section: Introductionunclassified

The role of PET/CT with 18F-fluorodeoxyglucose in detecting the progression of colorectal cancer in asymptomatic patients with elevated level of сarcinoembryonic antigen (literature review)

Dolgushin

Михайлов

Гордеев

2019

Onkol. koloproktol.

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Совмещенная с компьютерной томографией позитронно-эмиссионная томография (ПЭТ / КТ) с использованием 18 F-фтордезоксиглюкозы при колоректальном раке представляет собой высокочувствительный метод визуализации, позволяющий выявлять злокачественные очаги, характеризующиеся повышенным метаболизмом глюкозы. В настоящее время все большее количество исследований показывают дополнительную ценность ПЭТ / КТ для диагностики прогрессирования колоректального рака. Особую проблему представляет группа пациентов, страдающих колоректальным раком, с отрицательными или неоднозначными результатами лучевых методов диагностики, но с повышенным уровнем раково-эмбрионального антигена. Многие исследования подтверждают мнение о том, что раннее использование ПЭТ / КТ с 18 F-фтордезоксиглюкозой может иметь прогностическую ценность в лечении таких пациентов.

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“…[3,4]. Существенные успехи гепатопанкреатобилиарной хирургии за последние годы привели к существенному сокращению объемов трансфузионных сред в интраоперационном и послеоперационном периодах, снижению количества послеоперационных осложнений и летальности [5][6][7][8].…”

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Coagulological disorders during liver resections in patients with malignant tumors

Zarivchatskiy,

Kamenskikh,

Mugatarov

et al. 2024

ECG

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The purpose of the study. To study the coagulation profile of patients undergoing liver resections using laboratory tests and thromboelastography. Materials and methods. The results of observation of coagulological changes in 45 patients were studied: with colorectal liver metastases - 24 (53.3%) cases, with hepatocellular cancer - 14 (31.1%), with cholangiocellular cancer - 7 (15.6%). Right-sided hemihepatectomy was performed in 22 (48.9%) patients, right-sided extended hemihepatectomy - in 7 (15.6%), left-sided hemihepatectomy - in 8 (17.8%), resection of the left sector - in 8 (17.8%). Laboratory diagnostics included standard conventional coagulation tests and thromboelastography. Results. The concentrations of total bilirubin and alkaline phosphatase significantly increased up to 3 days of the postoperative period inclusive. The international normalized ratio increased significantly after liver resection immediately after surgery, as well as after 1, 3 and 5 days of observation. The level of fibrinogen in the first day after surgery decreases, and then increased to the initial value. Thromboelastometric parameters indicated a stable and normal coagulation function with a short ability to hypercoagulate immediately after liver resection. Conclusion. Although standard routine laboratory tests such as activated partial thromboplastin time and international normalized ratio may remain within normal limits or indicate hypocoagulation, the patient may be at risk for thrombosis. Thromboelastography measures the rate of formation, stabilization, and lysis of a clot using whole blood, which gives a more complete picture of coagulation status. Thus, routine laboratory parameters alone should not be used to decide whether to delay thromboembolic prophylaxis after liver resection.

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Surgical Treatment of Colorectal Cancer Liver Metastases

Cited by 4 publications

References 0 publications

Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review)

Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review)

The role of PET/CT with 18F-fluorodeoxyglucose in detecting the progression of colorectal cancer in asymptomatic patients with elevated level of сarcinoembryonic antigen (literature review)

Coagulological disorders during liver resections in patients with malignant tumors

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