Surgical treatment of congenital cystic adenomatoid malformation: a retrospective study of single tertiary center experience

Xia, Bo; Yu, Gang; Liu, Cuifen; Hong, Chun; Jing, Tang

doi:10.1080/14767058.2016.1174988

Cited by 13 publications

(11 citation statements)

References 16 publications

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“…Intriguingly, we found that all 10 patients with CPAM‐associated breathing symptoms were in the group of CVR less than 1.0 in our study cohort. Moreover, we observed no significant difference in CVR between the asymptomatic and symptomatic groups, which was consistent with the findings from the study by Xia et al 10 Our results indicated that CVR was not a good predictor of long‐term outcomes, and that close follow up was needed, even for those patients whose CVR was less than 1.0.…”

Section: Discussionsupporting

confidence: 92%

“…A systematic review suggested that CVR ranging from 0.5 to 1.0 on the initial ultrasound scan could have the greatest predictive value for neonatal outcomes 15 . However, other research reported that CVR was not a statistically significant indicator of prognosis 10 . Intriguingly, we found that all 10 patients with CPAM‐associated breathing symptoms were in the group of CVR less than 1.0 in our study cohort.…”

Section: Discussioncontrasting

confidence: 48%

“…Observational studies have shown that asymptomatic patients tend to be in a stable condition after conservative management and that in some individuals the lesion disappears spontaneously after birth 6–8 . In contrast, other cohort studies have suggested that some patients can benefit from surgery as they are at risk of malignant transformation, recurrent infections or acute respiratory distress syndrome 9,10 …”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] In contrast, other cohort studies have suggested that some patients can benefit from surgery as they are at risk of malignant transformation, recurrent infections or acute respiratory distress syndrome. 9,10 The CPAM-to-volume ratio (CVR), measured at the prenatal ultrasound examination, has been reported to be useful in predicting the development of hydrops and neonatal outcomes. Prenatally, CVR is a good predictor, and it was generally recognized that a CVR greater than 1.6 indicates a poor prognosis with hydrops and antenatal steroid use.…”

mentioning

confidence: 99%

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Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long‐term prognosis: A retrospective cohort study

Xiao

Zhao

et al. 2021

Intl J Gynecology & Obste

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Objective To investigate the relationship between mild congenital pulmonary airway malformation (CPAM) and its long‐term prognosis in childhood and to explore whether surgery is necessary. Methods We conducted a retrospective cohort of fetuses with mild CPAM diagnosed prenatally with available long‐term outcomes in childhood from 2004 to 2016. The patients were divided into two groups according to the fetal CPAM‐to‐volume ratio (CVR) of less than 1.0 and 1.0–1.6. The primary outcome was a postnatal composite outcome including CPAM‐associated respiratory symptoms and surgical resection of the lesion. The secondary outcomes included neonatal asphyxia, perinatal morbidity and mortality. Results Forty‐two fetuses were identified as having CVR <1.0 or CVR‐1.0–1.6 respectively (n = 37 vs n = 5; 88.1% vs 11.9%), with the median duration of follow up 2.15 years (0.3–10.8 years). Of 42 patients, 32 (76%) remained asymptomatic without recurrent respiratory symptoms or surgical resection; the other 10 with CVR <1.0 had respiratory symptoms. Of 10 symptomatic cases, five recovered after expectant treatment, and five underwent resection, for an increase in lesion size and recurrent respiratory infection. Conclusion Patients with CVR <1.0 still need to be closely observed after birth. Conservative management is a reasonable option in asymptomatic cases, but surgery might be necessary in some.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long‐term prognosis: A retrospective cohort study

Xiao

Zhao

et al. 2021

Intl J Gynecology & Obste

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“…[ 1 ] Surgical removal of the lesion is considered the gold standard for all patients with CCAMs who became symptomatic. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

A “blind” vascular ring in association with congenital cystic adenomatoid malformation

et al. 2017

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Rationale:The occurrence of congenital cystic adenomatoid malformation (CCAM) and vascular ring (VR) is extremely rare.Patient concerns:We present a case of left CCAM with VR consisting of a left aortic arch and right descending aorta with left tracheal compression causing atelectasis.Diagnoses:A high-risk male neonate with the diagnosis of left CCAM was diagnosed at 20 weeks gestational age by antenatal ultrasound. Chest CT revealed multiple cysts in the left inferior lung. Cardiac CT showed VR consisting of a left aortic arch and right descending aorta with left tracheal compression causing atelectasis.Interventions:left inferior lobectomy was performed. Cardiac CT showed VR consisting of a left aortic arch and right descending aorta with left tracheal compression causing atelectasis. Descending aorta transposition was performed.Outcomes:The patient recovered smoothly and remained asymptomatic during the 12-months of postoperative follow-up period.Lessons:We report this rare case of CCAM with VR consisting of left aortic arch and right descending aorta with left tracheal compression causing atelectasis. From the findings of this report, early surgical treatment is recommended. Although the prognosis after surgery remained good, second surgery can be avoided if VR was detected early.

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Relative Mediastinal Displacement Index (RMDI): A Prenatal MRI Indicator of Adverse Events in Fetuses With Isolated Left Congenital Diaphragmatic Hernia

Wu,

Chen,

Zhang

et al. 2024

Magnetic Resonance Imaging

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BackgroundExtracorporeal membrane oxygenation (ECMO), has partly improved congenital diaphragmatic hernia (CDH) outcomes, yet the overall morbidity and mortality remain high. Existing prenatal indicators for CDH fetuses are operator‐dependent, time‐consuming, or less accurate, a new simple and accurate indicator to indicate adverse events in CDH patients is needed.PurposeTo propose and assess the association of a new MRI parameter, the relative mediastinal displacement index (RMDI), with adverse events including in‐hospital deaths or the need for ECMO in fetuses with isolated left CDH (iLCDH).Study TypeRetrospective analysis.SubjectsOne hundred thirty‐nine fetuses were included in the iLCDH group (24 with adverse events and 115 without) and 257 fetuses were included in the control group from two centers in Guangzhou.Field Strength/Sequence3.0 T, T2WI‐TRUFI; 1.5 T, T2WI‐FIESTA.AssessmentThree operators independently measured the , , and DH on the axial images. The calculation formula of the RMDI was ( + )/DH.Statistical TestsThe independent sample t test, Mann–Whitney U test, Chi‐square test, Chi‐square test continuity correction, Fisher's test, linear regression analysis, logistic regression analysis, intraclass correlation coefficient, receiver operating characteristic curve analysis, and Delong test. A P value <0.05 was considered statistically significant.ResultsThe RMDI did not change with gestational age in the iLCDH group (with [P = 0.189] and without [P = 0.567] adverse events) and the control group (P = 0.876). There were significant differences in RMDI between the iLCDH group (0.89 [0.65, 1.00]) and the control group (−0.23 [−0.34, −0.16]). In the iLCDH group, RMDI was the only indicator left for indicating adverse events, and the best cutoff value was 1.105. Moreover, there was a significant difference in diagnostic accuracy between the RMDI (AUC = 0.900) and MSA (AUC = 0.820), LHR (AUC = 0.753), o/e LHR (AUC = 0.709), and o/e TFLV (AUC = 0.728), respectively.Data ConclusionThe RMDI is expected to be a simple and accurate tool for indicating adverse events in fetuses with iLCDH.Evidence Level4Technical EfficacyStage 1

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Surgical treatment of congenital cystic adenomatoid malformation: a retrospective study of single tertiary center experience

Cited by 13 publications

References 16 publications

Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long‐term prognosis: A retrospective cohort study

Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long‐term prognosis: A retrospective cohort study

A “blind” vascular ring in association with congenital cystic adenomatoid malformation

Relative Mediastinal Displacement Index (RMDI): A Prenatal MRI Indicator of Adverse Events in Fetuses With Isolated Left Congenital Diaphragmatic Hernia

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