Surgical Treatment of Early-Stage Cervical Cancer

Brucker, Sara; Ulrich, U.

doi:10.1159/000448794

Cited by 43 publications

(37 citation statements)

References 43 publications

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“…CC occurs frequently in women worldwide and one woman dies because of CC every 2 minutes. Currently, there is no effective cure to this cancer, especially to high‐risk patients …”

Section: Discussionmentioning

confidence: 99%

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

Zhao

Yuan

et al. 2018

J of Cellular Biochemistry

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Cervical cancer (CC) is one of the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes, which has been reported to significantly alter the cellular physiology of tumor cells. However, little is known about the role of phospholipid scramblase 1 (PLSCR1) in pathogenesis of CC. Here, we demonstrated that resveratrol could significantly inhibit both the growth of HeLa cells and expression of PLSCR1. These results suggest that resveratrol‐mediated cell growth inhibition can be regulated by PLSCR1.

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“…CC occurs frequently in women worldwide and one woman dies because of CC every 2 minutes. Currently, there is no effective cure to this cancer, especially to high‐risk patients …”

Section: Discussionmentioning

confidence: 99%

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

Zhao

Yuan

et al. 2018

J of Cellular Biochemistry

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“…The current treatments for cervical cancer are mainly surgical resection and chemotherapy [ 2 ]. However, surgical treatment is only suitable for patients with early cervical cancer, and is ineffective for advanced cervical cancer [ 3 ]. On the other hand, drugs commonly used in chemotherapy such as cisplatin and 5-fluorouracil are expensive and have strong side-effects.…”

Section: Introductionmentioning

confidence: 99%

Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells

Shao

Wang

et al. 2018

IJMS

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Cervical cancer is a common gynecological malignancy with high incidence and mortality. Drugs commonly used in chemotherapy are often accompanied by strong side-effects. To find an anti-cervical cancer drug with high effects and low toxicity, luteoloside was used to treat the cervical cancer cell line Hela to investigate its effects on cell morphology, proliferation, apoptosis, and related proteins. The study demonstrated that luteoloside could inhibit proliferation remarkably; promote apoptosis and cytochrome C release; decrease the mitochondrial membrane potential and reactive oxygen species level; upregulate the expression of Fas, Bax, p53, phospho-p38, phospho-JNK, and cleaved PARP; downregulate the expression of Bcl-2 and phospho-mTOR; activate caspase-3 and caspase-8; change the nuclear morphology, and fragmentate DNA in Hela cells. These results strongly suggest that luteoloside can significantly inhibit the proliferation and trigger apoptosis in Hela cells. In contrast, luteoloside had less proliferation inhibiting effects on the normal cell lines HUVEC12 and LO2, and minor apoptosis promoting effects on HUVEC12 cells. Furthermore, the luteoloside-induced apoptosis in Hela cells is mediated by both intrinsic and extrinsic pathways and the effects of luteoloside may be regulated by the mitogen-activated protein kinases and mTOR signaling pathways via p53.

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“…Accordingly, the analysis has included multiple treatments for cervical cancer, which include surgery, radiotherapy and chemotherapy. 29,30 There is a paucity of published evidence surrounding patients transitioning between the different diagnosed and undiagnosed FIGO stages of cervical cancer. Hence, inclusion of these health states may have increased inherent uncertainty within the model.…”

Section: Discussionmentioning

confidence: 99%

<p>Cost-Effectiveness and Cost-Benefit of Cervical Cancer Screening with Liquid Based Cytology Compared with Conventional Cytology in Germany</p>

Armstrong¹,

Guest²

2020

CEOR

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Objective: To assess the health economic impact of cervical screening with liquid based cytology (LBC) compared with conventional cytology (CC) in Germany.Methods: An economic model was constructed depicting the management of a hypothetical cohort of women aged ≥20 years who undergo cervical screening in Germany. The model estimated the cost-effectiveness and cost-benefit of LBC compared with CC at 2017/18 prices over a time-horizon of 70 years. Results: Performing cervical screens with LBC instead of CC is expected to increase the probability of detecting a true positive over a subject's lifetime by 73% (0.038 versus 0.022) and of diagnosing a subject with stage 3 cervical intraepithelial neoplasia (CIN3) (0.019 versus 0.011). Women screened with LBC instead of CC are expected to have a 57% reduction in the probability of having undetected CIN3 (0.006 versus 0.014) and to experience a 44% reduction in the probability of transitioning into disease progression (from 0.018 to 0.010). The mean discounted lifetime cost of healthcare resource use associated with performing cervical screens with LBC and CC was estimated at €4852 and €7523 per subject respectively. For every Euro invested in cervical screening with LBC instead of CC, the German healthcare system could potentially save~€170 over a subject's lifetime. Conclusion: Within the study's limitations, the analysis showed that LBC affords a costeffective cervical screening test compared with CC in Germany, since it improves detection rates and has the potential to lead to a reduction in disease progression for less cost. ClinicoEconomics and Outcomes Research Dovepressopen access to scientific and medical research Open Access Full Text Article submit your manuscript | www.dovepress.com ClinicoEconomics and Outcomes Research 2020:12 153-166

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Surgical Treatment of Early-Stage Cervical Cancer

Cited by 43 publications

References 43 publications

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells

<p>Cost-Effectiveness and Cost-Benefit of Cervical Cancer Screening with Liquid Based Cytology Compared with Conventional Cytology in Germany</p>

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