Surgical treatment of epidermolytic hereditary palmoplantar keratoderma

Surgical treatment of Papillon–Lefèvre Syndrome with bovine collagen and skin graft

“…1 Described in 1924, PLS represents a constellation of disorders characterized by diffuse palmoplantar hyperkeratosis and rapidly progressing periodontitis of primary and permanent dentation, resulting from an autosomal recessive point mutation in the cathepsin C gene. Incidence ranges from 1 to 4 per million worldwide, with more than 300 cases reported.…”