Surgical treatment of hepatic metastases from non-colorectal non-neuroendocrine tumours

Torra, J. Torras; Ramos, Emilio; Felip, Juan Figueras

doi:10.1007/bf02710033

Cited by 2 publications

(5 citation statements)

References 10 publications

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“…Our experience confirms earlier findings [ 29 , 30 ] showing that clamping of hepatic pedicle was not associated with any significant variation of the long-term survival. Similarly, the need of blood transfusion did not affect prognosis confirming the results of other authors [ 27 , 31 ]. Achieving a radical resection (R0) is one of the most important target to influence the prognosis after hepatic resection [ 12 , 16 , 32 , 33 ].…”

Section: Discussionsupporting

confidence: 88%

Prognostic Factors Affecting Long-Term Survival after Resection for Noncolorectal, Nonneuroendocrine, and Nonsarcoma Liver Metastases

Uggeri

Pinotti

Sandini

et al. 2017

Gastroenterology Research and Practice

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Aim To evaluate feasibility and long-term outcome after hepatic resection for noncolorectal, nonneuroendocrine, and nonsarcoma (NCNNNS) liver metastases in a single center. Methods We retrospectively reviewed our experience on patients who underwent surgery for NCNNNS liver metastases from 1995 to 2015. Patient baseline characteristics, tumor features, treatment options, and postoperative outcome were retrieved. Results We included 47 patients. The overall 5-year survival (OS) rate after hepatectomy was 27.6%, with a median survival of 21 months. Overall survival was significantly longer for patients operated for nongastrointestinal liver metastases when compared with gastrointestinal (41 versus 10 months; p = 0.027). OS was significantly worse in patients with synchronous metastases than in those with metachronous disease (10 versus 22 months; p = 0.021). The occurrence of major postoperative complication negatively affected long-term prognosis (OS 23.5 versus 9.0 months; p = 0.028). Preoperative tumor characteristics (number and size of the lesions), intraoperative features (extension of resection, need for transfusions, and Pringle's maneuver), and R0 at pathology were not associated with differences in overall survival. Conclusion Liver resection represents a possible curative option for patients with NCNNNS metastases. The origin of the primary tumor and the timing of metastases presentation may help clinicians to better select which patients could take advantages from surgical intervention.

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Section: Discussionsupporting

confidence: 88%

Prognostic Factors Affecting Long-Term Survival after Resection for Noncolorectal, Nonneuroendocrine, and Nonsarcoma Liver Metastases

Uggeri

Pinotti

Sandini

et al. 2017

Gastroenterology Research and Practice

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“…1 ). All studies were case series without matching control groups: 11 studies described more than 100 patients [ 16 , 24 , 26 , 29 , 34 – 37 , 41 , 43 , 44 ], 6 studies between 50 and 100 patients [ 15 , 17 , 31 , 38 , 39 , 42 ], and 13 studies less than 50 patients [ 18 – 23 , 25 , 27 , 28 , 30 , 32 , 33 , 40 ]. No prior systematic reviews or meta-analyses on this topic were identified.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-eight studies reported overall survival results (Table 1 ), which were unclear in one article [ 23 ]. Twenty-one studies reported data on progression-free survival [ 16 – 20 , 24 , 25 , 29 , 31 – 33 , 35 – 44 ]. Each article reported length of follow-up of at least 5 years.…”

Section: Resultsmentioning

confidence: 99%

“…The most common primary sites were breast (23.8 %), genito-urinary (21.8 %), and gastrointestinal tract (19.8 %). Sixteen studies included patients with extrahepatic metastases [ 16 – 18 , 24 , 25 , 27 – 31 , 33 , 36 , 37 , 42 – 44 ], whereas fourteen studies included patients with isolated liver disease only, or the presence of extrahepatic metastases at the time of hepatic resection was not specified [ 15 , 19 – 23 , 25 , 26 , 32 , 34 , 38 – 41 ]. The presence of extrahepatic disease wildly ranged between 0 and 53.1 % because several authors considered it an exclusion criterion for surgery, while others did not deem extrahepatic disease a contraindication or a negative prognostic factor.…”

Section: Resultsmentioning

confidence: 99%

“…Metastases affected two hepatic lobes in 0–37.5 % of patients. The presence of bilobar metastases or extrahepatic disease may not be considered as a contraindication for surgery [ 16 , 17 , 29 – 31 , 33 , 34 , 38 , 40 , 42 , 44 ]; 18 % of authors resected bilobar diseases, otherwise considering this criteria a prognostic factor that impact prognosis. Figure 3 also shows the results regarding the status of the surgical margin: although an R0 resection is always the primary objective of the surgeon, it is obtained in 2736 of the 3849 patients, although it is specified only in 21 studies.…”

Section: Resultsmentioning

confidence: 99%

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Metastatic liver disease from non-colorectal, non-neuroendocrine, non-sarcoma cancers: a systematic review

et al. 2015

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BackgroundHepatic resection of liver metastases of non-colorectal, non-neuroendocrine, and non-sarcoma (NCNNNS) primary malignancies seems to improve survival in selected patients. The aims of the current review were to describe long-term results of surgery and to evaluate prognostic factors for survival in patients who underwent resection of NCNNNS liver metastases.MethodsWe identified 30 full texts (25 single-center and 5 multicenter studies) published after year 1995 and published in English with a total of 3849 patients. For NCNNNS liver metastases, 83.4 % of these subjects were resected.ResultsNo prior systematic reviews or meta-analyses on this topic were identified. All studies were case series without matching control groups. The most common primary sites were breast (23.8 %), genito-urinary (21.8 %), and gastrointestinal tract (19.8 %). The median 5- and 10-year overall survival were 32.3 % (range 19–42 %) and 24 % (indicated only in two studies, range 23–25 %), respectively, with 71 % of R0 resections.ConclusionsThere is evidence suggesting that surgery of NCNNNS metastases is safe, feasible, and effective if treatment is part of a multidisciplinary approach and if indication is based on the prognostic factors underlined in literature analysis.

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Surgical treatment of hepatic metastases from non-colorectal non-neuroendocrine tumours

Cited by 2 publications

References 10 publications

Prognostic Factors Affecting Long-Term Survival after Resection for Noncolorectal, Nonneuroendocrine, and Nonsarcoma Liver Metastases

Prognostic Factors Affecting Long-Term Survival after Resection for Noncolorectal, Nonneuroendocrine, and Nonsarcoma Liver Metastases

Metastatic liver disease from non-colorectal, non-neuroendocrine, non-sarcoma cancers: a systematic review

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