Surgical Treatment of Invasive Squamous Cell Carcinoma of the Penis: Retrospective Analysis of 350 Cases

Ornellas, Antônio Augusto; Seixas, Antonio Luiz Correia; Marota, Alberto; Wisnescky, Aristóteles; Campos, Franz; Moraes, João Rangel De

doi:10.1016/s0022-5347(17)35222-9

Cited by 276 publications

(6 citation statements)

References 34 publications

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“…Similarly, Kosiba et al (SEER 2004-2016) identified 13,615 (79%) lymph node negative and 3669 (21%) lymph node positive organ-confined bladder cancer patients. In pT1b-pT3 SCCP patients, LNI rates range or even exceed 20% as reported by reputable institutional series (from 102 to 350 patients) [1][2][3][4] as well as by even larger population-based series (from 943 to 1919 patients) [8,19,20]. These data confirmed the orphan status of SCCP [21,22], and its pronounced tendency to harbor LNI [23], which is higher than prostate cancer, and comparable to bladder cancer.…”

Section: Discussionsupporting

confidence: 74%

“…Rates of inguinal lymph node invasion (LNI) in patients with squamous cell carcinoma of the penis (SCCP) increase with pT stage. These rates range from 11 to 18% in pT1b and are up to 20% in pT2-3 SCCP patients, or even higher [1][2][3][4]. There is no doubt about survival benefit of a therapeutic inguinal lymph node dissection (ILND) in SCCP patients when LNI is suspected or present [5].…”

Section: Introductionmentioning

confidence: 99%

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Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis

et al. 2022

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IntroductionThe survival benefit of inguinal lymph node dissection (ILND) vs no ILND in patients with squamous cell carcinoma of the penis (SCCP) and the absence of lymph node invasion is unclear. We addressed this uncertainty within the Surveillance, Epidemiology and End Results (SEER 2000(SEER -2018 database. Material and methodsWe identified lymph node negative SCCP patients who either underwent ILND (pN0) or clinical examination only (cN0). We tested for the effect of ILND vs no ILND on cancer-specific mortality (CSM) in Kaplan-Meier plots, univariable and multivariable Cox regression analyses, in a pT stage-specific fashion, before and after 1:3 propensity score matching (PSM). Sensitivity analyses were conducted according to historical and contemporary treatment periods as well as geographic regions. Results Of 2520 SCCP patients, 369 (15%) underwent ILND (pN0) vs 2151 (85%) did not (cN0). The pN0 vs cN0 distribution according to pT stages was as follows: 80 (7%) vs 1092 (93%) in pT1b, and 289 (21%) vs 1059 (79%) in pT2-3. At 36 months, CSM-free survival in pT2-3 stage was 89% in ILND vs 74% in no ILND patients (multivariable hazard ratio: 0.42, CI 0.30-0.60, p < 0.001). This result was confirmed in sensitivity analyses, and after 1:3 PSM. The same analyses could not be completed in pT1b stage due to insufficient number of observations and events. Conclusions In pT2-3 stage SCCP, a significantly lower CSM was recorded in lymph node negative patients treated with ILND than in their clinical lymph node negative counterparts who did not undergo ILND.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis

et al. 2022

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“…Palpable inguinal LNs are present in 28%–64% of the cases of penile cancer at the initial presentation. 2,8–10 Moreover, 47%–85% of the patients have a positive metastatic inguinal LN at diagnosis. 2,8–10 Managing regional LNs with inguinal lymphadenectomy is crucial for long-term patient survival.…”

Section: Discussionmentioning

confidence: 99%

“…2,8–10 Moreover, 47%–85% of the patients have a positive metastatic inguinal LN at diagnosis. 2,8–10 Managing regional LNs with inguinal lymphadenectomy is crucial for long-term patient survival. 1 In cN1/cN2 diseases, ILND is the standard procedure.…”

Section: Discussionmentioning

confidence: 99%

Detection of circulating tumor cells as therapeutic markers in patients with penile squamous cell carcinoma: A preliminary study

Kao

Yang

et al. 2022

Journal of the Chinese Medical Association

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Penile squamous cell carcinoma (PSCC) is a rare and aggressive tumor with a poor prognosis. Early identification followed by penectomy, possibly with pelvic lymph node (LN) dissection or systemic chemotherapy, has been proven to be the best strategy for the treatment of PSCC. 1 The mean 5-year survival rate is approximately 67% (https://www.cancer.org, American Cancer Society), although it drops to 12% in patients with metastatic disease. Among the patients with PSCC, 58% had inguinal masses and 40% had metastasis despite the small size (T2 and T1c) of the tumors. 2 Extended inguinal lymphadenectomy is the most widespread and useful approach for staging and treating inguinal metastasis in these cases. Although it is a commonly used technique, postoperative complications are often observed. 2 Since early and appropriate preoperative staging is crucial to the prognosis, identifying specific, sensitive, and noninvasive biomarkers is necessary to significantly improve the clinical treatment decision, survival rate, and quality of life in patients with PSCC.Circulating tumor cells (CTCs) are shed from primary or metastatic tumors. They subsequently travel through the circulation to distant organs and lead to the formation of distant secondary tumors. CTCs are responsible for the initiation of metastasis and hold important information for cancer prognosis and diagnosis. 3,4 The detection of CTCs in peripheral blood can represent a readily accessible "liquid biopsy" and is a reliable tool for disease progression monitoring and follow-up in several solid cancers. 3,[5][6][7] However, its application in patients with PSCC has not been analyzed to date.In the present study, we explored the presence of CTCs in the blood samples obtained from 14 patients with PSCC, 6 patients with balanoposthitis, and 6 healthy individuals using the IsoFlux (Fluxion Biosciences, Alameda, CA) platform to isolate the CTCs. Subsequently, immunofluorescence characterization was performed with the same markers used in the tumor tissue for PSCC diagnosis. IsoFlux utilizes immunomagnetic beads targeting antigens expressed on the cell surface, which allows the enrichment of the CTCs in the microfluidic device. We also evaluated the correlation between the number of CTCs detected in the samples and clinical parameters of PSCC.

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“…В среднем у 58 % больных (20-96 %) раком полового члена имеется местный инфекционный процесс: распад опухоли, наличие эрозий, изъязвлений опухолевого узла, воспалительные изменения регионарных лимфоузлов и т.д. [5][6][7][8][9][10]. Часто при распаде опухоли присоединяется вторичная инфекция, а при нахождении больного в стационаре возможно инфицирование нозокомиальными (госпитальными) патогенами, которые, как правило, резистентны к большинству антибиотиков [11][12][13].…”

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Antimicrobial Therapy During Cancer Treatment: A Case Report

et al. 2021

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Introduction. Penile cancer (pc) is a rare cancer. The standardized incidence rate of pc in russia is 0.82 cases per 100,000 males. On average, 58 % of patients (20–96 %) with pc have a local infection process: tumor decay, the presence of erosion, tumor ulceration, inflammatory changes in regional lymph nodes, etc. During hospitalization nosocomial pathogens may be possible causes of infection in ulcerative lesions.The aim of the study was to present the results of the treatment of tumor ulcer in a patient with penile cancer infected with multiresistant acinetobacter baumannii and klebsiella pneumoniae.Material and methods. We present a clinical observation of 54-year-old patient diagnosed with penile cancer pt4n3m0, with ulceration of the tumor, localized at the root of the penis and ulceration of metastatic lymph nodes in the left inguinal region and subsequent infection with highly resistant nosocomial microorganisms.Results. The patient received 6 courses of paclitaxel, ifosfamide and cisplatin with clinical effect, such as significant reduction of the tumor and therapeutic pathomorphosis of 3-rd degree. Then ileo-inguinal lymphadenectomy was performed on the left. A few months later the tumor continued to grow in the left groin area. During the 2nd line of chemotherapy (cisplatin, docetaxel and capecitabine), the patient had grade iii–iv neutropenia, febrile neutropenia. High fever and localized infection in the area of tumor ulceration with multiresistant hospital microorganisms was detected. Combined antibiotic therapy had temporary effect. After isolation of multiresistant carbapenemresistant k. Pneumoniae from the ulcer, the patient was prescribed ceftazidim/avibactam 2.5 g 3 times a day. Clinical effect, such as defervescence and significant reduction of the ulceration zone was seen subsequently.Conclusion. Etiotropic antibacterial therapy of the infected tumor ulcer resulted in a significant reduction in the manifestation of the infection process, allowing antitumor therapy to be continued, as well as surgery to be performed.

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Surgical Treatment of Invasive Squamous Cell Carcinoma of the Penis: Retrospective Analysis of 350 Cases

Cited by 276 publications

References 34 publications

Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis

Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis

Detection of circulating tumor cells as therapeutic markers in patients with penile squamous cell carcinoma: A preliminary study

Antimicrobial Therapy During Cancer Treatment: A Case Report

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