Surgical treatment of malignant tumors of the foot and ankle

Özger, Harzem; Eralp, Levent; Türker, Mehmet; Başaran, Mert

doi:10.1007/s10147-004-0470-9

Cited by 23 publications

(26 citation statements)

References 15 publications

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“…In both studies, the most frequent histologic type was synoviosarcoma. In relation to multimodality treatment, the review by Ozger et al (13) showed that 88% underwent limb salvage surgery, in most patients, the margins were wide, 81% received chemotherapy, and 69% received radiotherapy. In our study, more patients underwent amputation (44%), in most cases, wide or radical margins were obtained, and fewer patients received chemotherapy (62%) and radiotherapy (26%).…”

Section: Discussionmentioning

confidence: 99%

Tumors of the Foot and Ankle: A Single-institution Experience

Azevedo

Casanova

Guerra

et al. 2013

The Journal of Foot and Ankle Surgery

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Level of Clinical Evidence: 4Keywords: bone giant cell tumor neoplasm sarcoma soft tissue surgery a b s t r a c t Tumors of the foot and ankle are rare, and the particular clinicopathologic features, therapeutic approach, and outcomes in this setting are not well established. From January 2000 to December 2010, 72 patients with primary musculoskeletal tumors of the foot and ankle, both benign and malignant, were treated at a single institution. Of the 72 patients, 56% were female. The median age was 52 years. Of the 72 tumors, 62 (86.11%) were located in the foot and 10 were located in the ankle; 63 (87.5%) were soft tissue tumors and 9 (12.5%) were bone tumors. Overall, 56 (78%) were benign tumors and 16 (22%) were malignant tumors. The most frequent soft tissue and bone diagnosis was giant cell tumor. The median follow-up period was 49 months. The vast majority of the tumors were located in the foot. Benign tumors were dominant, outnumbering malignant tumors by more than 3 to 1. The diversity of the histologic benign types was evident, with giant cell tumor, angiomyoma, and lipoma the most frequent. Regarding the malignant tumors, a clear male predominance was present, the median age was 45 years, and the most frequent tumor was synoviosarcoma. The 9-year overall and disease-free survival rate was 65% and 40%, respectively.

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Section: Discussionmentioning

confidence: 99%

Tumors of the Foot and Ankle: A Single-institution Experience

Azevedo

Casanova

Guerra

et al. 2013

The Journal of Foot and Ankle Surgery

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“…1,6,7,14,15,19,20 Additionally, few reports did not describe the oncologic outcomes of STS of the foot. 6 So, it is difficult to compare the studies and describe the prognostic factors and to get optimal therapeutic approach.…”

Section: Discussionmentioning

confidence: 99%

“…Limb salvage surgery with pre or postoperative radiotherapy was performed to 6 patients and distant metastasis was detected in one patient after a mean 74.2 months of follow-up. 15 The studies that evaluated the long-term outcomes of patients treated with limb sparing surgery and radiotherapy for STS of the foot demonstrated an excellent rates of local control and survival with good functional outcome (Table 4). [16][17][18] However, in Jyothirmayi et al's series local relapse-free survival was high as 44%, compared to other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Synovial sarcomas were reported to be the most frequent malignant histological type among the STS of the foot. 6,7,9,15,20,[23][24][25][26] Synovial sarcoma has poor prognosis due to the patterns of recurrence such as local invasion potential along the fascia, regional lymph node metastases and the distant metastases. 22 In this study, even though there is a distinct difference of local control, disease-free and overall survival rates between patients with synovial histopathology and the patients with other histopathology, this difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Limb preservation management with combined surgery and radiotherapy is an alternative treatment approach to amputation. [12][13][14][15] There has been few series focused on STS of the foot and evaluated the results of limb preservation surgery with radiotherapy. 10,12,[16][17][18] The objective of the present study was to review the long term follow up results of primary STS of the foot who underwent limb sparing surgery and preoperative or postoperative radiotherapy in our institute.…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Outcome of Soft Tissue Sarcomas of the Foot Treated with Limb Salvage Surgery and Radiotherapy.

Öksüz¹

2016

UHOD

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The objective of the present study was to review the long term follow up results of patients with primary soft tissue sarcomas (STS) of the foot who underwent limb sparing surgery with pre-or postoperative radiotherapy. Eleven patients with primary STS of the foot treated with limb sparing surgery and radiotherapy between 1980 and 2008 were retrospectively analyzed. The median tumor size was 5.5 cm (2-8 cm). All patients were treated with limb sparing surgery. Surgical margin was positive in 5 patients. The most frequent histopathological diagnosis was synovial sarcoma (73%). Radiotherapy was performed postoperatively to 8 patients and preoperatively to 3 patients. Six cases with high grade and large tumor received chemotherapy. The median follow-up period was 73 months (11 to 224 months). The 5-year overall survival was 78.8%. Three patients developed local recurrence at median of 12 months (6-13 months). The histopathology of these patients was synovial sarcoma. The surgical margins were positive in one of them. One of the recurrent patients was salvaged by further limb sparing surgery and 2 patients required amputation. These 3 cases developed lung metastasis and 2 of them died due to metastatic disease. Eight patients without local recurrence remained disease-free at a median follow up of 73 months. Multidisciplinary approach is essential as in the other localizations, to get good oncologic and functional treatment outcomes in primary soft tissue sarcomas of the foot. Radiotherapy enables the limb preservation with good local control rate. Keywords: Soft tissue sarcoma, Foot, Radiotherapy ÖZET Ekstremite Koruyucu Cerrahi ve Radyoterapi Uygulanan Ayak Yerleşimli Yumuşak Doku Sarkomlarında Uzun Dönem Takip SouçlarıBu çalışmanın amacı; primer ayak yerleşimli yumuşak doku sarkomu tanısıyla ekstremite koruyucu cerrahi ve preoperatif veya postoperatif radyoterapi uygulanan hastalarda uzun dönem takip sonuçlarının değerlendirilmesidir. 1980-2008 yılları arasında, ekstremite koruyucu cerrahi ve radyoterapi uygulanan primer ayak yerleşimli yumuşak doku sarkomlu 11 olgu retrospektif olarak değerlendirildi. Tümör boyutu medyan 5.5 cm'dir (2-8 cm). Tüm olgulara ekstremite koruyucu cerrahi yapıldı. Beş olguda cerrahi sınır pozitif saptandı. En sık görülen histolojik grup sinovyal sarkom'dur (73%). Sekiz olguya postoperatif radyoterapi, 3 olguya preoperatif radyoterapi uygulandı. Yüksek grad ve büyük tümörü olan 6 olguya kemoterapi verildi. Medyan takip süresi 73 ay'dır (11-224 ay). 5 yıllık genel sağkalım %78.8'dir. Üç olguda medyan 12 ayda (6-13 ay) lokal nüks gelişti. Nüks gelişen tüm olguların histopatolojisi sinovyal sarkomdu ve sadece bir olguda cerrahi sınır pozitifti. İki olguya nüks nedeniyle amputasyon yapılırken, diğer olguya tekrar ekstremite koruyucu cerrahi yapıldı. Lokal nüks gelişen bu üç olguda akciğer metastazı gelişti ve 2'si hastalıktan dolayı kaybedildi. Lokal nüksü olmayan 8 olgu medyan 73 ay takip süresi içerisinde hastalıksız olarak takip edilmektedir. Primer ayak yumuşak doku sarkomlarında...

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Cytomorphological spectrum of hand, wrist, and foot lesions at tertiary care center in central India

Panwar

Tandon

Joshi

et al. 2020

Diagnostic Cytopathology

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Background: Fine-needle aspiration cytology (FNAC) being a fast technique is used as a primary investigation to diagnose wide spectrum of hand, wrist, and foot lesions. These sites are prone to trauma, reparative, and infectious process, which forms mass lesions mimicking neoplasia. Our study highlighted the importance of FNAC with the chance of reduction in biopsy or excision. Aims and objectives: To report the prevalence and cytomorphological spectrum of hand and foot lesions with the aim of consolidating the diagnostic potential and also correlate the cytological evaluation with histopathology. Materials and methods: This retrospective observational study was done in central India for the period of 5.5 years. The archive cytology slides of patients with palpable lesions at these sites are reviewed and analyzed. Results: Of the total 6512 FNAC cases, 115 cases presented as swelling in the hand, wrist, and foot are reviewed. Age ranged from 4 months to 80 years with M: F = 1.25:1. Of the 111 satisfactory smears (96.7%), 21 cases (18.9%) diagnosed as inflammatory lesion, including synovitis, tuberculosis, gout, and fat necrosis. Sixty cases as benign non-neoplastic (tumor-like) lesions with the most common being ganglion (29). Of the 30 neoplastic lesions, 26 were benign tumor with the most common being mesenchymal neoplasms (19), followed by giant cell tumor of tendon sheath. Malignant tumors included malignant melanoma, small round cell tumor, and squamous-cell carcinoma. Conclusion: FNAC is useful investigation for early diagnosis of hand and foot lesions. These lesions are benign mostly with less malignancy occurrence (<2%), compared with other soft tissue lesions.

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Surgical treatment of malignant tumors of the foot and ankle

Cited by 23 publications

References 15 publications

Tumors of the Foot and Ankle: A Single-institution Experience

Tumors of the Foot and Ankle: A Single-institution Experience

Long-Term Outcome of Soft Tissue Sarcomas of the Foot Treated with Limb Salvage Surgery and Radiotherapy.

Cytomorphological spectrum of hand, wrist, and foot lesions at tertiary care center in central India

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