Surgical treatment of mediastinal tumors

Wychulis, Adam R.; Payne, W. Spencer; Clagett, O. Theron; Woolner, Lewis B.

doi:10.1016/s0022-5223(19)42048-5

Cited by 362 publications

(83 citation statements)

References 15 publications

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“…The anatomical locations of tumors previously reported [4,8,[15][16][17][18] were similar to our series. The reported range for anterior lesions was 49-59%, for middle mediastinal masses 18-25%, and for posterior mediastinal tumors 23-27% [15].…”

Section: Discussionsupporting

confidence: 91%

“…Thus comparison between adult and pediatric populations should reflect the differences in clinical characteristics. The distribution of tumor histology in the pediatric populations was different from that of adult populations, which also differed in some respects from the some previous reports on North American populations [1][2][3][4][8][9][10][11]. In pediatric populations, neurogenic tumors are the most common, comprising 58% [2], 36% [3], 35% [4], 43% [9], 44% [11], and 34% [1], respectively.…”

Section: Discussioncontrasting

confidence: 57%

See 1 more Smart Citation

Clinical spectrum of primary mediastinal tumors: A comparison of adult and pediatric populations at a single Japanese institution

Takeda

Miyoshi

Akashi

et al. 2003

Journal of Surgical Oncology

120

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 57%

Clinical spectrum of primary mediastinal tumors: A comparison of adult and pediatric populations at a single Japanese institution

Takeda

Miyoshi

Akashi

et al. 2003

Journal of Surgical Oncology

120

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“…17,20 Overall, GCTs account for 1-20% of mediastinal cysts and tumours. 16,[21][22][23][24][25] In the paediatric age group the mediastinum is the second most common site for extragonadal GCTs (type I tumours), with the sacrococcygeal region being the most common site with up 45% of cases reported here. Approximately 7% of cases of paediatric GCTs arise in the mediastinum.…”

Section: Tumour Types Germ Cell Tumoursmentioning

confidence: 99%

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Bakker

Oosterhuis

2009

Histopathology

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Masses within the thymus and mediastinum are frequently biopsied to establish a diagnosis. The specimens sent for histopathological analysis are typically small (needle) biopsy specimens on which the pathologist is challenged to provide a classifying diagnosis. Despite the fact that the pathology of the anterior mediastinum is predominantly centred on the thymus and it thus might be expected that the range of possible diagnoses is limited, the list of disease entities is in fact extensive, encompassing hyperplastic conditions and both benign and malignant neoplasms. In addition to primary thymic epithelial tumours, a number of less common diseases typical for this location may be encountered, including extragonadal germ cell tumours, lymphomas, soft tissue tumours and a number of conditions which may simulate a tumour, such as cysts and inflammatory conditions. In this review, the disease entities that may be encountered in biopsy material from anterior mediastinal/thymic processes are discussed and an approach to tackle the differential diagnosis is provided.

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“…Some retrospective reviews have suggested that surgical resection or debulking should be performed where possible. 9,14,16,17,45,46 Although Schantz et al recommended surgery in all cases, they found no recurrences in 11 patients treated with primary RT. 16 Selection bias distorts the findings because small tumours are resected whereas bulkier, less biologically favourable masses are referred for radiation.…”

Section: Seminomamentioning

confidence: 97%

“…It is a relatively rare cause of mediastinal enlargement. 9 In a study by Luna and Valenzuela-Tamariz of 1687 mediastinal tumours examined at postmortem, only 19 (1.1%) were of germ cell origin. 10 In our cases, primary germ cell tumours in the mediastinum invariably occupied the anterior compartment.…”

mentioning

confidence: 97%

Primary malignant mediastinal germ cell tumours: A literature review and a study of 18 cases

Kiffer

Sandeman

1999

Australasian Radiology

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From 1957 to 1992, 18 cases of primary mediastinal germ cell tumours were referred to the Peter MacCallum Cancer Institute (PMCI). Six were seminomas, six were mixed germ cell tumours, two were embryonal cell carcinomas, three were teratocarcinomas and one was labelled an 'anaplastic germ cell tumour'. Two of the 18 patients were female. For seminomas, surgical (and in one case chemotherapeutic) debulking, followed by radiotherapy produced the best results. Mediastinal doses ranged from 30 to 40 Gy. Local control was achieved in those patients receiving mediastinal radiotherapy. Four patients currently survive disease-free. The non-seminomatous germ cell tumours showed a significantly poorer survival, and only two of 12 patients remain alive in remission at 110 and 130 months after diagnosis. Survival has been updated as of November 1997. Attention is focused on the anterior position of the primary germ cell tumours in the mediastinum. A review of the literature up to and including 1997 is presented.

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Surgical treatment of mediastinal tumors

Cited by 362 publications

References 15 publications

Clinical spectrum of primary mediastinal tumors: A comparison of adult and pediatric populations at a single Japanese institution

Clinical spectrum of primary mediastinal tumors: A comparison of adult and pediatric populations at a single Japanese institution

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Primary malignant mediastinal germ cell tumours: A literature review and a study of 18 cases

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